- Duodenal cytochrome B
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cytochrome b reductase 1 Identifiers Symbol CYBRD1 Alt. symbols DCYTB Entrez 79901 HUGO 20797 OMIM 605745 RefSeq NM_024843 UniProt Q53TN4 Other data Locus Chr. 2 q31 Duodenal cytochrome B (Dcytb) has been identified as the reductase enzyme which catalyzes the reduction of Fe3+ to Fe2+ in the process of iron absorption in the duodenum of mammals.[1] According to research carried out, it appears that Dcytb upregulation is controlled by a number of independent stimulators or inhibitors of iron absorption. Furthermore, Dcytb has also been shown to exist in other tissues besides the apical region of the duodenum; and as such, it is believed to play a major role in iron metabolism in tissues.
References
- ^ Latunde-Dada GO, Van der Westhuizen J, Vulpe CD et al. (2002). "Molecular and functional roles of duodenal cytochrome B (Dcytb) in iron metabolism". Blood Cells Mol. Dis. 29 (3): 356–60. doi:10.1006/bcmd.2002.0574. PMID 12547225.
External links
Metabolism: Metal metabolism Transition metal Iron(II) oxide: DMT1 (SLC11A2) · Ferritin · Hephaestin/Ferroportin (SLC11A3/SLC40A1) · Transferrin to Transferrin receptor (TFRC, TFR2)
Iron(III) oxide: Duodenal cytochrome B · Integrin · Calreticulin/mobilferrin · FerritinOtherZinc metabolismElectrolyte Sodium metabolismPhosphate metabolismMagnesium metabolismM: NUT
cof, enz, met
noco, nuvi, sysi/epon, met
drug(A8/11/12)
Categories:- Genes on chromosome 2
- Physiology
- Enzymes
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