MHC class I polypeptide-related sequence A

MHC class I polypeptide-related sequence A
PDB rendering based on 1b3j.
Available structures PDB 1B3J, 1HYR
Identifiers
Symbols	MICA; FLJ36918; FLJ60820; MGC111087; MGC21250; MIC-A; PERB11.1
External IDs	OMIM: 600169 MGI: 2179989 HomoloGene: 125585 GeneCards: MICA Gene
Gene Ontology Molecular function • beta-2-microglobulin binding • natural killer cell lectin-like receptor binding Cellular component • extracellular space • cytoplasm • plasma membrane • integral to plasma membrane • cell surface • MHC class I protein complex Biological process • stimulatory C-type lectin receptor signaling pathway • immune response to tumor cell • response to DNA damage stimulus • response to heat • cytolysis • antigen processing and presentation • defense response to bacterium • gamma-delta T cell activation • defense response to virus Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	100507436	243864
Ensembl	ENSG00000183214	n/a
UniProt	Q29983	n/a
RefSeq (mRNA)	NM_000247.1	XM_985890
RefSeq (protein)	NP_000238.1	XP_990984
Location (UCSC)	Chr c6_QBL: 31.5 – 31.52 Mb	n/a
PubMed search	[1]	[2]

MHC class I polypeptide-related sequence A is a protein that in humans is encoded by the MICA gene.^[1]

MICA encodes the highly polymorphic MHC (HLA) class I chain-related gene A. The protein product is expressed on the cell surface, although unlike canonical class I molecules does not seem to associate with beta-2-microglobulin. It is thought that MICA functions as a stress-induced antigen that is broadly recognized by NK cells, NKT cells, and most of the subtypes of T cells.^[2]

See also

• MHC class I
• Major histocompatibility complex

References

1. ^ Bahram S, Bresnahan M, Geraghty DE, Spies T (Aug 1994). "A second lineage of mammalian major histocompatibility complex class I genes". Proc Natl Acad Sci U S A 91 (14): 6259–63. doi:10.1073/pnas.91.14.6259. PMC 44180. PMID 8022771. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=44180. 
2. ^ "Entrez Gene: MICA MHC class I polypeptide-related sequence A". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4276. 

Further reading

• Klein J, O'hUigin C (1994). "The conundrum of nonclassical major histocompatibility complex genes". Proc. Natl. Acad. Sci. U.S.A. 91 (14): 6251–2. doi:10.1073/pnas.91.14.6251. PMC 44177. PMID 8022769. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=44177. 
• Bahram S, Spies T (1997). "The MIC gene family". Res. Immunol. 147 (5): 328–33. doi:10.1016/0923-2494(96)89646-5. PMID 8876061. 
• Blumberg RS (1998). "Current concepts in mucosal immunity. II. One size fits all: nonclassical MHC molecules fulfill multiple roles in epithelial cell function". Am. J. Physiol. 274 (2 Pt 1): G227–31. PMID 9486173. 

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