Nitrous-oxide reductase

Nitrous-oxide reductase
nitrous oxide reductase
Identifiers
EC number 1.7.99.6
CAS number 55576-44-8
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a nitrous oxide reductase (EC 1.7.99.6) is an enzyme that catalyzes the chemical reaction

nitrous oxide + 2 reduced cytochome c \rightleftharpoons nitrogen + H2O + 2 cytochrome c

The three substrates of this enzyme are nitrous oxide and reduced cytochrome c; its three products are nitrogen, H2O, and oxidized cytochrome c. The reaction is only observed in the nitrogen-forming direction.

This enzyme belongs to the family of oxidoreductases, specifically those acting on nitrogenous compounds as electron acceptors. The systematic name of this enzyme class is nitrogen:acceptor oxidoreductase (N2O-forming). Other names in common use include nitrous oxide reductase, N2O reductase, and nitrogen:(acceptor) oxidoreductase (N2O-forming). This enzyme participates in nitrogen metabolism and catalyses the last step in dissimilatory nitrate reduction. It contains copper ions as cofactors in the form of a mixed valence dinuclear CuA centre at the site of electron entry and a tetranuclear CuZ centre at the active site.

Structural studies

As of late 2007, 3 structures have been solved for this class of enzymes, with PDB accession codes 1FWX, 2IWF, and 2IWK.

References

  • Coyle CL, Zumft WG, Kroneck PM, Korner H, Jakob W (1985). "Nitrous oxide reductase from denitrifying Pseudomonas perfectomarina. Purification and properties of a novel multicopper enzyme". Eur. J. Biochem. 153 (3): 459–67. doi:10.1111/j.1432-1033.1985.tb09324.x. PMID 3000778. 
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