Delta-like 1

Delta-like 1 (Drosophila)
Identifiers
Symbols	DLL1; DELTA1; DL1; Delta
External IDs	OMIM: 606582 MGI: 104659 HomoloGene: 4104 GeneCards: DLL1 Gene
Gene Ontology Molecular function • Notch binding • calcium ion binding • protein binding Cellular component • extracellular region • plasma membrane • integral to plasma membrane • cytoplasmic vesicle Biological process • cell fate determination • somite specification • cell communication • Notch signaling pathway • Notch signaling pathway • Notch receptor processing • multicellular organismal development • determination of left/right symmetry • compartment pattern formation • hemopoiesis • cell differentiation • regulation of cell adhesion • negative regulation of cell differentiation • negative regulation of auditory receptor cell differentiation • inner ear development Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	28514	13388
Ensembl	ENSG00000198719	ENSMUSG00000014773
UniProt	O00548	Q6PFV7
RefSeq (mRNA)	NM_005618	NM_007865.3
RefSeq (protein)	NP_005609	NP_031891.2
Location (UCSC)	Chr 6: 170.59 – 170.6 Mb	Chr 17: 15.5 – 15.51 Mb
PubMed search	[1]	[2]

Delta-like protein 1 is a protein that in humans is encoded by the DLL1 gene.^[1]

DLL1 is a human homolog of the Notch Delta ligand and is a member of the delta/serrate/jagged family. It plays a role in mediating cell fate decisions during hematopoiesis. It may play a role in cell-to-cell communication.^[1]

Interactions

Delta-like 1 has been shown to interact with NOTCH2.^[2][3][4]

References

1. ^ ^{a b} "Entrez Gene: DLL1 delta-like 1 (Drosophila)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=28514. 
2. ^ Shimizu, K; Chiba S, Saito T, Kumano K, Takahashi T, Hirai H (Jul. 2001). "Manic fringe and lunatic fringe modify different sites of the Notch2 extracellular region, resulting in different signaling modulation". J. Biol. Chem. (United States) 276 (28): 25753–8. doi:10.1074/jbc.M103473200. ISSN 0021-9258. PMID 11346656. 
3. ^ Blaumueller, C M; Qi H, Zagouras P, Artavanis-Tsakonas S (Jul. 1997). "Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane". Cell (UNITED STATES) 90 (2): 281–91. doi:10.1016/S0092-8674(00)80336-0. ISSN 0092-8674. PMID 9244302. 
4. ^ Shimizu, K; Chiba S, Hosoya N, Kumano K, Saito T, Kurokawa M, Kanda Y, Hamada Y, Hirai H (Sep. 2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. (UNITED STATES) 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. ISSN 0270-7306. PMC 88767. PMID 10958687. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=88767. 

Further reading

• Watt FM (2002). "The stem cell compartment in human interfollicular epidermis". J. Dermatol. Sci. 28 (3): 173–80. doi:10.1016/S0923-1811(02)00003-8. PMID 11912004. 
• Lewis AK, Frantz GD, Carpenter DA et al. (1999). "Distinct expression patterns of notch family receptors and ligands during development of the mammalian inner ear". Mech. Dev. 78 (1–2): 159–63. doi:10.1016/S0925-4773(98)00165-8. PMID 9858718. 
• Mitsiadis TA, Hirsinger E, Lendahl U, Goridis C (1999). "Delta-notch signaling in odontogenesis: correlation with cytodifferentiation and evidence for feedback regulation". Dev. Biol. 204 (2): 420–31. doi:10.1006/dbio.1998.9092. PMID 9882480. 
• Gray GE, Mann RS, Mitsiadis E et al. (1999). "Human Ligands of the Notch Receptor". Am. J. Pathol. 154 (3): 785–94. doi:10.1016/S0002-9440(10)65325-4. PMC 1866435. PMID 10079256. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1866435. 
• Beckers J, Clark A, Wünsch K et al. (1999). "Expression of the mouse Delta1 gene during organogenesis and fetal development". Mech. Dev. 84 (1–2): 165–8. doi:10.1016/S0925-4773(99)00065-9. PMID 10473134. 
• Morrison A, Hodgetts C, Gossler A et al. (1999). "Expression of Delta1 and Serrate1 (Jagged1) in the mouse inner ear". Mech. Dev. 84 (1–2): 169–72. doi:10.1016/S0925-4773(99)00066-0. PMID 10473135. 
• Han W, Ye Q, Moore MA (2000). "A soluble form of human Delta-like-1 inhibits differentiation of hematopoietic progenitor cells". Blood 95 (5): 1616–25. PMID 10688816. 
• Shimizu K, Chiba S, Hosoya N et al. (2000). "Binding of Delta1, Jagged1, and Jagged2 to Notch2 Rapidly Induces Cleavage, Nuclear Translocation, and Hyperphosphorylation of Notch2". Mol. Cell. Biol. 20 (18): 6913–22. doi:10.1128/MCB.20.18.6913-6922.2000. PMC 88767. PMID 10958687. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=88767. 
• Shimizu K, Chiba S, Saito T et al. (2000). "Physical interaction of Delta1, Jagged1, and Jagged2 with Notch1 and Notch3 receptors". Biochem. Biophys. Res. Commun. 276 (1): 385–9. doi:10.1006/bbrc.2000.3469. PMID 11006133. 
• Jaleco AC, Neves H, Hooijberg E et al. (2001). "Differential Effects of Notch Ligands Delta-1 and Jagged-1 in Human Lymphoid Differentiation". J. Exp. Med. 194 (7): 991–1002. doi:10.1084/jem.194.7.991. PMC 2193482. PMID 11581320. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2193482. 
• Shimizu K, Chiba S, Saito T et al. (2002). "Integrity of intracellular domain of Notch ligand is indispensable for cleavage required for release of the Notch2 intracellular domain". EMBO J. 21 (3): 294–302. doi:10.1093/emboj/21.3.294. PMC 125840. PMID 11823422. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=125840. 
• Panin VM, Shao L, Lei L et al. (2002). "Notch ligands are substrates for protein O-fucosyltransferase-1 and Fringe". J. Biol. Chem. 277 (33): 29945–52. doi:10.1074/jbc.M204445200. PMID 12036964. 
• Sakamoto K, Yamaguchi S, Ando R et al. (2002). "The nephroblastoma overexpressed gene (NOV/ccn3) protein associates with Notch1 extracellular domain and inhibits myoblast differentiation via Notch signaling pathway". J. Biol. Chem. 277 (33): 29399–405. doi:10.1074/jbc.M203727200. PMID 12050162. 
• Ohishi K, Varnum-Finney B, Bernstein ID (2002). "Delta-1 enhances marrow and thymus repopulating ability of human CD34+CD38– cord blood cells". J. Clin. Invest. 110 (8): 1165–74. doi:10.1172/JCI16167. PMC 150801. PMID 12393852. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=150801. 
• Karlström H, Beatus P, Dannaeus K et al. (2003). "A CADASIL-mutated Notch 3 receptor exhibits impaired intracellular trafficking and maturation but normal ligand-induced signaling". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 17119–24. doi:10.1073/pnas.252624099. PMC 139279. PMID 12482954. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139279. 
• Tohda S, Murata-Ohsawa M, Sakano S, Nara N (2003). "Notch ligands, Delta-1 and Delta-4 suppress the self-renewal capacity and long-term growth of two myeloblastic leukemia cell lines". Int. J. Oncol. 22 (5): 1073–9. PMID 12684674. 
• Six E, Ndiaye D, Laabi Y et al. (2003). "The Notch ligand Delta1 is sequentially cleaved by an ADAM protease and γ-secretase". Proc. Natl. Acad. Sci. U.S.A. 100 (13): 7638–43. doi:10.1073/pnas.1230693100. PMC 164639. PMID 12794186. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164639. 
• LaVoie MJ, Selkoe DJ (2003). "The Notch ligands, Jagged and Delta, are sequentially processed by alpha-secretase and presenilin/gamma-secretase and release signaling fragments". J. Biol. Chem. 278 (36): 34427–37. doi:10.1074/jbc.M302659200. PMID 12826675. 
• Clark HF, Gurney AL, Abaya E et al. (2003). "The Secreted Protein Discovery Initiative (SPDI), a Large-Scale Effort to Identify Novel Human Secreted and Transmembrane Proteins: A Bioinformatics Assessment". Genome Res. 13 (10): 2265–70. doi:10.1101/gr.1293003. PMC 403697. PMID 12975309. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=403697.