GTP diphosphokinase

In enzymology, a GTP diphosphokinase (EC number|2.7.6.5) is an enzyme that catalyzes the chemical reaction

:ATP + GTP $ightleftharpoons$ AMP + guanosine 3'-diphosphate 5'-triphosphate

Thus, the two substrates of this enzyme are ATP and GTP, whereas its two products are AMP and guanosine 3'-diphosphate 5'-triphosphate.

This enzyme belongs to the family of transferases, specifically those transferring two phosphorus-containing groups (diphosphotransferases). The systematic name of this enzyme class is ATP:GTP 3'-diphosphotransferase. Other names in common use include stringent factor, guanosine 3',5'-polyphosphate synthase, GTP pyrophosphokinase, ATP-GTP 3'-diphosphotransferase, guanosine 5',3'-polyphosphate synthetase, (p)ppGpp synthetase I, (p)ppGpp synthetase II, guanosine pentaphosphate synthetase, GPSI, and GPSII. This enzyme participates in purine metabolism.

tructural studies

As of late 2007, 4 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1E3H, PDB link|1E3P, PDB link|1VJ7, and PDB link|2BE3.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|63690-89-1."

Gene Ontology (GO) codes