TAF9

TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa, also known as TAF9, is a human gene.cite web | title = Entrez Gene: TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6880| accessdate = ]

PBB_Summary
section_title =
summary_text = Initiation of transcription by RNA polymerase II requires the activities of more than 70 polypeptides. The protein that coordinates these activities is transcription factor IID (TFIID), which binds to the core promoter to position the polymerase properly, serves as the scaffold for assembly of the remainder of the transcription complex, and acts as a channel for regulatory signals. TFIID is composed of the TATA-binding protein (TBP) and a group of evolutionarily conserved proteins known as TBP-associated factors or TAFs. TAFs may participate in basal transcription, serve as coactivators, function in promoter recognition or modify general transcription factors (GTFs) to facilitate complex assembly and transcription initiation. This gene encodes one of the smaller subunits of TFIID that binds to the basal transcription factor GTF2B as well as to several transcriptional activators such as p53 and VP16. A similar but distinct gene (TAF9L) has been found on the X chromosome and a pseudogene has been identified on chromosome 19. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: TAF9 TAF9 RNA polymerase II, TATA box binding protein (TBP)-associated factor, 32kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=6880| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Klemm RD, Goodrich JA, Zhou S, Tjian R |title=Molecular cloning and expression of the 32-kDa subunit of human TFIID reveals interactions with VP16 and TFIIB that mediate transcriptional activation. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 13 |pages= 5788–92 |year= 1995 |pmid= 7597030 |doi=
*cite journal | author=Hisatake K, Ohta T, Takada R, "et al." |title=Evolutionary conservation of human TATA-binding-polypeptide-associated factors TAFII31 and TAFII80 and interactions of TAFII80 with other TAFs and with general transcription factors. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 18 |pages= 8195–9 |year= 1995 |pmid= 7667268 |doi=
*cite journal | author=Lu H, Levine AJ |title=Human TAFII31 protein is a transcriptional coactivator of the p53 protein. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=92 |issue= 11 |pages= 5154–8 |year= 1995 |pmid= 7761466 |doi=
*cite journal | author=Thut CJ, Chen JL, Klemm R, Tjian R |title=p53 transcriptional activation mediated by coactivators TAFII40 and TAFII60. |journal=Science |volume=267 |issue= 5194 |pages= 100–4 |year= 1995 |pmid= 7809597 |doi=
*cite journal | author=Zhou Q, Sharp PA |title=Novel mechanism and factor for regulation by HIV-1 Tat. |journal=EMBO J. |volume=14 |issue= 2 |pages= 321–8 |year= 1995 |pmid= 7835343 |doi=
*cite journal | author=Parada CA, Yoon JB, Roeder RG |title=A novel LBP-1-mediated restriction of HIV-1 transcription at the level of elongation in vitro. |journal=J. Biol. Chem. |volume=270 |issue= 5 |pages= 2274–83 |year= 1995 |pmid= 7836461 |doi=
*cite journal | author=Ou SH, Garcia-Martínez LF, Paulssen EJ, Gaynor RB |title=Role of flanking E box motifs in human immunodeficiency virus type 1 TATA element function. |journal=J. Virol. |volume=68 |issue= 11 |pages= 7188–99 |year= 1994 |pmid= 7933101 |doi=
*cite journal | author=Kashanchi F, Piras G, Radonovich MF, "et al." |title=Direct interaction of human TFIID with the HIV-1 transactivator tat. |journal=Nature |volume=367 |issue= 6460 |pages= 295–9 |year= 1994 |pmid= 8121496 |doi= 10.1038/367295a0
*cite journal | author=Adams MD, Soares MB, Kerlavage AR, "et al." |title=Rapid cDNA sequencing (expressed sequence tags) from a directionally cloned human infant brain cDNA library. |journal=Nat. Genet. |volume=4 |issue= 4 |pages= 373–80 |year= 1993 |pmid= 8401585 |doi= 10.1038/ng0893-373
*cite journal | author=Wang Z, Morris GF, Rice AP, "et al." |title=Wild-type and transactivation-defective mutants of human immunodeficiency virus type 1 Tat protein bind human TATA-binding protein in vitro. |journal=J. Acquir. Immune Defic. Syndr. Hum. Retrovirol. |volume=12 |issue= 2 |pages= 128–38 |year= 1996 |pmid= 8680883 |doi=
*cite journal | author=Pendergrast PS, Morrison D, Tansey WP, Hernandez N |title=Mutations in the carboxy-terminal domain of TBP affect the synthesis of human immunodeficiency virus type 1 full-length and short transcripts similarly. |journal=J. Virol. |volume=70 |issue= 8 |pages= 5025–34 |year= 1996 |pmid= 8764009 |doi=
*cite journal | author=Kashanchi F, Khleif SN, Duvall JF, "et al." |title=Interaction of human immunodeficiency virus type 1 Tat with a unique site of TFIID inhibits negative cofactor Dr1 and stabilizes the TFIID-TFIIA complex. |journal=J. Virol. |volume=70 |issue= 8 |pages= 5503–10 |year= 1996 |pmid= 8764062 |doi=
*cite journal | author=Zhou Q, Sharp PA |title=Tat-SF1: cofactor for stimulation of transcriptional elongation by HIV-1 Tat. |journal=Science |volume=274 |issue= 5287 |pages= 605–10 |year= 1996 |pmid= 8849451 |doi=
*cite journal | author=Tao Y, Guermah M, Martinez E, "et al." |title=Specific interactions and potential functions of human TAFII100. |journal=J. Biol. Chem. |volume=272 |issue= 10 |pages= 6714–21 |year= 1997 |pmid= 9045704 |doi=
*cite journal | author=García-Martínez LF, Ivanov D, Gaynor RB |title=Association of Tat with purified HIV-1 and HIV-2 transcription preinitiation complexes. |journal=J. Biol. Chem. |volume=272 |issue= 11 |pages= 6951–8 |year= 1997 |pmid= 9054383 |doi=
*cite journal | author=Ogryzko VV, Kotani T, Zhang X, "et al." |title=Histone-like TAFs within the PCAF histone acetylase complex. |journal=Cell |volume=94 |issue= 1 |pages= 35–44 |year= 1998 |pmid= 9674425 |doi=
*cite journal | author=Vassilev A, Yamauchi J, Kotani T, "et al." |title=The 400 kDa subunit of the PCAF histone acetylase complex belongs to the ATM superfamily. |journal=Mol. Cell |volume=2 |issue= 6 |pages= 869–75 |year= 1999 |pmid= 9885574 |doi=
*cite journal | author=Evans SC, Foster CJ, El-Naggar AK, Lozano G |title=Mapping and mutational analysis of the human TAF2G gene encoding a p53 cofactor. |journal=Genomics |volume=57 |issue= 1 |pages= 182–3 |year= 1999 |pmid= 10191103 |doi= 10.1006/geno.1999.5745
*cite journal | author=Lai CH, Chou CY, Ch'ang LY, "et al." |title=Identification of novel human genes evolutionarily conserved in Caenorhabditis elegans by comparative proteomics. |journal=Genome Res. |volume=10 |issue= 5 |pages= 703–13 |year= 2000 |pmid= 10810093 |doi=
*cite journal | author=Choi Y, Asada S, Uesugi M |title=Divergent hTAFII31-binding motifs hidden in activation domains. |journal=J. Biol. Chem. |volume=275 |issue= 21 |pages= 15912–6 |year= 2000 |pmid= 10821850 |doi=

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