Hemoglobin, delta

PDB rendering based on 1a00.
Symbols HBD;
External IDs OMIM142000 MGI96021 HomoloGene73881 GeneCards: HBD Gene
Species Human Mouse
Entrez 3045 15129
Ensembl ENSG00000223609 ENSMUSG00000073940
UniProt P02042 P02088
RefSeq (mRNA) NM_000519 XM_973056
RefSeq (protein) NP_000510 XP_978150
Location (UCSC) Chr 11:
5.25 – 5.26 Mb
Chr 7:
110.96 – 110.96 Mb
PubMed search [1] [2]

Hemoglobin subunit delta is a protein that in humans is encoded by the HBD gene.[1]

The delta (HBD) and beta (HBB) genes are normally expressed in the adult: two alpha chains plus two beta chains constitute HbA, which in normal adult life comprises about 97% of the total hemoglobin. Two alpha chains plus two delta chains constitute HbA-2, which with HbF comprises the remaining 3% of adult hemoglobin. Five beta-like globin genes are found within a 45 kb cluster on chromosome 11 in the following order: 5'-epsilon--Ggamma--Agamma--delta--beta-3'. Mutations in the delta-globin gene are associated with beta-thalassemia.[2]

See also


  1. ^ Higgs DR, Vickers MA, Wilkie AO, Pretorius IM, Jarman AP, Weatherall DJ (May 1989). "A review of the molecular genetics of the human alpha-globin gene cluster". Blood 73 (5): 1081–104. PMID 2649166. 
  2. ^ "Entrez Gene: HBD hemoglobin, delta". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3045. 

Further reading

  • Schillirò G, Russo-Mancuso G, Dibenedetto SP, et al. (1992). "Six rare hemoglobin variants found in Sicily.". Hemoglobin 15 (5): 431–7. doi:10.3109/03630269108998862. PMID 1802885. 
  • Collins FS, Weissman SM (1985). "The molecular genetics of human hemoglobin.". Prog. Nucleic Acid Res. Mol. Biol. 31: 315–462. PMID 6397774. 
  • Giardina B, Messana I, Scatena R, Castagnola M (1995). "The multiple functions of hemoglobin.". Crit. Rev. Biochem. Mol. Biol. 30 (3): 165–96. doi:10.3109/10409239509085142. PMID 7555018. 
see also disorders of globin and globulin proteins

Wikimedia Foundation. 2010.

Игры ⚽ Нужно сделать НИР?

Look at other dictionaries:

  • HBD — Hamburg Blue Devils Stadt: Hamburg Gegründet: 1992 Cheftrainer: Maximilian von Garnier Liga (2009): Regionalliga Nord Größte Erfolge 1996, 1997, 1998 …   Deutsch Wikipedia

  • HBD — 1. noun Having two of the same allele at a locus, or base at a SNP, where both copies are from a single ancestor strand …   Wiktionary

  • HBD — Hot Box Detector (Medical) **** Has been drinking (Community » Law) …   Abbreviations dictionary

  • HBD — has been drinking; homozygous by descent; hydroxybutyric dehydrogenase; hypophosphatemic bone disease …   Medical dictionary

  • HbD — hemoglobin D …   Medical dictionary

  • HBD — Honeywell Brain Damage Krankheit, hervorgerufen durch die Benutzung von Multics (heutzutage ausgestorben ; ) …   Acronyms

  • Hbd. — Halbband EN half volume …   Abkürzungen und Akronyme in der deutschsprachigen Presse Gebrauchtwagen

  • HBD — Heparina a bajas dosis …   Diccionario de siglas médicas y otras abreviaturas

  • HBD — Honeywell Brain Damage Krankheit, hervorgerufen durch die Benutzung von Multics (heutzutage ausgestorben ; ) …   Acronyms von A bis Z

  • hbd — happy birthday …   Glossary of chat acronyms & text shorthand

Share the article and excerpts

Direct link
Do a right-click on the link above
and select “Copy Link”