SF3A2

Splicing factor 3a, subunit 2, 66kDa, also known as SF3A2, is a human gene.cite web | title = Entrez Gene: SF3A2 splicing factor 3a, subunit 2, 66kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8175| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes subunit 2 of the splicing factor 3a protein complex. The splicing factor 3a heterotrimer includes subunits 1, 2 and 3 and is necessary for the in vitro conversion of 15S U2 snRNP into an active 17S particle that performs pre-mRNA splicing. Subunit 2 interacts with subunit 1 through its amino-terminus while the single zinc finger domain of subunit 2 plays a role in its binding to the 15S U2 snRNP. Subunit 2 may also function independently of its RNA splicing function as a microtubule-binding protein.cite web | title = Entrez Gene: SF3A2 splicing factor 3a, subunit 2, 66kDa| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8175| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Chiara MD, Champion-Arnaud P, Buvoli M, "et al." |title=Specific protein-protein interactions between the essential mammalian spliceosome-associated proteins SAP 61 and SAP 114. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=91 |issue= 14 |pages= 6403–7 |year= 1994 |pmid= 8022796 |doi=
*cite journal | author=Bennett M, Reed R |title=Correspondence between a mammalian spliceosome component and an essential yeast splicing factor. |journal=Science |volume=262 |issue= 5130 |pages= 105–8 |year= 1993 |pmid= 8211113 |doi=
*cite journal | author=Dresser DW, Hacker A, Lovell-Badge R, Guerrier D |title=The genes for a spliceosome protein (SAP62) and the anti-Müllerian hormone (AMH) are contiguous. |journal=Hum. Mol. Genet. |volume=4 |issue= 9 |pages= 1613–8 |year= 1996 |pmid= 8541848 |doi=
*cite journal | author=Rain JC, Tartakoff AM, Krämer A, Legrain P |title=Essential domains of the PRP21 splicing factor are implicated in the binding to PRP9 and PRP11 proteins and are conserved through evolution. |journal=RNA |volume=2 |issue= 6 |pages= 535–50 |year= 1996 |pmid= 8718683 |doi=
*cite journal | author=Hong W, Bennett M, Xiao Y, "et al." |title=Association of U2 snRNP with the spliceosomal complex E. |journal=Nucleic Acids Res. |volume=25 |issue= 2 |pages= 354–61 |year= 1997 |pmid= 9016565 |doi=
*cite journal | author=Moraitou M, Patrinou-Georgoula M, Guialis A |title=Structural/functional properties of a mammalian multi-component structure containing all major spliceosomal small nuclear ribonucleoprotein particles. |journal=Biochem. J. |volume=332 ( Pt 1) |issue= |pages= 135–44 |year= 1998 |pmid= 9576861 |doi=
*cite journal | author=Yan D, Perriman R, Igel H, "et al." |title=CUS2, a yeast homolog of human Tat-SF1, rescues function of misfolded U2 through an unusual RNA recognition motif. |journal=Mol. Cell. Biol. |volume=18 |issue= 9 |pages= 5000–9 |year= 1998 |pmid= 9710584 |doi=
*cite journal | author=Neubauer G, King A, Rappsilber J, "et al." |title=Mass spectrometry and EST-database searching allows characterization of the multi-protein spliceosome complex. |journal=Nat. Genet. |volume=20 |issue= 1 |pages= 46–50 |year= 1998 |pmid= 9731529 |doi= 10.1038/1700
*cite journal | author=Krämer A, Grüter P, Gröning K, Kastner B |title=Combined biochemical and electron microscopic analyses reveal the architecture of the mammalian U2 snRNP. |journal=J. Cell Biol. |volume=145 |issue= 7 |pages= 1355–68 |year= 1999 |pmid= 10385517 |doi=
*cite journal | author=Das R, Zhou Z, Reed R |title=Functional association of U2 snRNP with the ATP-independent spliceosomal complex E. |journal=Mol. Cell |volume=5 |issue= 5 |pages= 779–87 |year= 2000 |pmid= 10882114 |doi=
*cite journal | author=Will CL, Schneider C, MacMillan AM, "et al." |title=A novel U2 and U11/U12 snRNP protein that associates with the pre-mRNA branch site. |journal=EMBO J. |volume=20 |issue= 16 |pages= 4536–46 |year= 2001 |pmid= 11500380 |doi= 10.1093/emboj/20.16.4536
*cite journal | author=Nesic D, Krämer A |title=Domains in human splicing factors SF3a60 and SF3a66 required for binding to SF3a120, assembly of the 17S U2 snRNP, and prespliceosome formation. |journal=Mol. Cell. Biol. |volume=21 |issue= 19 |pages= 6406–17 |year= 2001 |pmid= 11533230 |doi=
*cite journal | author=Dresser DW, Jamin SP, Atkins CJ, Guerrier D |title=An expressed GNRP-like gene shares a bi-directional promoter with SF3A2 (SAP62) immediately upstream of AMH. |journal=Gene |volume=277 |issue= 1-2 |pages= 163–73 |year= 2001 |pmid= 11602354 |doi=
*cite journal | author=Jurica MS, Licklider LJ, Gygi SR, "et al." |title=Purification and characterization of native spliceosomes suitable for three-dimensional structural analysis. |journal=RNA |volume=8 |issue= 4 |pages= 426–39 |year= 2002 |pmid= 11991638 |doi=
*cite journal | author=Will CL, Urlaub H, Achsel T, "et al." |title=Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein. |journal=EMBO J. |volume=21 |issue= 18 |pages= 4978–88 |year= 2002 |pmid= 12234937 |doi=
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Grimwood J, Gordon LA, Olsen A, "et al." |title=The DNA sequence and biology of human chromosome 19. |journal=Nature |volume=428 |issue= 6982 |pages= 529–35 |year= 2004 |pmid= 15057824 |doi= 10.1038/nature02399
*cite journal | author=Takenaka K, Nakagawa H, Miyamoto S, Miki H |title=The pre-mRNA-splicing factor SF3a66 functions as a microtubule-binding and -bundling protein. |journal=Biochem. J. |volume=382 |issue= Pt 1 |pages= 223–30 |year= 2005 |pmid= 15142036 |doi= 10.1042/BJ20040521
*cite journal | author=Colland F, Jacq X, Trouplin V, "et al." |title=Functional proteomics mapping of a human signaling pathway. |journal=Genome Res. |volume=14 |issue= 7 |pages= 1324–32 |year= 2004 |pmid= 15231748 |doi= 10.1101/gr.2334104
*cite journal | author=Nesic D, Tanackovic G, Krämer A |title=A role for Cajal bodies in the final steps of U2 snRNP biogenesis. |journal=J. Cell. Sci. |volume=117 |issue= Pt 19 |pages= 4423–33 |year= 2005 |pmid= 15316075 |doi= 10.1242/jcs.01308

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