SF3B1

Splicing factor 3b, subunit 1, 155kDa, also known as SF3B1, is a human gene.cite web | title = Entrez Gene: SF3B1 splicing factor 3b, subunit 1, 155kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23451| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes subunit 1 of the splicing factor 3b protein complex. Splicing factor 3b, together with splicing factor 3a and a 12S RNA unit, forms the U2 small nuclear ribonucleoproteins complex (U2 snRNP). The splicing factor 3b/3a complex binds pre-mRNA upstream of the intron's branch site in a sequence independent manner and may anchor the U2 snRNP to the pre-mRNA. Splicing factor 3b is also a component of the minor U12-type spliceosome. The carboxy-terminal two-thirds of subunit 1 have 22 non-identical, tandem HEAT repeats that form rod-like, helical structures. Alternative splicing results in multiple transcript variants encoding different isoforms.cite web | title = Entrez Gene: SF3B1 splicing factor 3b, subunit 1, 155kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=23451| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Andersson B, Wentland MA, Ricafrente JY, "et al." |title=A "double adaptor" method for improved shotgun library construction. |journal=Anal. Biochem. |volume=236 |issue= 1 |pages= 107–13 |year= 1996 |pmid= 8619474 |doi= 10.1006/abio.1996.0138
*cite journal | author=Yu W, Andersson B, Worley KC, "et al." |title=Large-scale concatenation cDNA sequencing. |journal=Genome Res. |volume=7 |issue= 4 |pages= 353–8 |year= 1997 |pmid= 9110174 |doi=
*cite journal | author=Wang C, Chua K, Seghezzi W, "et al." |title=Phosphorylation of spliceosomal protein SAP 155 coupled with splicing catalysis. |journal=Genes Dev. |volume=12 |issue= 10 |pages= 1409–14 |year= 1998 |pmid= 9585501 |doi=
*cite journal | author=Gozani O, Potashkin J, Reed R |title=A potential role for U2AF-SAP 155 interactions in recruiting U2 snRNP to the branch site. |journal=Mol. Cell. Biol. |volume=18 |issue= 8 |pages= 4752–60 |year= 1998 |pmid= 9671485 |doi=
*cite journal | author=Das BK, Xia L, Palandjian L, "et al." |title=Characterization of a protein complex containing spliceosomal proteins SAPs 49, 130, 145, and 155. |journal=Mol. Cell. Biol. |volume=19 |issue= 10 |pages= 6796–802 |year= 2000 |pmid= 10490618 |doi=
*cite journal | author=Pauling MH, McPheeters DS, Ares M |title=Functional Cus1p is found with Hsh155p in a multiprotein splicing factor associated with U2 snRNA. |journal=Mol. Cell. Biol. |volume=20 |issue= 6 |pages= 2176–85 |year= 2000 |pmid= 10688664 |doi=
*cite journal | author=Dias Neto E, Correa RG, Verjovski-Almeida S, "et al." |title=Shotgun sequencing of the human transcriptome with ORF expressed sequence tags. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=97 |issue= 7 |pages= 3491–6 |year= 2000 |pmid= 10737800 |doi=
*cite journal | author=Das R, Zhou Z, Reed R |title=Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. |journal=Mol. Cell |volume=5 |issue= 5 |pages= 779–87 |year= 2000 |pmid= 10882114 |doi=
*cite journal | author=Brand M, Moggs JG, Oulad-Abdelghani M, "et al." |title=UV-damaged DNA-binding protein in the TFTC complex links DNA damage recognition to nucleosome acetylation. |journal=EMBO J. |volume=20 |issue= 12 |pages= 3187–96 |year= 2001 |pmid= 11406595 |doi= 10.1093/emboj/20.12.3187
*cite journal | author=Will CL, Schneider C, MacMillan AM, "et al." |title=A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4536–46 |year= 2001 |pmid= 11500380 |doi= 10.1093/emboj/20.16.4536
*cite journal | author=Jurica MS, Licklider LJ, Gygi SR, "et al." |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=
*cite journal | author=Boudrez A, Beullens M, Waelkens E, "et al." |title=Phosphorylation-dependent interaction between the splicing factors SAP155 and NIPP1. |journal=J. Biol. Chem. |volume=277 |issue= 35 |pages= 31834–41 |year= 2002 |pmid= 12105215 |doi= 10.1074/jbc.M204427200
*cite journal | author=Will CL, Urlaub H, Achsel T, "et al." |title=Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. |journal=EMBO J. |volume=21 |issue= 18 |pages= 4978–88 |year= 2002 |pmid= 12234937 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Golas MM, Sander B, Will CL, "et al." |title=Molecular architecture of the multiprotein splicing factor SF3b. |journal=Science |volume=300 |issue= 5621 |pages= 980–4 |year= 2003 |pmid= 12738865 |doi= 10.1126/science.1084155
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Banerjee H, Rahn A, Gawande B, "et al." |title=The conserved RNA recognition motif 3 of U2 snRNA auxiliary factor (U2AF 65) is essential in vivo but dispensable for activity in vitro. |journal=RNA |volume=10 |issue= 2 |pages= 240–53 |year= 2004 |pmid= 14730023 |doi=
*cite journal | author=Will CL, Schneider C, Hossbach M, "et al." |title=The human 18S U11/U12 snRNP contains a set of novel proteins not found in the U2-dependent spliceosome. |journal=RNA |volume=10 |issue= 6 |pages= 929–41 |year= 2004 |pmid= 15146077 |doi=
*cite journal | author=Beausoleil SA, Jedrychowski M, Schwartz D, "et al." |title=Large-scale characterization of HeLa cell nuclear phosphoproteins. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=101 |issue= 33 |pages= 12130–5 |year= 2004 |pmid= 15302935 |doi= 10.1073/pnas.0404720101
*cite journal | author=Lin KT, Lu RM, Tarn WY |title=The WW domain-containing proteins interact with the early spliceosome and participate in pre-mRNA splicing in vivo. |journal=Mol. Cell. Biol. |volume=24 |issue= 20 |pages= 9176–85 |year= 2004 |pmid= 15456888 |doi= 10.1128/MCB.24.20.9176-9185.2004

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