CoA-disulfide reductase

CoA-disulfide reductase
Identifiers
EC number	1.8.1.14
CAS number	206770-55-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a CoA-disulfide reductase (EC 1.8.1.14) is an enzyme that catalyzes the chemical reaction

2 CoA + NAD(P)+ $\rightleftharpoons$ CoA-disulfide + NAD(P)H + H⁺

The 3 substrates of this enzyme are CoA, NAD⁺, and NADP⁺, whereas its 4 products are CoA-disulfide, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on a sulfur group of donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is CoA:NAD(P)+ oxidoreductase. Other names in common use include CoA-disulfide reductase (NADH2), NADH2:CoA-disulfide oxidoreductase, CoA:NAD+ oxidoreductase, CoADR, and coenzyme A disulfide reductase.

References

• Setlow B, Setlow P (1977). "Levels of acetyl coenzyme A, reduced and oxidized coenzyme A, and coenzyme A in disulfide linkage to protein in dormant and germinated spores and growing and sporulating cells of Bacillus megaterium". J. Bacteriol. 132 (2): 444–52. PMC 221883. PMID 410791. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=221883. 
• delCardayre SB, Stock KP, Newton GL, Fahey RC, Davies JE (1998). "Coenzyme A disulfide reductase, the primary low molecular weight disulfide reductase from Staphylococcus aureus. Purification and characterization of the native enzyme". J. Biol. Chem. 273 (10): 5744–51. doi:10.1074/jbc.273.10.5744. PMID 9488707. 
• Luba J, Charrier V, Claiborne A (1999). "Coenzyme A-disulfide reductase from Staphylococcus aureus: evidence for asymmetric behavior on interaction with pyridine nucleotides". Biochemistry. 38 (9): 2725–37. doi:10.1021/bi9825899. PMID 10052943. 
• Crane EJ 3rd; Ward, DE; Feasel, JM; Lancaster, KM; Murphy, RD; Mallet, TC; Crane Ej, 3rd (2005). "Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii. Implications for this disulfide metabolism of anaerobic hyperthermophiles". Febs. J. 272 (5): 1189–200. doi:10.1111/j.1742-4658.2005.04555.x. PMID 15720393. 

This EC 1.8 enzyme-related article is a stub. You can help Wikipedia by expanding it.v · Categories: Oxidoreductase stubs EC 1.8.1 NADPH-dependent enzymes NADH-dependent enzymes Enzymes of unknown structure Wikimedia Foundation. 2010. Игры ⚽ Нужно решить контрольную? Bis-gamma-glutamylcystine reductase Forked Run State Park Look at other dictionaries: CoA-glutathione reductase — Identifiers EC number 1.8.1.10 CAS number 37256 33 0 …   Wikipedia List of EC numbers (EC 1) — This list contains a list of EC numbers for the first group, EC 1, oxidoreducatases, placed in numerical order as determined by the Nomenclature Committee of the International Union of Biochemistry and Molecular Biology.EC 1.1 Acting on the CH OH …   Wikipedia Oxidoreductase — In biochemistry, an oxidoreductase is an enzyme that catalyzes the transfer of electrons from one molecule (the reductant, also called the hydrogen or electron donor) to another (the oxidant, also called the hydrogen or electron acceptor). This… …   Wikipedia List of enzymes — This article is a list of enzymes, sorted by their respective sub categories and EC number.See also: * List of EC numbers * List of EC numbers (EC 1) * List of EC numbers (EC 2) * List of EC numbers (EC 3) * List of EC numbers (EC 4) * List of EC …   Wikipedia Dihydrolipoamide dehydrogenase — PDB rendering based on 1zy8 …   Wikipedia Metabolism — Cell metabolism redirects here. For the journal, see Cell Metabolism. Structure of adenosine triphosphate, a central intermediate in energy metabolism Metabolism (from Greek: μεταβολή metabolē , change or Greek: μεταβολισμός metabolismos,… …   Wikipedia Corticosteroid 11-beta-dehydrogenase isozyme 2 — Hydroxysteroid (11 beta) dehydrogenase 2 Identifiers Symbols HSD11B2; AME; AME1; HSD11K; HSD2; SDR9C3 External IDs …   Wikipedia 3-beta-HSD — 3β hydroxysteroid dehydrogenase/Δ 5 4 isomerase Identifiers EC number 1.1.1.145 CAS number 9044 85 3 …   Wikipedia Malate dehydrogenase — Structure of the protein with attached sugars Identifiers EC number …   Wikipedia Alcohol dehydrogenase — Crystallographic structure of the homodimer of human ADH5.[1] Identifiers …   Wikipedia 18+ © Academic, 2000-2025 Contact us: Technical Support, Advertising Dictionaries export, created on PHP, Joomla, Drupal, WordPress, MODx. Mark and share Search through all dictionaries Translate… Search Internet Share the article and excerpts Direct link https://en-academic.com/dic.nsf/enwiki/7889121 Do a right-click on the link above and select “Copy Link”