Trypanosoma cruzi parasites
Scientific classification
Domain: Eukaryota
Kingdom: Excavata
Phylum: Euglenozoa
Class: Kinetoplastida


The kinetoplastids are a group of single-cell flagellate protozoa, including a number of parasites responsible for serious diseases in humans and other animals, as well as various forms found in soil and aquatic environments. They are members of the phylum Euglenozoa and their major distinguishing feature is the presence of a kinetoplast, a DNA-containing granule located within the single mitochondrion associated with the base of the cell's flagella (the basal body).

The kinetoplastids were first defined by Honigberg in 1961 as the flagellate order Kinetoplastida.[1] They are traditionally divided into the biflagellate Bodonidae and uniflagellate Trypanosomatidae; the former appears to be paraphyletic to the latter. One family of kinetoplastids, the trypanosomatids, is notable as it includes several genera which are exclusively parasitic. Bodo is a typical genus within kinetoplastida and including various common free-living species which feed on bacteria. Others include Cryptobia and the parasitic Leishmania.



Kinetoplastids are eukaryotic and possess normal eukaryotic organelles, for example the nucleus, mitochondrion, golgi apparatus and flagellum. Along with these universal structures kinetoplastids have several distinguishing morphological features such as the kinetoplast, sub-pellicular microtubule array and the paraflagellar rod.


The kinetoplast, after which the class is named, contains the mitochondrial genome and is a dense DNA containing granule within the cell's single mitochondrion. The structure is made up of a network of concatenated circular DNA molecules and their associated structural proteins along with DNA and RNA polymerases. The kinetoplast is found at the base of a cell's flagella and is associated to the flagellum basal body by a cytoskeletal structure.


The cytoskeleton of kinetoplastids is primarily made up of microtubules. These make a highly regular array, the sub-pellicular array, which run parallel just under the cell surface along the long axis of the cell. Other microtubules with more specialised roles, such as the rootlet microtubules, are also present. Kinetoplastids are capable of forming actin microfilaments but their role in the cytoskeleton is not clear. Other cytoskeletal structures include the specialised attachment between the flagellum and the kinetoplast.


All kinetoplastids possess at least one flagellum, species in the order trypanosomatida have one and bodonina have two. In kinetoplastids with two flagella most forms have a leading and trailing flagellum, the latter of which may or may not be attached to the side of the cell. The flagella are used for locomotion and attachment to surfaces. The base of the flagella are found in a specialised pocket structure which is also the location of the cytostome.

Life cycle

Kinetoplastids may be free-living or parasitic. The order trypanosomatida is notable as it includes many genera which are exclusively parasitic. Trypanosomatids may have simple life cycles in a single host or more complex ones which progress through multiple differentiation stages in two hosts. Dramatic morphological changes are possible between lifecycle stages. Diseases caused by members of the order trypanosomatida include sleeping sickness and Chagas disease, caused by species of Trypanosoma, and leishmaniasis, caused by species of Leishmania.


  1. ^ Honigberg, B. M. (1963). "A contribution to systematics of the non-pigmented flagellates.". In Ludvík, J., Lom, J., Vávra, J. (eds.). Progress in Protozoology: proceedings of the first International Congress on protozoology held at Prague. Academic Press. 

External links

Wikimedia Foundation. 2010.

Look at other dictionaries:

  • kinetoplastid — ki·neto·plas·tid kə .net ə plas tid, kī n any protozoan of the order Kinetoplastida called also protomonad kinetoplastid adj * * * ki·ne·to·plas·tid (kĭ ne″to plasґtid) pertaining or relating to protozoa of the order Kinetoplastida …   Medical dictionary

  • kinetoplastid — noun Any of a group of parasitic flagellate protozoa, of the class Kinetoplastida, responsible for several diseases in humans and animals …   Wiktionary

  • kinetoplastid — /kaɪnitoʊˈplæstəd/ (say kuyneetoh plastuhd) noun one of a group of flagellate protozoans with a characteristic kinetoplast, many of which are responsible for serious diseases in humans …   Australian-English dictionary

  • Редактирование РНК — Комплекс редактирования, эдитосома Редактирование РНК (англ. RNA editing)  молекулярно биологический процесс, в ходе которого информация, содержащаяся в молекуле РНК изменяется путём химической модификации оснований. В настоящее время… …   Википедия

  • Trypanosoma — Trypanosomen Trypanosoma cruzi Systematik ohne Rang: Excavata ohne Rang …   Deutsch Wikipedia

  • Trypanosomen — Trypanosoma cruzi Systematik ohne Rang: Excavata ohne Rang: Euglenozoa …   Deutsch Wikipedia

  • Leishmania — Taxobox color = khaki name = Leishmania image width = 240px image caption = Leishmania donovani in bone marrow cell. domain = Eukaryota unranked phylum = Excavata phylum = Euglenozoa classis = Kinetoplastida ordo = Trypanosomatida genus =… …   Wikipedia

  • Trypanosome — Taxobox color = khaki name = Trypanosomes image width = 300px image caption = Trypanosoma cruzi parasites domain = Eukaryota unranked phylum = Excavata phylum = Euglenozoa subphylum = Mastigophora classis = Kinetoplastea ordo = Trypanosomatida… …   Wikipedia

  • Trypanosomatida — Trypanosomen im Blutausstrich eines Patienten mit afrikanischer Trypanosomiasis Systematik Domäne: Eukaryoten (Eucaryota) …   Deutsch Wikipedia

  • Trypanosomatidae — Trypanosomatida Trypanosomen im Blutausstrich eines Patienten mit afrikanischer Trypanosomiasis Systematik Domäne …   Deutsch Wikipedia

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”