PAS domain

PAS fold
Crystallographic structure of the PAS domain of the bacterial oxygen sensor protein fixL.[1] The protein is depicted as a rainbow colored cartoon (N-terminus = blue, C-terminus = red while the heme ligand is shown as sticks (carbon = white, nitrogen = blue, oxygen = red, iron = orange).
Identifiers
Symbol	PAS
Pfam	PF00989
InterPro	IPR013767
SMART	PAS
PROSITE	PDOC50112
SCOP	2phy
Available protein structures: Pfam structures PDB RCSB PDB; PDBe PDBsum structure summary

The PAS domain is a protein domain contained in many signalling proteins where it functions as a signal sensor.^[2][3] PAS domains are found in a large number of organisms from bacteria to humans. The PAS domain was named after the three proteins in which it occurs:

• Per – period circadian protein
• Arnt – aryl hydrocarbon receptor nuclear translocator protein
• Sim – single-minded protein

Many PAS-domain proteins detect their signal by way of an associated cofactor such as heme.^[4] Proteins that contain a PAS domain include Hypoxia-inducible factors.

References

1. ^ PDB 1y28; Dunham CM, Dioum EM, Tuckerman JR, Gonzalez G, Scott WG, Gilles-Gonzalez MA (July 2003). "A distal arginine in oxygen-sensing heme-PAS domains is essential to ligand binding, signal transduction, and structure". Biochemistry 42 (25): 7701–8. doi:10.1021/bi0343370. PMID 12820879. 
2. ^ Ponting CP, Aravind L (November 1997). "PAS: a multifunctional domain family comes to light". Curr. Biol. 7 (11): R674–7. doi:10.1016/S0960-9822(06)00352-6. PMID 9382818. 
3. ^ Hefti MH, Françoijs KJ, de Vries SC, Dixon R, Vervoort J (March 2004). "The PAS fold. A redefinition of the PAS domain based upon structural prediction". Eur. J. Biochem. 271 (6): 1198–208. doi:10.1111/j.1432-1033.2004.04023.x. PMID 15009198. 
4. ^ Gilles-Gonzalez MA, Gonzalez G (February 2004). "Signal transduction by heme-containing PAS-domain proteins". J. Appl. Physiol. 96 (2): 774–83. doi:10.1152/japplphysiol.00941.2003. PMID 14715687.