N-methyl-L-amino-acid oxidase

N-methyl-L-amino-acid oxidase
Identifiers
EC number	1.5.3.2
CAS number	9029-23-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / EGO
Search PMC articles PubMed articles

In enzymology, a N-methyl-L-amino-acid oxidase (EC 1.5.3.2) is an enzyme that catalyzes the chemical reaction

an N-methyl-L-amino acid + H₂O + O₂ $\rightleftharpoons$ an L-amino acid + formaldehyde + H₂O₂

The 3 substrates of this enzyme are N-methyl-L-amino acid, H₂O, and O₂, whereas its 3 products are L-amino acid, formaldehyde, and H₂O₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-NH group of donors with oxygen as acceptor. The systematic name of this enzyme class is N-methyl-L-amino-acid:oxygen oxidoreductase (demethylating). Other names in common use include N-methylamino acid oxidase, and demethylase. It has 2 cofactors: FAD, and Flavoprotein.

References

• Moritani M (1952). "Demethylase. IV. Kinetics and reaction mechanism". Hukuoka Acta Med. 43: 651–658. 
• Moritani M (1952). "Demethylase. V. Specificity and its relation to amino acid oxidase". Hukuoka Acta Med. 43: 731–735. 
• HIROHATA R; Tung, TC; Fujii, S; Mito, H; Izumiya, N; Kenmochi, K; Hirohata, R (1954). "Specificity of rabbit kidney demethylase". J. Biol. Chem. 209 (2): 485–92. PMID 13192101. 

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