Natriuretic peptide precursor C

Natriuretic peptide precursor C
Natriuretic peptide C
Symbols NPPC; CNP
External IDs OMIM600296 MGI97369 HomoloGene7867 GeneCards: NPPC Gene
RNA expression pattern
PBB GE NPPC 221348 at tn.png
More reference expression data
Species Human Mouse
Entrez 4880 18159
Ensembl ENSG00000163273 ENSMUSG00000026241
UniProt P23582 Q544K5
RefSeq (mRNA) NM_024409 NM_010933.5
RefSeq (protein) NP_077720 NP_035063.1
Location (UCSC) Chr 2:
232.79 – 232.79 Mb
Chr 1:
88.56 – 88.57 Mb
PubMed search [1] [2]

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene.[1][2][3] The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).



Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide, CNP, encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.[1] Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for NPRA.[4]


  1. ^ a b "Entrez Gene: NPPC natriuretic peptide precursor C". 
  2. ^ Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Res. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189. 
  3. ^ Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765. 
  4. ^ Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763. 

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