DDX20

DDX20
DEAD (Asp-Glu-Ala-Asp) box polypeptide 20

PDB rendering based on 2oxc.
Identifiers
Symbols DDX20; DKFZp434H052; DP103; GEMIN3
External IDs OMIM606168 MGI1858415 HomoloGene5214 GeneCards: DDX20 Gene
EC number 3.6.4.13
RNA expression pattern
PBB GE DDX20 gnf1h00107 at tn.png
More reference expression data
Orthologs
Species Human Mouse
Entrez 11218 53975
Ensembl ENSG00000064703 ENSMUSG00000027905
UniProt Q9UHI6 Q059Z6
RefSeq (mRNA) NM_007204 NM_017397.3
RefSeq (protein) NP_009135 NP_059093.3
Location (UCSC) Chr 1:
112.3 – 112.31 Mb
Chr 3:
105.48 – 105.49 Mb
PubMed search [1] [2]

Probable ATP-dependent RNA helicase DDX20 is an enzyme that in humans is encoded by the DDX20 gene.[1][2]

DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. This gene encodes a DEAD box protein, which has an ATPase activity and is a component of the survival of motor neurons (SMN) complex. This protein interacts directly with SMN, the spinal muscular atrophy gene product, and may play a catalytic role in the function of the SMN complex on RNPs.[2]

Interactions

DDX20 has been shown to interact with LSM2,[3] Small nuclear ribonucleoprotein polypeptide F,[3] SNRPG,[3] GEMIN4,[4][5][6] Survival of motor neuron protein-interacting protein 1,[6][3] SMN1,[4][7][6][3] Small nuclear ribonucleoprotein D1,[3] SNRPB,[3] GEMIN5,[8][6] EIF2C2,[9][6] Small nuclear ribonucleoprotein D2,[3] SNRPD3[3] and Small nuclear ribonucleoprotein polypeptide E.[3]

References

  1. ^ Grundhoff AT, Kremmer E, Tureci O, Glieden A, Gindorf C, Atz J, Mueller-Lantzsch N, Schubach WH, Grasser FA (Jul 1999). "Characterization of DP103, a novel DEAD box protein that binds to the Epstein-Barr virus nuclear proteins EBNA2 and EBNA3C". J Biol Chem 274 (27): 19136–44. doi:10.1074/jbc.274.27.19136. PMID 10383418. 
  2. ^ a b "Entrez Gene: DDX20 DEAD (Asp-Glu-Ala-Asp) box polypeptide 20". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=11218. 
  3. ^ a b c d e f g h i j Charroux, B; Pellizzoni L, Perkinson R A, Shevchenko A, Mann M, Dreyfuss G (Dec. 1999). "Gemin3: A novel DEAD box protein that interacts with SMN, the spinal muscular atrophy gene product, and is a component of gems". J. Cell Biol. (UNITED STATES) 147 (6): 1181–94. doi:10.1083/jcb.147.6.1181. ISSN 0021-9525. PMC 2168095. PMID 10601333. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2168095. 
  4. ^ a b Carnegie, Graeme K; Sleeman Judith E, Morrice Nick, Hastie C James, Peggie Mark W, Philp Amanda, Lamond Angus I, Cohen Patricia T W (May. 2003). "Protein phosphatase 4 interacts with the Survival of Motor Neurons complex and enhances the temporal localisation of snRNPs". J. Cell. Sci. (England) 116 (Pt 10): 1905–13. doi:10.1242/jcs.00409. ISSN 0021-9533. PMID 12668731. 
  5. ^ Charroux, B; Pellizzoni L, Perkinson R A, Yong J, Shevchenko A, Mann M, Dreyfuss G (Mar. 2000). "Gemin4. A novel component of the SMN complex that is found in both gems and nucleoli". J. Cell Biol. (UNITED STATES) 148 (6): 1177–86. doi:10.1083/jcb.148.6.1177. ISSN 0021-9525. PMC 2174312. PMID 10725331. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=2174312. 
  6. ^ a b c d e Mourelatos, Zissimos; Dostie Josée, Paushkin Sergey, Sharma Anup, Charroux Bernard, Abel Linda, Rappsilber Juri, Mann Matthias, Dreyfuss Gideon (Mar. 2002). "miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs". Genes Dev. (United States) 16 (6): 720–8. doi:10.1101/gad.974702. ISSN 0890-9369. PMC 155365. PMID 11914277. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=155365. 
  7. ^ Meister, G; Bühler D, Laggerbauer B, Zobawa M, Lottspeich F, Fischer U (Aug. 2000). "Characterization of a nuclear 20S complex containing the survival of motor neurons (SMN) protein and a specific subset of spliceosomal Sm proteins". Hum. Mol. Genet. (ENGLAND) 9 (13): 1977–86. doi:10.1093/hmg/9.13.1977. ISSN 0964-6906. PMID 10942426. 
  8. ^ Gubitz, Amelie K; Mourelatos Zissimos, Abel Linda, Rappsilber Juri, Mann Matthias, Dreyfuss Gideon (Feb. 2002). "Gemin5, a novel WD repeat protein component of the SMN complex that binds Sm proteins". J. Biol. Chem. (United States) 277 (7): 5631–6. doi:10.1074/jbc.M109448200. ISSN 0021-9258. PMID 11714716. 
  9. ^ Nelson, Peter T; Hatzigeorgiou Artemis G, Mourelatos Zissimos (Mar. 2004). "miRNP:mRNA association in polyribosomes in a human neuronal cell line". RNA (United States) 10 (3): 387–94. doi:10.1261/rna.5181104. ISSN 1355-8382. PMC 1370934. PMID 14970384. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1370934. 

Further reading


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