Phosphoenolpyruvate-protein phosphotransferase

Phosphoenolpyruvate-protein phosphotransferase

In enzymology, a phosphoenolpyruvate-protein phosphotransferase (EC number|2.7.3.9) is an enzyme that catalyzes the chemical reaction

:phosphoenolpyruvate + protein histidine ightleftharpoons pyruvate + protein Npi-phospho-L-histidine

Thus, the two substrates of this enzyme are phosphoenolpyruvate and protein histidine, whereas its two products are pyruvate and protein Npi-phospho-L-histidine.

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with a nitrogenous group as acceptor. The systematic name of this enzyme class is phosphoenolpyruvate:protein-L-histidine Npi-phosphotransferase. Other names in common use include phosphoenolpyruvate sugar phosphotransferase enzyme I, phosphopyruvate-protein factor phosphotransferase, phosphopyruvate-protein phosphotransferase, sugar-PEP phosphotransferase enzyme I, and phosphoenolpyruvate:protein-L-histidine N-pros-phosphotransferase. This enzyme participates in phosphotransferase system (pts).

tructural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1EZA, PDB link|1EZB, PDB link|1EZC, PDB link|1EZD, PDB link|1ZYM, PDB link|2EZA, PDB link|2EZB, PDB link|2EZC, PDB link|2HRO, PDB link|2HWG, PDB link|3EZA, PDB link|3EZB, and PDB link|3EZE.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|37278-17-4."

Gene Ontology (GO) codes


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