- HAMP
Hepcidin antimicrobial peptide, also known as HAMP, is a human
gene .cite web | title = Entrez Gene: HAMP hepcidin antimicrobial peptide| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=57817| accessdate = ]The product encoded by this gene is involved in the maintenance of iron homeostasis, and it is necessary for the regulation of iron storage in
macrophage s, and for intestinal iron absorption. The preproprotein is post-translationally cleaved into mature peptides of 20, 22 and 25 amino acids, and these active peptides are rich in cysteines, which form intramolecular bonds that stabilize theirbeta sheet structures. These peptides exhibit antimicrobial activity. Mutations in this gene cause hemochromatosis type 2B, also known as juvenile hemochromatosis, a disease caused by severe iron overload that results incardiomyopathy ,cirrhosis , and endocrine failure.ee also
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Hepcidin References
Further reading
PBB_Further_reading
citations =
*cite journal | author=Ganz T |title=Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. |journal=Blood |volume=102 |issue= 3 |pages= 783–8 |year= 2003 |pmid= 12663437 |doi= 10.1182/blood-2003-03-0672
*cite journal | author=Roy CN, Andrews NC |title=Anemia of inflammation: the hepcidin link. |journal=Curr. Opin. Hematol. |volume=12 |issue= 2 |pages= 107–11 |year= 2005 |pmid= 15725899 |doi=
*cite journal | author=Fleming RE, Britton RS, Waheed A, "et al." |title=Pathophysiology of hereditary hemochromatosis. |journal=Semin. Liver Dis. |volume=25 |issue= 4 |pages= 411–9 |year= 2006 |pmid= 16315135 |doi= 10.1055/s-2005-923313
*cite journal | author=Krause A, Neitz S, Mägert HJ, "et al." |title=LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. |journal=FEBS Lett. |volume=480 |issue= 2-3 |pages= 147–50 |year= 2000 |pmid= 11034317 |doi=
*cite journal | author=Park CH, Valore EV, Waring AJ, Ganz T |title=Hepcidin, a urinary antimicrobial peptide synthesized in the liver. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 7806–10 |year= 2001 |pmid= 11113131 |doi= 10.1074/jbc.M008922200
*cite journal | author=Pigeon C, Ilyin G, Courselaud B, "et al." |title=A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is overexpressed during iron overload. |journal=J. Biol. Chem. |volume=276 |issue= 11 |pages= 7811–9 |year= 2001 |pmid= 11113132 |doi= 10.1074/jbc.M008923200
*cite journal | author=Majore S, Binni F, Ricerca BM, "et al." |title=Absence of hepcidin gene mutations in 10 Italian patients with primary iron overload. |journal=Haematologica |volume=87 |issue= 2 |pages= 221–2 |year= 2002 |pmid= 11836175 |doi=
*cite journal | author=Klüver E, Schulz A, Forssmann WG, Adermann K |title=Chemical synthesis of beta-defensins and LEAP-1/hepcidin. |journal=J. Pept. Res. |volume=59 |issue= 6 |pages= 241–8 |year= 2002 |pmid= 12010514 |doi=
*cite journal | author=Hunter HN, Fulton DB, Ganz T, Vogel HJ |title=The solution structure of human hepcidin, a peptide hormone with antimicrobial activity that is involved in iron uptake and hereditary hemochromatosis. |journal=J. Biol. Chem. |volume=277 |issue= 40 |pages= 37597–603 |year= 2002 |pmid= 12138110 |doi= 10.1074/jbc.M205305200
*cite journal | author=Weinstein DA, Roy CN, Fleming MD, "et al." |title=Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. |journal=Blood |volume=100 |issue= 10 |pages= 3776–81 |year= 2003 |pmid= 12393428 |doi= 10.1182/blood-2002-04-1260
*cite journal | author=Nemeth E, Valore EV, Territo M, "et al." |title=Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. |journal=Blood |volume=101 |issue= 7 |pages= 2461–3 |year= 2003 |pmid= 12433676 |doi= 10.1182/blood-2002-10-3235
*cite journal | author=Roetto A, Papanikolaou G, Politou M, "et al." |title=Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. |journal=Nat. Genet. |volume=33 |issue= 1 |pages= 21–2 |year= 2003 |pmid= 12469120 |doi= 10.1038/ng1053
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899–903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Gehrke SG, Kulaksiz H, Herrmann T, "et al." |title=Expression of hepcidin in hereditary hemochromatosis: evidence for a regulation in response to the serum transferrin saturation and to non-transferrin-bound iron. |journal=Blood |volume=102 |issue= 1 |pages= 371–6 |year= 2003 |pmid= 12637325 |doi= 10.1182/blood-2002-11-3610
*cite journal | author=Merryweather-Clarke AT, Cadet E, Bomford A, "et al." |title=Digenic inheritance of mutations in HAMP and HFE results in different types of haemochromatosis. |journal=Hum. Mol. Genet. |volume=12 |issue= 17 |pages= 2241–7 |year= 2004 |pmid= 12915468 |doi= 10.1093/hmg/ddg225
*cite journal | author=Clark HF, Gurney AL, Abaya E, "et al." |title=The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. |journal=Genome Res. |volume=13 |issue= 10 |pages= 2265–70 |year= 2003 |pmid= 12975309 |doi= 10.1101/gr.1293003
*cite journal | author=Roetto A, Daraio F, Porporato P, "et al." |title=Screening hepcidin for mutations in juvenile hemochromatosis: identification of a new mutation (C70R). |journal=Blood |volume=103 |issue= 6 |pages= 2407–9 |year= 2004 |pmid= 14630809 |doi= 10.1182/blood-2003-10-3390
*cite journal | author=Jacolot S, Le Gac G, Scotet V, "et al." |title=HAMP as a modifier gene that increases the phenotypic expression of the HFE pC282Y homozygous genotype. |journal=Blood |volume=103 |issue= 7 |pages= 2835–40 |year= 2004 |pmid= 14670915 |doi= 10.1182/blood-2003-10-3366
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40–5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285PBB_Controls
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