Small nucleolar RNA Z107/R87

Small nucleolar RNA RZ107/R87 refers to a group of related non-coding RNA (ncRNA) molecules which function in the biogenesis of other small nuclear RNAs (snRNAs). These small nucleolar RNAs (snoRNAs) are modifiying RNAs and usually located in the nucleolus of the eukaryotic cell which is a major site of snRNA biogenesis.

These two snoRNAs R87 and Z107 were identified in the plant "Arabidopsis thaliana" cite journal |author=Barneche F, Gaspin C, Guyot R, Echeverría M |title=Identification of 66 box C/D snoRNAs in Arabidopsis thaliana: extensive gene duplications generated multiple isoforms predicting new ribosomal RNA 2'-O-methylation sites |journal=J. Mol. Biol. |volume=311 |issue=1 |pages=57–73 |year=2001 |pmid=11469857 |doi=10.1006/jmbi.2001.4851 |issn=] and rice "Oryza sativa" cite journal |author=Chen CL, Liang D, Zhou H, Zhuo M, Chen YQ, Qu LH |title=The high diversity of snoRNAs in plants: identification and comparative study of 120 snoRNA genes from Oryza sativa |journal=Nucleic Acids Res. |volume=31 |issue=10 |pages=2601–13 |year=2003 |pmid=12736310 |doi= |issn=] respectively. These related snoRNAs are predicted to belong to the C/D box class of snoRNAs which contain the conserved sequence motifs known as the C box (UGAUGA) and the D box (CUGA). Most of the members of the box C/D family function in directing site-specific 2'-O-methylation of substrate RNAs [cite journal | last = Galardi | first = S | coauthors = Fatica A, Bachi A, Scaloni A, Presutti C, Bozzoni I | year = 2002 | title = Purified box C/D snoRNPs are able to reproduce site-specific 2'-O-methylation of target RNA in vitro | journal = Mol Cell Biol | volume = 22 | pages = 6663–6668 | pmid = 12215523 | doi = 10.1128/MCB.22.19.6663-6668.2002] .

References

External links

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* [http://bioinf.scri.sari.ac.uk/cgi-bin/plant_snorna/home plant snoRNA database]