Small Cajal body specific RNA 13
- Small Cajal body specific RNA 13
In molecular biology, Small Cajal body specific RNA 13 (also known as scaRNA13 or U93) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation of U2 and U5 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[cite journal | last = Darzacq | first = X | coauthors = Jady BE, Verheggen C, Kiss AM, Bertrand E, Kiss T | year = 2002 | title = Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs | journal = EMBO J. | volume = 21 | pages = 2746–2756 | pmid = 12032087 | doi = 10.1093/emboj/21.11.2746] ]U93 is composed of two tandemly arranged box H/ACA box sequence motifs and belongs to the H/ACA box class of guide RNAs [cite journal | author = Kiss AM, Jády BE, Darzacq X, Verheggen C, Bertrand E, Kiss T | title = A Cajal body-specific pseudouridylation guide RNA is composed of two box H/ACA snoRNA-like domains | journal = Nucleic Acids Res. | volume = 30 | issue = 21 | pages = 4643–9 | year = 2002 | pmid = 12409454 | doi = | issn = ] . U93 is predicted to guide pseudouridylation of U2 spliceosomal snRNA residue U54 and residue U53 of snRNA U5 ][cite journal | last = Lestrade | first = L | coauthors = Weber MJ | year = 2006 | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Res. | volume = 34 | pages = D158–D162 | pmid = 16381836 | doi = 10.1093/nar/gkj002 ] ][cite journal | author = Schattner P, Barberan-Soler S, Lowe TM | title = A computational screen for mammalian pseudouridylation guide H/ACA RNAs | journal = RNA | volume = 12 | issue = 1 | pages = 15–25 | year = 2006 | pmid = 16373490 | doi = 10.1261/rna.2210406 | issn = ] . ]References
External links
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* [http://www-snorna.biotoul.fr/plus.php?id=U93 snoRNABase entry for SNORD93]
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