FYVE domain

FYVE domain

Pfam_box
Symbol = FYVE
Name = FYVE zinc finger


width =200
caption =Early endosome antigen 1 (EEA1) dimer with lipids
Pfam= PF01363
InterPro= IPR000306
SMART=
PROSITE = PDOC50178
SCOP = 1vfy
TCDB =
OPM family= 62
OPM protein= 1vfy
PDB=PDB3|1dvpA:156-219 PDB3|1vfyA:168-230 PDB3|1jocB:1347-1411PDB3|1hyjA:1347-1411 PDB3|1hyiA:1347-1411 PDB3|1wfkA:2-59PDB3|1x4uA:349-411

FYVE zinc finger domain is named after four proteins that it has been found in: Fab1, YOTB/ZK632.12, Vac1, and EEA1.

The FYVE finger binds two zinc ions. The FYVE finger has eight potential zinc coordinating cysteine positions. Many members of this family also include two histidines in a motif R+HHC+XCG, where + represents a charged residue and X any residue. FYVE domains bind Phosphatidylinositol 3-phosphate.

The FYVE finger is structural similarity to RING domain and PHD finger.

Human proteins containing this domain

ANKFY1; EEA1; FGD1; FGD2; FGD3; FGD4; FGD5; FGD6;
FYCO1; HGS; MTMR3; MTMR4; PIP5K3; PLEKHF1; PLEKHF2; RUFY1;
RUFY2; WDF3; WDFY1; WDFY2; WDFY3; ZFYVE1; ZFYVE16; ZFYVE19;
ZFYVE20; ZFYVE21; ZFYVE26; ZFYVE27; ZFYVE28; ZFYVE9;

References

* [1] . Endosomal localization of the autoantigen EEA1 is mediated by a zinc-binding FYVE finger. Stenmark H, Aasland R, Toh BH, D'Arrigo A; J Biol Chem 1996;271:24048-24054. PMID|8798641
* [2] . FYVE fingers bind PtdIns(3)P. Gaullier JM, Simonsen A, D'Arrigo A, Bremnes B, Stenmark H, Aasland R; Nature 1998;394:432-433. PMID|9697764
* [3] . FYVE-finger proteins - effectors of an inositol lipid. Stenmark H, Aasland R; J Cell Sci 1999;112:4175-4183. PMID|10564636

External links

* [http://www.expasy.org/cgi-bin/nicedoc.pl?PDOC50178 Zinc finger FYVE/FYVE-related type] in PROSITE
* [http://pfam.sanger.ac.uk/family?entry=PF01363 FYVE domain in Pfam]
* - Orientations of FYVE/PHD zinc finger domains in membranes (OPM)


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