DDX46

DEAD (Asp-Glu-Ala-Asp) box polypeptide 46
Identifiers
Symbols	DDX46; FLJ25329; KIAA0801; MGC9936; PRPF5; Prp5
External IDs	MGI: 1920895 HomoloGene: 5430 GeneCards: DDX46 Gene
EC number	3.6.4.13
Gene Ontology Molecular function • nucleotide binding • RNA binding • helicase activity • ATP binding • ATP-dependent helicase activity • hydrolase activity Cellular component • nucleus • Cajal body • nuclear speck Biological process • mRNA processing • RNA splicing Sources: Amigo / QuickGO
RNA expression pattern
More reference expression data
Orthologs
Species	Human	Mouse
Entrez	9879	212880
Ensembl	ENSG00000145833	ENSMUSG00000021500
UniProt	Q7L014	Q05C73
RefSeq (mRNA)	NM_014829	NM_145975.3
RefSeq (protein)	NP_055644	NP_666087.3
Location (UCSC)	Chr 5: 134.09 – 134.19 Mb	Chr 13: 55.74 – 55.78 Mb
PubMed search	[1]	[2]

Probable ATP-dependent RNA helicase DDX46 is an enzyme that in humans is encoded by the DDX46 gene.^[1]

This gene encodes a member of the DEAD box protein family. DEAD box proteins, characterized by the conserved motif Asp-Glu-Ala-Asp (DEAD), are putative RNA helicases. They are implicated in a number of cellular processes involving alteration of RNA secondary structure, such as translation initiation, nuclear and mitochondrial splicing, and ribosome and spliceosome assembly. Based on their distribution patterns, some members of this family are believed to be involved in embryogenesis, spermatogenesis, and cellular growth and division. The protein encoded by this gene is a component of the 17S U2 snRNP complex; it plays an important role in pre-mRNA splicing.^[1]

Interactions

DDX46 has been shown to interact with SF3A2.^[2]

References

1. ^ ^{a b} "Entrez Gene: DDX46 DEAD (Asp-Glu-Ala-Asp) box polypeptide 46". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=9879. 
2. ^ Will, Cindy L; Urlaub Henning, Achsel Tilmann, Gentzel Marc, Wilm Matthias, Lührmann Reinhard (Sep. 2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein". EMBO J. (England) 21 (18): 4978–88. doi:10.1093/emboj/cdf480. ISSN 0261-4189. PMC 126279. PMID 12234937. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126279. 

Further reading

• Bonaldo MF, Lennon G, Soares MB (1997). "Normalization and subtraction: two approaches to facilitate gene discovery.". Genome Res. 6 (9): 791–806. doi:10.1101/gr.6.9.791. PMID 8889548. 
• Nagase T, Ishikawa K, Suyama M, et al. (1999). "Prediction of the coding sequences of unidentified human genes. XI. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro.". DNA Res. 5 (5): 277–86. doi:10.1093/dnares/5.5.277. PMID 9872452. 
• Will CL, Urlaub H, Achsel T, et al. (2002). "Characterization of novel SF3b and 17S U2 snRNP proteins, including a human Prp5p homologue and an SF3b DEAD-box protein.". EMBO J. 21 (18): 4978–88. doi:10.1093/emboj/cdf480. PMC 126279. PMID 12234937. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=126279. 
• Strausberg RL, Feingold EA, Grouse LH, et al. (2003). "Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences.". Proc. Natl. Acad. Sci. U.S.A. 99 (26): 16899–903. doi:10.1073/pnas.242603899. PMC 139241. PMID 12477932. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=139241. 
• Xu YZ, Newnham CM, Kameoka S, et al. (2004). "Prp5 bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA.". EMBO J. 23 (2): 376–85. doi:10.1038/sj.emboj.7600050. PMC 1271757. PMID 14713954. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=1271757. 
• Beausoleil SA, Jedrychowski M, Schwartz D, et al. (2004). "Large-scale characterization of HeLa cell nuclear phosphoproteins.". Proc. Natl. Acad. Sci. U.S.A. 101 (33): 12130–5. doi:10.1073/pnas.0404720101. PMC 514446. PMID 15302935. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=514446. 
• Gerhard DS, Wagner L, Feingold EA, et al. (2004). "The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC).". Genome Res. 14 (10B): 2121–7. doi:10.1101/gr.2596504. PMC 528928. PMID 15489334. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=528928. 
• Rual JF, Venkatesan K, Hao T, et al. (2005). "Towards a proteome-scale map of the human protein-protein interaction network.". Nature 437 (7062): 1173–8. doi:10.1038/nature04209. PMID 16189514. 
• Olsen JV, Blagoev B, Gnad F, et al. (2006). "Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.". Cell 127 (3): 635–48. doi:10.1016/j.cell.2006.09.026. PMID 17081983.