U2 small nuclear RNA auxiliary factor 1

U2 small nuclear RNA auxiliary factor 1

U2 small nuclear RNA auxiliary factor 1, also known as U2AF1, is a human gene.cite web | title = Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7307| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene belongs to the splicing factor SR family of genes. U2 auxiliary factor, comprising a large and a small subunit, is a non-snRNP protein required for the binding of U2 snRNP to the pre-mRNA branch site. This gene encodes the small subunit which plays a critical role in both constitutive and enhancer-dependent RNA splicing by directly mediating interactions between the large subunit and proteins bound to the enhancers. Alternatively spliced transcript variants encoding different isoforms have been identified.cite web | title = Entrez Gene: U2AF1 U2 small nuclear RNA auxiliary factor 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=7307| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Zhang M, Zamore PD, Carmo-Fonseca M, "et al." |title=Cloning and intracellular localization of the U2 small nuclear ribonucleoprotein auxiliary factor small subunit. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=89 |issue= 18 |pages= 8769–73 |year= 1992 |pmid= 1388271 |doi=
*cite journal | author=Zamore PD, Green MR |title=Biochemical characterization of U2 snRNP auxiliary factor: an essential pre-mRNA splicing factor with a novel intranuclear distribution. |journal=EMBO J. |volume=10 |issue= 1 |pages= 207–14 |year= 1991 |pmid= 1824937 |doi=
*cite journal | author=Kalcheva I, Plass C, Sait S, "et al." |title=Comparative mapping of the imprinted U2afbpL gene on mouse chromosome 11 and human chromosome 5. |journal=Cytogenet. Cell Genet. |volume=68 |issue= 1-2 |pages= 19–24 |year= 1994 |pmid= 7956352 |doi=
*cite journal | author=Wu JY, Maniatis T |title=Specific interactions between proteins implicated in splice site selection and regulated alternative splicing. |journal=Cell |volume=75 |issue= 6 |pages= 1061–70 |year= 1994 |pmid= 8261509 |doi=
*cite journal | author=Zuo P, Maniatis T |title=The splicing factor U2AF35 mediates critical protein-protein interactions in constitutive and enhancer-dependent splicing. |journal=Genes Dev. |volume=10 |issue= 11 |pages= 1356–68 |year= 1996 |pmid= 8647433 |doi=
*cite journal | author=Lalioti MD, Gos A, Green MR, "et al." |title=The gene for human U2 snRNP auxiliary factor small 35-kDa subunit (U2AF1) maps to the progressive myoclonus epilepsy (EPM1) critical region on chromosome 21q22.3. |journal=Genomics |volume=33 |issue= 2 |pages= 298–300 |year= 1997 |pmid= 8660980 |doi= 10.1006/geno.1996.0196
*cite journal | author=Hong W, Bennett M, Xiao Y, "et al." |title=Association of U2 snRNP with the spliceosomal complex E. |journal=Nucleic Acids Res. |volume=25 |issue= 2 |pages= 354–61 |year= 1997 |pmid= 9016565 |doi=
*cite journal | author=Tronchère H, Wang J, Fu XD |title=A protein related to splicing factor U2AF35 that interacts with U2AF65 and SR proteins in splicing of pre-mRNA. |journal=Nature |volume=388 |issue= 6640 |pages= 397–400 |year= 1997 |pmid= 9237760 |doi= 10.1038/41137
*cite journal | author=Wang HY, Lin W, Dyck JA, "et al." |title=SRPK2: a differentially expressed SR protein-specific kinase involved in mediating the interaction and localization of pre-mRNA splicing factors in mammalian cells. |journal=J. Cell Biol. |volume=140 |issue= 4 |pages= 737–50 |year= 1998 |pmid= 9472028 |doi=
*cite journal | author=Rudner DZ, Kanaar R, Breger KS, Rio DC |title=Interaction between subunits of heterodimeric splicing factor U2AF is essential in vivo. |journal=Mol. Cell. Biol. |volume=18 |issue= 4 |pages= 1765–73 |year= 1998 |pmid= 9528748 |doi=
*cite journal | author=Lallena MJ, Martínez C, Valcárcel J, Correas I |title=Functional association of nuclear protein 4.1 with pre-mRNA splicing factors. |journal=J. Cell. Sci. |volume=111 ( Pt 14) |issue= |pages= 1963–71 |year= 1998 |pmid= 9645944 |doi=
*cite journal | author=Gozani O, Potashkin J, Reed R |title=A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site. |journal=Mol. Cell. Biol. |volume=18 |issue= 8 |pages= 4752–60 |year= 1998 |pmid= 9671485 |doi=
*cite journal | author=Neubauer G, King A, Rappsilber J, "et al." |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700
*cite journal | author=Xiao SH, Manley JL |title=Phosphorylation-dephosphorylation differentially affects activities of splicing factor ASF/SF2. |journal=EMBO J. |volume=17 |issue= 21 |pages= 6359–67 |year= 1999 |pmid= 9799243 |doi= 10.1093/emboj/17.21.6359
*cite journal | author=Hattori M, Fujiyama A, Taylor TD, "et al." |title=The DNA sequence of human chromosome 21. |journal=Nature |volume=405 |issue= 6784 |pages= 311–9 |year= 2000 |pmid= 10830953 |doi= 10.1038/35012518
*cite journal | author=de Vries H, Rüegsegger U, Hübner W, "et al." |title=Human pre-mRNA cleavage factor II(m) contains homologs of yeast proteins and bridges two other cleavage factors. |journal=EMBO J. |volume=19 |issue= 21 |pages= 5895–904 |year= 2000 |pmid= 11060040 |doi= 10.1093/emboj/19.21.5895
*cite journal | author=Gama-Carvalho M, Carvalho MP, Kehlenbach A, "et al." |title=Nucleocytoplasmic shuttling of heterodimeric splicing factor U2AF. |journal=J. Biol. Chem. |volume=276 |issue= 16 |pages= 13104–12 |year= 2001 |pmid= 11118443 |doi= 10.1074/jbc.M008759200
*cite journal | author=Adams DJ, van der Weyden L, Mayeda A, "et al." |title=ZNF265--a novel spliceosomal protein able to induce alternative splicing. |journal=J. Cell Biol. |volume=154 |issue= 1 |pages= 25–32 |year= 2001 |pmid= 11448987 |doi=
*cite journal | author=Will CL, Schneider C, MacMillan AM, "et al." |title=A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4536–46 |year= 2001 |pmid= 11500380 |doi= 10.1093/emboj/20.16.4536
*cite journal | author=Nesic D, Krämer A |title=Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. |journal=Mol. Cell. Biol. |volume=21 |issue= 19 |pages= 6406–17 |year= 2001 |pmid= 11533230 |doi=

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