Inositol-3-phosphate synthase

In enzymology, an inositol-3-phosphate synthase (EC number|5.5.1.4) is an enzyme that catalyzes the chemical reaction

:D-glucose 6-phosphate $ightleftharpoons$ 1D-myo-inositol 3-phosphate

Hence, this enzyme has one substrate, D-glucose 6-phosphate, and one product, 1D-myo-inositol 3-phosphate.

This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is 1D-myo-inositol-3-phosphate lyase (isomerizing). Other names in common use include myo-inositol-1-phosphate synthase, D-glucose 6-phosphate cycloaldolase, inositol 1-phosphate synthatase, glucose 6-phosphate cyclase, inositol 1-phosphate synthetase, glucose-6-phosphate inositol monophosphate cycloaldolase, glucocycloaldolase, and 1L-myo-inositol-1-phosphate lyase (isomerizing). This enzyme participates in streptomycin biosynthesis and inositol phosphate metabolism. It employs one cofactor, NAD+.

tructural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes PDB link|1GR0, PDB link|1JKF, PDB link|1JKI, PDB link|1LA2, PDB link|1P1F, PDB link|1P1H, PDB link|1P1I, PDB link|1P1J, PDB link|1P1K, PDB link|1RM0, PDB link|1VJP, and PDB link|1VKO.

References

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External links

::"The CAS registry number for this enzyme class is CAS registry|9032-95-5."

Gene Ontology (GO) codes