Pseudouridine

Pseudouridine

Pseudouridine (abbreviated Ψ) is the C-glycoside isomer of the nucleoside uridine, and it is the most prevalent of the over one hundred different modified nucleosides found in
RNA. [cite journal |author=Hamma T, Ferré-D'Amaré AR |title=Pseudouridine synthases |journal=Chem. Biol. |volume=13 |issue=11 |pages=1125–35 |year=2006 |pmid=17113994 |doi=10.1016/j.chembiol.2006.09.009] Ψ is found in all species and in all classes of RNA including mRNA. [cite journal |author=Charette M, Gray MW |title=Pseudouridine in RNA: what, where, how, and why |journal=IUBMB Life |volume=49 |issue=5 |pages=341–51 |year=2000 |pmid=10902565 |doi=10.1080/152165400410182] [cite journal |author=Liang XH, Xu YX, MIchaeli S|title=The spliced leader-associated RNA is a trypanosome-specific sn(o) RNA that has the potential to guide pseudouridine formation on the SL RNA| journal=RNA|volume=8 |issue=2|pages=237–246 |year=2002 |pmid=11911368] Ψ is formed by enzymes called Ψ synthases, which post-transcriptionally isomerize specificuridine residues in RNA in a process termed "pseudouridylation". [cite journal |author=Ferré-D'Amaré AR |title=RNA-modifying enzymes |journal=Curr. Opin. Struct. Biol. |volume=13 |issue=1 |pages=49–55 |year=2003 |pmid=12581659 |doi=10.1016/S0959-440X(02)00002-7]

Recent studies suggest it may offer protection from radiation [cite journal|title= [http://cat.inist.fr/?aModele=afficheN&cpsidt=14885511 -Pseudouridine, a beer component, reduces radiation-induced chromosome aberrations in human lymphocytes] ]

References


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  • Pseudouridine — Structure de la pseudouridine Général Nom IUPAC 5 [(2S,3R,4S,5R) 3,4 dihydroxy 5 (hydroxyméthyl)oxolan 2 yl] 1H pyrimi …   Wikipédia en Français

  • pseudouridine — pseudouridine. См. псевдоуридин. (Источник: «Англо русский толковый словарь генетических терминов». Арефьев В.А., Лисовенко Л.А., Москва: Изд во ВНИРО, 1995 г.) …   Молекулярная биология и генетика. Толковый словарь.

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  • Pseudouridine kinase — In enzymology, a pseudouridine kinase (EC number|2.7.1.83) is an enzyme that catalyzes the chemical reaction:ATP + pseudouridine ightleftharpoons ADP + pseudouridine 5 phosphateThus, the two substrates of this enzyme are ATP and pseudouridine,… …   Wikipedia

  • pseudouridine excretion — increased excretion of pseudouridine in the urine of patients with gout; its significance remains to be established. A greater turnover of some forms of RNA has been suggested, possibly adding to the hyperuricemia of gout …   Medical dictionary

  • pseudouridine — (= 5 b D ribofuranosyluracil) Unusual nucleotide found in some tRNA: glycosidic bond is associated with position 5 of uracil, not position 1 …   Dictionary of molecular biology

  • pseudouridine — noun An isomer of uridine associated with RNA …   Wiktionary

  • pseudouridine — 5 β d Ribosyluracil; a naturally occurring isomer of uridine found in transfer ribonucleic acid s; unique in that the ribosyl is attached to carbon (C 5) rather than to nitrogen; excreted in urine. * * * pseu·do·uri·dine yu̇r ə .dēn n a… …   Medical dictionary

  • pseudouridine — pseu·do·uridine …   English syllables

  • pseudouridine — ˌ noun Etymology: International Scientific Vocabulary pseud + uridine : a nucleoside C9H12O6N2 that is a uracil derivative incorporated as a structural component into transfer RNA …   Useful english dictionary

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