Mangostin

Mangostin
IUPAC name 3,6,8-Trihydroxy-2-methoxy-1,7- bis(3-methylbut-2-enyl)xanthen-9-one
Identifiers
CAS number	6147-11-1 Y
PubChem	5281650
ChEMBL	CHEMBL323197 N
Jmol-3D images	Image 1
SMILES CC(=CCC1=C(C=C2C(=C1O)C(=O)C3=C (C(=C(C=C3O2)O)OC)CC=C(C)C)O)C
Properties
Molecular formula	C24H26O6
Molar mass	410.45 g/mol
Exact mass	410.172939
Appearance	Yellow crystalline solid
Melting point	182 °C, 455 K, 360 °F
N (verify) (what is: Y/N?) Except where noted otherwise, data are given for materials in their standard state (at 25 °C, 100 kPa)
Infobox references

Mangostin is a natural xanthonoid, a type of organic compound isolated from various parts of the mangosteen tree (Garcinia mangostana). It is a yellow crystalline solid with a xanthone core structure. Mangostin and a variety of other xanthones from mangosteen have been investigated for biological properties including antioxidant, anti-bacterial, anti-inflammatory, and anticancer activities.^[1] In animal studies, mangostin has been found to be a central nervous system depressant which causes sedation, decreased motor activity, and ptosis.^[2]

The rind of partially ripe mangosteen fruit yields mangostin and also the related compound β-mangostin. The rind of fully ripe fruits contains the xanthonoids gartanin, 8-disoxygartanin and normangostin. A derivative of mangostin, mangostin-3,6-di-O-glucoside, is a central nervous system depressant and causes a rise in blood pressure.

References

1. ^ Jung H, Su B, Keller W, Mehta R, Kinghorn A (2006). "Antioxidant xanthones from the pericarp of Garcinia mangostana (Mangosteen)". J. Agric. Food Chem. 54 (6): 2077–82. doi:10.1021/jf052649z. PMID 16536578. 
2. ^ Shankaranarayan D, Gopalakrishnan C, Kameswaran L. (1979). "Pharmacological profile of mangostin and its derivatives". Arch Int Pharmacodyn Ther. 239 (2): 257–269. PMID 314790.