EIF2C2

Eukaryotic translation initiation factor 2C, 2, also known as EIF2C2, is a human gene.cite web | title = Entrez Gene: EIF2C2 eukaryotic translation initiation factor 2C, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27161| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the Argonaute family of proteins which play a role in RNA interference. The encoded protein is highly basic, and contains a PAZ domain and a PIWI domain. It may interact with dicer1 and play a role in short-interfering-RNA-mediated gene silencing.cite web | title = Entrez Gene: EIF2C2 eukaryotic translation initiation factor 2C, 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=27161| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Carmell MA, Xuan Z, Zhang MQ, Hannon GJ |title=The Argonaute family: tentacles that reach into RNAi, developmental control, stem cell maintenance, and tumorigenesis. |journal=Genes Dev. |volume=16 |issue= 21 |pages= 2733–42 |year= 2002 |pmid= 12414724 |doi= 10.1101/gad.1026102
*cite journal | author=Koesters R, Adams V, Betts D, "et al." |title=Human eukaryotic initiation factor EIF2C1 gene: cDNA sequence, genomic organization, localization to chromosomal bands 1p34-p35, and expression. |journal=Genomics |volume=61 |issue= 2 |pages= 210–8 |year= 1999 |pmid= 10534406 |doi= 10.1006/geno.1999.5951
*cite journal | author=Mourelatos Z, Dostie J, Paushkin S, "et al." |title=miRNPs: a novel class of ribonucleoproteins containing numerous microRNAs. |journal=Genes Dev. |volume=16 |issue= 6 |pages= 720–8 |year= 2002 |pmid= 11914277 |doi= 10.1101/gad.974702
*cite journal | author=Martinez J, Patkaniowska A, Urlaub H, "et al." |title=Single-stranded antisense siRNAs guide target RNA cleavage in RNAi. |journal=Cell |volume=110 |issue= 5 |pages= 563–74 |year= 2003 |pmid= 12230974 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Doi N, Zenno S, Ueda R, "et al." |title=Short-interfering-RNA-mediated gene silencing in mammalian cells requires Dicer and eIF2C translation initiation factors. |journal=Curr. Biol. |volume=13 |issue= 1 |pages= 41–6 |year= 2003 |pmid= 12526743 |doi=
*cite journal | author=Sasaki T, Shiohama A, Minoshima S, Shimizu N |title=Identification of eight members of the Argonaute family in the human genome small star, filled. |journal=Genomics |volume=82 |issue= 3 |pages= 323–30 |year= 2004 |pmid= 12906857 |doi=
*cite journal | author=Tahbaz N, Kolb FA, Zhang H, "et al." |title=Characterization of the interactions between mammalian PAZ PIWI domain proteins and Dicer. |journal=EMBO Rep. |volume=5 |issue= 2 |pages= 189–94 |year= 2004 |pmid= 14749716 |doi= 10.1038/sj.embor.7400070
*cite journal | author=Nelson PT, Hatzigeorgiou AG, Mourelatos Z |title=miRNP:mRNA association in polyribosomes in a human neuronal cell line. |journal=RNA |volume=10 |issue= 3 |pages= 387–94 |year= 2004 |pmid= 14970384 |doi=
*cite journal | author=Liu J, Carmell MA, Rivas FV, "et al." |title=Argonaute2 is the catalytic engine of mammalian RNAi. |journal=Science |volume=305 |issue= 5689 |pages= 1437–41 |year= 2004 |pmid= 15284456 |doi= 10.1126/science.1102513
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Rivas FV, Tolia NH, Song JJ, "et al." |title=Purified Argonaute2 and an siRNA form recombinant human RISC. |journal=Nat. Struct. Mol. Biol. |volume=12 |issue= 4 |pages= 340–9 |year= 2005 |pmid= 15800637 |doi= 10.1038/nsmb918
*cite journal | author=Sen GL, Blau HM |title=Argonaute 2/RISC resides in sites of mammalian mRNA decay known as cytoplasmic bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 6 |pages= 633–6 |year= 2005 |pmid= 15908945 |doi= 10.1038/ncb1265
*cite journal | author=Liu J, Valencia-Sanchez MA, Hannon GJ, Parker R |title=MicroRNA-dependent localization of targeted mRNAs to mammalian P-bodies. |journal=Nat. Cell Biol. |volume=7 |issue= 7 |pages= 719–23 |year= 2005 |pmid= 15937477 |doi= 10.1038/ncb1274
*cite journal | author=Rual JF, Venkatesan K, Hao T, "et al." |title=Towards a proteome-scale map of the human protein-protein interaction network. |journal=Nature |volume=437 |issue= 7062 |pages= 1173–8 |year= 2005 |pmid= 16189514 |doi= 10.1038/nature04209
*cite journal | author=Kraynack BA, Baker BF |title=Small interfering RNAs containing full 2'-O-methylribonucleotide-modified sense strands display Argonaute2/eIF2C2-dependent activity. |journal=RNA |volume=12 |issue= 1 |pages= 163–76 |year= 2006 |pmid= 16301602 |doi= 10.1261/rna.2150806
*cite journal | author=Maniataki E, Mourelatos Z |title=A human, ATP-independent, RISC assembly machine fueled by pre-miRNA. |journal=Genes Dev. |volume=19 |issue= 24 |pages= 2979–90 |year= 2006 |pmid= 16357216 |doi= 10.1101/gad.1384005
*cite journal | author=Shi H, Tschudi C, Ullu E |title=Functional replacement of Trypanosoma brucei Argonaute by the human slicer Argonaute2. |journal=RNA |volume=12 |issue= 6 |pages= 943–7 |year= 2006 |pmid= 16611939 |doi= 10.1261/rna.20806
*cite journal | author=Wichroski MJ, Robb GB, Rana TM |title=Human retroviral host restriction factors APOBEC3G and APOBEC3F localize to mRNA processing bodies. |journal=PLoS Pathog. |volume=2 |issue= 5 |pages= e41 |year= 2006 |pmid= 16699599 |doi= 10.1371/journal.ppat.0020041

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes