Yeast U1 spliceosomal RNA
- Yeast U1 spliceosomal RNA
U1 is a small nuclear RNA (snRNA) component of the spliceosome and is involved in pre-mRNA splicing.
In the splicing process the 5' end of the U1 snRNA forms complementary base pairing with the 5' splice junction of the inton to be excised, thus defining the 5' donor site of an intron.
There are significant differences in sequence and secondary structure between metazoan and yeast U1 snRNAs, the latter being much longer (568 nucleotides as compared to 164 nucleotides in human). Nevertheless, secondary structure predictions suggest that all U1 snRNAs share a 'common core' consisting of helices I, II, the proximal region of III, and IV [cite journal | author = Zwieb C | title = The uRNA database | journal = Nucleic Acids Res. | volume = 25 | issue = 1 | pages = 102–3 | year = 1997 | pmid = 9016512 | doi = 10.1093/nar/25.1.102 ] ][cite journal | author = Kretzner L, Krol A, Rosbash M | title = Saccharomyces cerevisiae U1 small nuclear RNA secondary structure contains both universal and yeast-specific domains | journal = Proc. Natl. Acad. Sci. U.S.A. | volume = 87 | issue = 2 | pages = 851–5 | year = 1990 | pmid = 2405391 | doi = 10.1073/pnas.87.2.851 ] . The secondary structure model shows the structure prediction for the larger yeast sequences. ]References
External links
*
Wikimedia Foundation.
2010.
Look at other dictionaries:
U1 spliceosomal RNA — is a small nuclear RNA (snRNA) component of the spliceosome (involved in pre mRNA splicing). Its 5 end forms complementary base pairs with the 5 splice junction, thus defining the 5 donor site of an intron. There are significant differences in… … Wikipedia
RNA splicing — In molecular biology and genetics, splicing is a modification of an RNA after transcription, in which introns are removed and exons are joined. This is needed for the typical eukaryotic messenger RNA before it can be used to produce a correct… … Wikipedia
ARN splicéosomal U6 — Un ARNsn U6. Les parties rouges sont les parties invariantes. L’ARN splicéosomal U6 est un petit ARN nucléaire (snRNA ou ARNpn) entrant dans la composition des petites ribonucléoprotéines nucléaires U6. Il se combine avec d autres RNPsn, de l ARN … Wikipédia en Français
U2 small nuclear RNA auxiliary factor 1 — U2 small nuclear RNA auxiliary factor 1, also known as U2AF1, is a human gene.cite web | title = Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView… … Wikipedia
Spliceosome — A spliceosome is a complex of specialized RNA and protein subunits that removes introns from a transcribed pre mRNA (hnRNA)segment. This process is generally referred to as splicing. CompositionEach spliceosome is composed of five small nuclear… … Wikipedia
RBM39 — RNA binding motif protein 39, also known as RBM39, is a human gene.cite web | title = Entrez Gene: RBM39 RNA binding motif protein 39| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=9584| accessdate = ] PBB … Wikipedia
LSm — s.The Sm proteins were first discovered as antigens in a patient with a form of systemic lupus erythematosus (SLE), a debilitating autoimmune disease. They were named Sm proteins in honor of this patient, Stephanie Smith. Other proteins with very … Wikipedia
DDX20 — DEAD (Asp Glu Ala Asp) box polypeptide 20 PDB rendering based on 2oxc … Wikipedia
SF3A2 — Splicing factor 3a, subunit 2, 66kDa, also known as SF3A2, is a human gene.cite web | title = Entrez Gene: SF3A2 splicing factor 3a, subunit 2, 66kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=8175|… … Wikipedia
PRPF4 — PRP4 pre mRNA processing factor 4 homolog (yeast), also known as PRPF4, is a human gene.cite web | title = Entrez Gene: PRPF4 PRP4 pre mRNA processing factor 4 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… … Wikipedia
