- LIM domain
'LIM domains' are
protein structural domain s, comprised of two contiguouszinc finger domains, separated by a two-amino acid residuehydrophobic linker.cite journal | author = Kadrmas JL, Beckerle MC | title = The LIM domain: from the cytoskeleton to the nucleus | journal = Nat. Rev. Mol. Cell Biol. | volume = 5 | issue = 11 | pages = 920–31 | year = 2004 | pmid = 15520811 | doi = 10.1038/nrm1499 | issn = ] They are named after their initial discovery in the proteins Lin11, Isl-1 & Mec-3.cite journal | author = Bach I | title = The LIM domain: regulation by association | journal = Mech. Dev. | volume = 91 | issue = 1-2 | pages = 5–17 | year = 2000 | pmid = 10704826 | doi = 10.1016/S0925-4773(99)00314-7 | issn = ] LIM-domain containing proteins have been shown to play roles in cytoskeletal organisation, organ development andoncogenesis . LIM-domains mediate that are critical to cellular processes.LIM domains have highly divergent sequences, apart from certain key residues. The sequence divergence allow a great many different binding sites to be grafted onto the same basic domain. The conserved residues are those involved in
zinc binding or thehydrophobic core of the protein. The sequence signature of LIM domains are as follows:[C] - [X] 2-4- [C] - [X] 13-19- [W] - [H] - [X] 2-4- [C] - [F] - [LVI] - [C] - [X] 2-4- [C] - [X] 13-20-C- [X] 2-4- [C]
LIM domains frequently occur in multiples, as seen in proteins such as TES, LMO4, and can also be attached to other domains in order to confer a binding or targeting function upon them, such as LIM-kinase.
References
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