Delta-like 1

Delta-like 1
Delta-like 1 (Drosophila)
Identifiers
Symbols DLL1; DELTA1; DL1; Delta
External IDs OMIM606582 MGI104659 HomoloGene4104 GeneCards: DLL1 Gene
RNA expression pattern
PBB GE DLL1 gnf1h00074 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 28514 13388
Ensembl ENSG00000198719 ENSMUSG00000014773
UniProt O00548 Q6PFV7
RefSeq (mRNA) NM_005618 NM_007865.3
RefSeq (protein) NP_005609 NP_031891.2
Location (UCSC) Chr 6:
170.59 – 170.6 Mb
Chr 17:
15.5 – 15.51 Mb
PubMed search [1] [2]

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.[1]

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.[1]

Interactions

Delta-like 1 has been shown to interact with NOTCH2.[2][3][4]

References

  1. ^ a b "Entrez Gene: DLL1 delta-like 1 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28514. 
  2. ^ Shimizu, K; Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (Jul. 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. (United States) 276 (28): 25753–8. doi:10.1074/jbc.M103473200. ISSN 0021-9258. PMID 11346656. 
  3. ^ Blaumueller, C M; Qi H, Zagouras P, Artavanis-Tsakonas S (Jul. 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell (UNITED STATES) 90 (2): 281–91. doi:10.1016/S0092-8674(00)80336-0. ISSN 0092-8674. PMID 9244302. 
  4. ^ Shimizu, K; Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (Sep. 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. ISSN 0270-7306. PMC 88767. PMID 10958687. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=88767. 

Further reading




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