MICB

MHC class I polypeptide-related sequence B, also known as MICB, is a human gene.

PBB_Summary
section_title =
summary_text = This gene encodes a heavily glycosylated protein which is a ligand for the NKG2D type II receptor. Binding of the ligand activates the cytolytic response of natural killer (NK) cells, CD8 alphabeta T cells, and gammadelta T cells which express the receptor. This protein is stress-induced and is similar to MHC class I molecules; however, it does not associate with beta-2-microglobulin or bind peptides.cite web | title = Entrez Gene: MICB MHC class I polypeptide-related sequence B| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=4277| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Braud VM, Allan DS, McMichael AJ |title=Functions of nonclassical MHC and non-MHC-encoded class I molecules. |journal=Curr. Opin. Immunol. |volume=11 |issue= 1 |pages= 100–8 |year= 1999 |pmid= 10047540 |doi=
*cite journal | author=Borrego F, Kabat J, Kim DK, "et al." |title=Structure and function of major histocompatibility complex (MHC) class I specific receptors expressed on human natural killer (NK) cells. |journal=Mol. Immunol. |volume=38 |issue= 9 |pages= 637–60 |year= 2002 |pmid= 11858820 |doi=
*cite journal | author=Leelayuwat C, Townend DC, Degli-Esposti MA, "et al." |title=A new polymorphic and multicopy MHC gene family related to nonmammalian class I. |journal=Immunogenetics |volume=40 |issue= 5 |pages= 339–51 |year= 1994 |pmid= 7927538 |doi=
*cite journal | author=Bahram S, Bresnahan M, Geraghty DE, Spies T |title=A second lineage of mammalian major histocompatibility complex class I genes. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6259–63 |year= 1994 |pmid= 8022771 |doi=
*cite journal | author=Bahram S, Spies T |title=Nucleotide sequence of a human MHC class I MICB cDNA. |journal=Immunogenetics |volume=43 |issue= 4 |pages= 230–3 |year= 1996 |pmid= 8575823 |doi=
*cite journal | author=Nalabolu SR, Shukla H, Nallur G, "et al." |title=Genes in a 220-kb region spanning the TNF cluster in human MHC. |journal=Genomics |volume=31 |issue= 2 |pages= 215–22 |year= 1997 |pmid= 8824804 |doi= 10.1006/geno.1996.0034
*cite journal | author=Bonaldo MF, Lennon G, Soares MB |title=Normalization and subtraction: two approaches to facilitate gene discovery. |journal=Genome Res. |volume=6 |issue= 9 |pages= 791–806 |year= 1997 |pmid= 8889548 |doi=
*cite journal | author=Groh V, Bahram S, Bauer S, "et al." |title=Cell stress-regulated human major histocompatibility complex class I gene expressed in gastrointestinal epithelium. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=93 |issue= 22 |pages= 12445–50 |year= 1996 |pmid= 8901601 |doi=
*cite journal | author=Bahram S, Shiina T, Oka A, "et al." |title=Genomic structure of the human MHC class I MICB gene. |journal=Immunogenetics |volume=45 |issue= 2 |pages= 161–2 |year= 1997 |pmid= 8952966 |doi=
*cite journal | author=Gaudieri S, Leelayuwat C, Townend DC, "et al." |title=Allelic and interlocus comparison of the PERB11 multigene family in the MHC. |journal=Immunogenetics |volume=45 |issue= 3 |pages= 209–16 |year= 1997 |pmid= 8995188 |doi=
*cite journal | author=Pellet P, Renaud M, Fodil N, "et al." |title=Allelic repertoire of the human MICB gene. |journal=Immunogenetics |volume=46 |issue= 5 |pages= 434–6 |year= 1997 |pmid= 9271635 |doi=
*cite journal | author=Ando H, Mizuki N, Ota M, "et al." |title=Allelic variants of the human MHC class I chain-related B gene (MICB). |journal=Immunogenetics |volume=46 |issue= 6 |pages= 499–508 |year= 1997 |pmid= 9321430 |doi=
*cite journal | author=Groh V, Steinle A, Bauer S, Spies T |title=Recognition of stress-induced MHC molecules by intestinal epithelial gammadelta T cells. |journal=Science |volume=279 |issue= 5357 |pages= 1737–40 |year= 1998 |pmid= 9497295 |doi=
*cite journal | author=Visser CJ, Tilanus MG, Schaeffer V, "et al." |title=Sequencing-based typing reveals six novel MHC class I chain-related gene B (MICB) alleles. |journal=Tissue Antigens |volume=51 |issue= 6 |pages= 649–52 |year= 1998 |pmid= 9694358 |doi=
*cite journal | author=Steinle A, Groh V, Spies T |title=Diversification, expression, and gamma delta T cell recognition of evolutionarily distant members of the MIC family of major histocompatibility complex class I-related molecules. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=95 |issue= 21 |pages= 12510–5 |year= 1998 |pmid= 9770516 |doi=
*cite journal | author=Groh V, Rhinehart R, Secrist H, "et al." |title=Broad tumor-associated expression and recognition by tumor-derived gamma delta T cells of MICA and MICB. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 12 |pages= 6879–84 |year= 1999 |pmid= 10359807 |doi=
*cite journal | author=Tay GK, Hui J, Gaudieri S, "et al." |title=PERB11 (MIC): a polymorphic MHC gene is expressed in skin and single nucleotide polymorphisms are associated with psoriasis. |journal=Clin. Exp. Immunol. |volume=119 |issue= 3 |pages= 553–8 |year= 2000 |pmid= 10691930 |doi=
*cite journal | author=Fischer G, Pérez-Rodríguez M, Argüello JR, "et al." |title=Three novel MICB alleles. |journal=Tissue Antigens |volume=55 |issue= 2 |pages= 166–70 |year= 2000 |pmid= 10746790 |doi=
*cite journal | author=Cerwenka A, Bakker AB, McClanahan T, "et al." |title=Retinoic acid early inducible genes define a ligand family for the activating NKG2D receptor in mice. |journal=Immunity |volume=12 |issue= 6 |pages= 721–7 |year= 2000 |pmid= 10894171 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes