N-methyl-L-amino-acid oxidase

N-methyl-L-amino-acid oxidase
N-methyl-L-amino-acid oxidase
Identifiers
EC number 1.5.3.2
CAS number 9029-23-6
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a N-methyl-L-amino-acid oxidase (EC 1.5.3.2) is an enzyme that catalyzes the chemical reaction

an N-methyl-L-amino acid + H2O + O2 \rightleftharpoons an L-amino acid + formaldehyde + H2O2

The 3 substrates of this enzyme are N-methyl-L-amino acid, H2O, and O2, whereas its 3 products are L-amino acid, formaldehyde, and H2O2.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating). Other names in common use include N-methylamino acid oxidase, and demethylase. It has 2 cofactors: FAD, and Flavoprotein.

References

  • Moritani M (1952). "Demethylase. IV. Kinetics and reaction mechanism". Hukuoka Acta Med. 43: 651–658. 
  • Moritani M (1952). "Demethylase. V. Specificity and its relation to amino acid oxidase". Hukuoka Acta Med. 43: 731–735. 
  • HIROHATA R; Tung, TC; Fujii, S; Mito, H; Izumiya, N; Kenmochi, K; Hirohata, R (1954). "Specificity of rabbit kidney demethylase". J. Biol. Chem. 209 (2): 485–92. PMID 13192101.