Small Cajal body specific RNA 24
- Small Cajal body specific RNA 24
Small Cajal body specific RNA 24 (also known as scaRNA24 or ACA12) is a small nucleolar RNA found in Cajal bodies and believed to be involved in the pseudouridylation (isomerisation of uridine to pseudouridine) of U6 spliceosomal RNA.
scaRNAs are a specific class of small nucleolar RNAs that localise to the Cajal bodies and guide the modification of RNA polymerase II transcribed spliceosomal RNAs U1, U2, U4, U5 and U12.[cite journal | last = Darzacq | first = X | coauthors = Jady BE, Verheggen C, Kiss AM, Bertrand E, Kiss T | year = 2002 | title = Cajal body-specific small nuclear RNAs: a novel class of 2'-O-methylation and pseudouridylation guide RNAs | journal = EMBO J. | volume = 21 | pages = 2746–2756 | pmid = 12032087 | doi = 10.1093/emboj/21.11.2746] ]ACA12 belongs to the H/ACA box class of guide RNAs as it has the predicted hairpin-hinge-hairpin-tail structure,the conserved H/ACA-box motifs and is found associated with GAR1 protein [cite journal | author = Kiss AM, Jády BE, Bertrand E, Kiss T | title = Human box H/ACA pseudouridylation guide RNA machinery | journal = Mol. Cell. Biol. | volume = 24 | issue = 13 | pages = 5797–807 | year = 2004 | pmid = 15199136 | doi = 10.1128/MCB.24.13.5797-5807.2004 | issn = ] . ACA12 is predicted to guide the pseudouridylation of residue U40 of the spliceosomal U6 snRNA ][cite journal | last = Lestrade | first = L | coauthors = Weber MJ | year = 2006 | title = snoRNA-LBME-db, a comprehensive database of human H/ACA and C/D box snoRNAs | journal = Nucleic Acids Res. | volume = 34 | pages = D158–D162 | pmid = 16381836 | doi = 10.1093/nar/gkj002] . ]References
External links
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* [http://www-snorna.biotoul.fr/plus.php?id=ACA12 snoRNABase entry for SCARNA24]
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