- ATOX1
ATX1 antioxidant protein 1 homolog (yeast), also known as ATOX1, is a human
gene .cite web | title = Entrez Gene: ATOX1 ATX1 antioxidant protein 1 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=475| accessdate = ]PBB_Summary
section_title =
summary_text = This gene encodes a copper chaperone that plays a role in copper homeostasis by binding and transporting cytosolic copper to ATPase proteins in the trans-Golgi network for later incorporation to the ceruloplasmin. This protein also functions as an antioxidant against superoxide and hydrogen peroxide, and therefore, may play a significant role in cancer carcinogenesis. Because of its cytogenetic location, this gene represents a candidate gene for 5q-syndrome.cite web | title = Entrez Gene: ATOX1 ATX1 antioxidant protein 1 homolog (yeast)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=475| accessdate = ]References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Klomp LW, Lin SJ, Yuan DS, "et al." |title=Identification and functional expression of HAH1, a novel human gene involved in copper homeostasis. |journal=J. Biol. Chem. |volume=272 |issue= 14 |pages= 9221–6 |year= 1997 |pmid= 9083055 |doi=
*cite journal | author=Hung IH, Casareno RL, Labesse G, "et al." |title=HAH1 is a copper-binding protein with distinct amino acid residues mediating copper homeostasis and antioxidant defense. |journal=J. Biol. Chem. |volume=273 |issue= 3 |pages= 1749–54 |year= 1998 |pmid= 9430722 |doi=
*cite journal | author=Larin D, Mekios C, Das K, "et al." |title=Characterization of the interaction between the Wilson and Menkes disease proteins and the cytoplasmic copper chaperone, HAH1p. |journal=J. Biol. Chem. |volume=274 |issue= 40 |pages= 28497–504 |year= 1999 |pmid= 10497213 |doi=
*cite journal | author=Hamza I, Schaefer M, Klomp LW, Gitlin JD |title=Interaction of the copper chaperone HAH1 with the Wilson disease protein is essential for copper homeostasis. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=96 |issue= 23 |pages= 13363–8 |year= 1999 |pmid= 10557326 |doi=
*cite journal | author=Wernimont AK, Huffman DL, Lamb AL, "et al." |title=Structural basis for copper transfer by the metallochaperone for the Menkes/Wilson disease proteins. |journal=Nat. Struct. Biol. |volume=7 |issue= 9 |pages= 766–71 |year= 2000 |pmid= 10966647 |doi= 10.1038/78999
*cite journal | author=Boultwood J, Strickson AJ, Jabs EW, "et al." |title=Physical mapping of the human ATX1 homologue (HAH1) to the critical region of the 5q- syndrome within 5q32, and immediately adjacent to the SPARC gene. |journal=Hum. Genet. |volume=106 |issue= 1 |pages= 127–9 |year= 2000 |pmid= 10982193 |doi=
*cite journal | author=Walker JM, Tsivkovskii R, Lutsenko S |title=Metallochaperone Atox1 transfers copper to the NH2-terminal domain of the Wilson's disease protein and regulates its catalytic activity. |journal=J. Biol. Chem. |volume=277 |issue= 31 |pages= 27953–9 |year= 2002 |pmid= 12029094 |doi= 10.1074/jbc.M203845200
*cite journal | author=Moore SD, Helmle KE, Prat LM, Cox DW |title=Tissue localization of the copper chaperone ATOX1 and its potential role in disease. |journal=Mamm. Genome |volume=13 |issue= 10 |pages= 563–8 |year= 2003 |pmid= 12420134 |doi= 10.1007/s00335-002-2172-9
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Liu PC, Koeller DM, Kaler SG |title=Genomic organization of ATOX1, a human copper chaperone. |journal=BMC Genet. |volume=4 |issue= |pages= 4 |year= 2004 |pmid= 12594858 |doi=
*cite journal | author=Strausak D, Howie MK, Firth SD, "et al." |title=Kinetic analysis of the interaction of the copper chaperone Atox1 with the metal binding sites of the Menkes protein. |journal=J. Biol. Chem. |volume=278 |issue= 23 |pages= 20821–7 |year= 2003 |pmid= 12679332 |doi= 10.1074/jbc.M212437200
*cite journal | author=Ralle M, Lutsenko S, Blackburn NJ |title=X-ray absorption spectroscopy of the copper chaperone HAH1 reveals a linear two-coordinate Cu(I) center capable of adduct formation with exogenous thiols and phosphines. |journal=J. Biol. Chem. |volume=278 |issue= 25 |pages= 23163–70 |year= 2003 |pmid= 12686548 |doi= 10.1074/jbc.M303474200
*cite journal | author=Lutsenko S, Tsivkovskii R, Walker JM |title=Functional properties of the human copper-transporting ATPase ATP7B (the Wilson's disease protein) and regulation by metallochaperone Atox1. |journal=Ann. N. Y. Acad. Sci. |volume=986 |issue= |pages= 204–11 |year= 2003 |pmid= 12763797 |doi=
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Wernimont AK, Yatsunyk LA, Rosenzweig AC |title=Binding of copper(I) by the Wilson disease protein and its copper chaperone. |journal=J. Biol. Chem. |volume=279 |issue= 13 |pages= 12269–76 |year= 2004 |pmid= 14709553 |doi= 10.1074/jbc.M311213200
*cite journal | author=Brandenberger R, Wei H, Zhang S, "et al." |title=Transcriptome characterization elucidates signaling networks that control human ES cell growth and differentiation. |journal=Nat. Biotechnol. |volume=22 |issue= 6 |pages= 707–16 |year= 2005 |pmid= 15146197 |doi= 10.1038/nbt971
*cite journal | author=Anastassopoulou I, Banci L, Bertini I, "et al." |title=Solution structure of the apo and copper(I)-loaded human metallochaperone HAH1. |journal=Biochemistry |volume=43 |issue= 41 |pages= 13046–53 |year= 2004 |pmid= 15476398 |doi= 10.1021/bi0487591
*cite journal | author=Gerhard DS, Wagner L, Feingold EA, "et al." |title=The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). |journal=Genome Res. |volume=14 |issue= 10B |pages= 2121–7 |year= 2004 |pmid= 15489334 |doi= 10.1101/gr.2596504
*cite journal | author=Banci L, Bertini I, Ciofi-Baffoni S, "et al." |title=An NMR study of the interaction between the human copper(I) chaperone and the second and fifth metal-binding domains of the Menkes protein. |journal=FEBS J. |volume=272 |issue= 3 |pages= 865–71 |year= 2005 |pmid= 15670166 |doi= 10.1111/j.1742-4658.2004.04526.x
*cite journal | author=Jeney V, Itoh S, Wendt M, "et al." |title=Role of antioxidant-1 in extracellular superoxide dismutase function and expression. |journal=Circ. Res. |volume=96 |issue= 7 |pages= 723–9 |year= 2005 |pmid= 15761197 |doi= 10.1161/01.RES.0000162001.57896.66PBB_Controls
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