Chlorproguanil hydrochloride-dapsone-artesunate

Chlorproguanil hydrochloride-dapsone-artesunate

Chlorproguanil-dapsone-artesunate (abbreviated CDA) is a new antimalarial treatment that entered Phase III clinical trials in 2006.

It consists of chlorproguanil hydrochloride, dapsone, and artesunate. (It can also be interpreted as Lapdap+artesunate).

It is being compared against artemether-lumefantrine (Coartem) and against chlorproguanil-dapsone Lapdap. This drug is being developed in collaboration between GlaxoSmithKline, UNICEF, the World Bank, Medicines for Malaria Venture and the WHO Special Programme for Research and Training in Tropical Diseases (WHO/TDR), the Liverpool School of Tropical Medicine, and the London School of Hygiene and Tropical Medicine.[1]

References

  1. ^ Das P (2006). "Promising anti-malarial enters phase II studies.". Lancet Infect Dis 6 (9): 551. doi:10.1016/S1473-3099(06)70571-0. 

External links

Individual
agents
Other
DHFR inhibitors
(antifols)
2,4-Diaminopyrimidines (pyrimethamine)
biguanides (proguanil# • chlorproguanil)
Sulfadoxine • sulfamethoxypyrazine
Coformulation
Fansidar# (sulfadoxine/pyrimethamine)
Other
Atovaquone (as Malarone)
Tetracycline • Doxycycline#
Clindamycin
Combi-
nations
Fixed-dose (coformulated) ACTs
artemether-lumefantrine#
artesunate-amodiaquine (ASAQ)
artesunate-mefloquine (ASMQ)
dihydroartemisinin-piperaquine
artesunate-pyronaridine
Other combinations
(not co-formulated)
artesunate/SP • artesunate/mefloquine •
quinine/tetracycline • quinine/doxycycline • quinine/clindamycin
Hetero-
kont

M: PRO

ambz, excv, chrm (strc)

ambz, excv, chrm

ambz, excv, chrm

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