Leucine-rich repeat

Pfam_box
Symbol = LRR_1
Name =

A leucine-rich repeat (LRR) is a protein structural motif that forms an α/β horseshoe fold. It is composed of repeating 20-30 amino acid stretches that are unusually rich in the hydrophobic amino acid leucine. Typically, each repeat unit has beta strand-turn-alpha helix structure, and the assembled domain, composed of many such repeats, has a horseshoe shape with an interior parallel beta sheet and an exterior array of helices. One face of the beta sheet and one side of the helix array are exposed to solvent and are therefore dominated by hydrophilic residues. The region between the helices and sheets is the protein's hydrophobic core and is tighly sterically packed with leucine residues.

Examples

Leucine-rich repeat motifs have been identified in a large number of functionally unrelated proteins. The best-known example is the ribonuclease inhibitor, but other proteins such as the tropomyosin regulator tropomodulin and the toll-like receptor also share the motif. In fact, the toll-like receptor possesses 10 successive LRR motifs which serve to bind antigen.

Although the canonical LRR protein contains approximately one helix for every beta strand, variants that form beta-alpha superhelix folds sometimes have long loops rather than helices linking successive beta strands.

ee also

*Leucine zipper

External links

* [http://scop.mrc-lmb.cam.ac.uk/scop/data/scop.b.d.bb.html SCOP LRR fold]
* [http://www.cathdb.info/cgi-bin/cath/GotoCath.pl?cath=3.80 CATH Alpha-beta horseshoe architecture]

References

* Branden C, Tooze J. (1999). "Introduction to Protein Structure" 2nd ed. Garland Publishing: New York, NY.

Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать курсовую

Look at other dictionaries:

leucine-rich repeat — (LRR) a type of short motif of a protein that has about 24 residues and 5 leucines, which makes a hydrophobic region that participates in protein protein interactions. See leucine rich repeat protein, under protein … Medical dictionary
leucine-rich repeat protein — any of numerous glycoproteins that contain leucine rich repeats. Called also LRR p … Medical dictionary
leucine-rich repeat — Short motif (around 24 residues) with 5 7 leucines generally at positions 2, 5, 7, 12, 21, 24. Forms an amphipathic region and is probably involved in protein protein interactions … Dictionary of molecular biology
Morn repeat containing 1 — Identifiers Symbols MORN1; FLJ13941 External IDs MGI … Wikipedia
LRR protein — leucine rich repeat p … Medical dictionary
LRRK2 — Leucine rich repeat kinase 2 Rendering based on PDB 2ZEJ … Wikipedia
LGR6 — Leucine rich repeat containing G protein coupled receptor 6, also known as LGR6, is a human gene.cite web | title = Entrez Gene: LGR6 leucine rich repeat containing G protein coupled receptor 6| url =… … Wikipedia
LRRFIP1 — Leucine rich repeat (in FLII) interacting protein 1, also known as LRRFIP1, is a human gene.cite web | title = Entrez Gene: LRRFIP1 leucine rich repeat (in FLII) interacting protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… … Wikipedia
LRRN2 — Leucine rich repeat neuronal 2, also known as LRRN2, is a human gene.cite web | title = Entrez Gene: LRRN2 leucine rich repeat neuronal 2| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=10446| accessdate =… … Wikipedia
LRRC4 — Leucine rich repeat containing 4, also known as LRRC4, is a human gene.cite web | title = Entrez Gene: LRRC4 leucine rich repeat containing 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene Cmd=ShowDetailView TermToSearch=64101|… … Wikipedia

Academic Dictionaries and Encyclopedias

Leucine-rich repeat

Look at other dictionaries:

Share the article and excerpts

Academic Dictionaries and Encyclopedias

Wikipedia

Leucine-rich repeat

Look at other dictionaries:

Share the article and excerpts

Direct link