U4 spliceosomal RNA

U4 spliceosomal RNA

U4 small nuclear RNA (U4 snRNA) is a non-coding RNA component of the major U2-dependent spliceosome. It forms a duplex with U6, and with each splicing round, it is displaced from U6 (and the spliceosome) in an ATP-dependent manner, allowing U6 to re-fold and create the active site for splicing catalysis. A recycling process involving protein Prp24 re-anneals U4 and U6. The crystal structure of a 5′ stem-loop of U4 in complex with a binding protein has been solved [2] .

References

* [1] cite journal | last = Zwieb | first = C | year = 1997 | title = The uRNA database | journal = Nucleic Acids Res | volume = 25 | pages = 102–103 | pmid = 9016512 | doi = 10.1093/nar/25.1.102
* [2] cite journal | last = Vidovic | first = I | coauthors = Nottrott S, Hartmuth K, Luhrmann R, Ficner R | year = 2000 | title = Crystal structure of the spliceosomal 15.5kD protein bound to a U4 snRNA fragment | journal = Mol Cell | volume = 6 | pages = 1331–1342 | pmid = 11163207 | doi = 10.1016/S1097-2765(00)00131-3
* [3] cite journal | last = Raghunathan | first = PL | coauthors = Guthrie C | year = 1998 | title = A spliceosomal recycling factor that reanneals U4 and U6 small nuclear ribonucleoprotein particles | journal = Science | volume = 279 | pages = 857–860 | pmid = 9452384 | doi = 10.1126/science.279.5352.857
* [4] cite journal | last = Thomas | first = J | coauthors = Lea K, Zucker-Aprison E, Blumenthal T | year = 1990 | title = The spliceosomal snRNAs of Caenorhabditis elegans | journal = Nucleic Acids Res | volume = 18 | pages = 2633–2642 | pmid = 2339054 | doi = 10.1093/nar/18.9.2633

External links

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