Natriuretic peptide precursor C

Natriuretic peptide precursor C
Natriuretic peptide C
Identifiers
Symbols NPPC; CNP
External IDs OMIM600296 MGI97369 HomoloGene7867 GeneCards: NPPC Gene
RNA expression pattern
PBB GE NPPC 221348 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 4880 18159
Ensembl ENSG00000163273 ENSMUSG00000026241
UniProt P23582 Q544K5
RefSeq (mRNA) NM_024409 NM_010933.5
RefSeq (protein) NP_077720 NP_035063.1
Location (UCSC) Chr 2:
232.79 – 232.79 Mb
Chr 1:
88.56 – 88.57 Mb
PubMed search [1] [2]

Natriuretic peptide precursor C, also known as NPPC, is a protein that in humans is encoded by the NPPC gene.[1][2][3] The precursor NPPC protein is cleaved to the 22 amino acid peptide C-type natriuretic peptide (CNP).

Contents

Function

Natriuretic peptides comprise a family of 3 structurally related molecules: atrial natriuretic peptide (ANP), brain natriuretic peptide (BNP), and C-type natriuretic peptide, CNP, encoded by a gene symbolized NPPC. These peptides possess potent natriuretic, diuretic, and vasodilating activities and are implicated in body fluid homeostasis and blood pressure control.[1] Unlike ANP and BNP, CNP does not have direct natriuretic activity. This is because CNP is a selective agonist for the B-type natriuretic receptor (NPRB) whereas ANP and BNP are selective for NPRA.[4]

References

  1. ^ a b "Entrez Gene: NPPC natriuretic peptide precursor C". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4880. 
  2. ^ Kaneko T, Shirakami G, Nakao K, Nagata I, Nakagawa O, Hama N, Suga S, Miyamoto S, Kubo H, Hirai O (May 1993). "C-type natriuretic peptide (CNP) is the major natriuretic peptide in human cerebrospinal fluid". Brain Res. 612 (1–2): 104–9. doi:10.1016/0006-8993(93)91649-D. PMID 8330189. 
  3. ^ Ogawa Y, Itoh H, Yoshitake Y, Inoue M, Yoshimasa T, Serikawa T, Nakao K (November 1994). "Molecular cloning and chromosomal assignment of the mouse C-type natriuretic peptide (CNP) gene (Nppc): comparison with the human CNP gene (NPPC)". Genomics 24 (2): 383–7. doi:10.1006/geno.1994.1633. PMID 7698765. 
  4. ^ Barr CS, Rhodes P, Struthers AD (1996). "C-type natriuretic peptide". Peptides 17 (7): 1243–51. doi:10.1016/S0196-9781(96)00110-6. PMID 8959763. 

Further reading

External links


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