- Nitric-oxide reductase
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nitric oxide reductase Identifiers EC number 1.7.99.7 CAS number 37256-43-2 Databases IntEnz IntEnz view BRENDA BRENDA entry ExPASy NiceZyme view KEGG KEGG entry MetaCyc metabolic pathway PRIAM profile PDB structures RCSB PDB PDBe PDBsum Gene Ontology AmiGO / EGO Search PMC articles PubMed articles In enzymology, a nitric-oxide reductase (EC 1.7.99.7) is an enzyme that catalyzes the chemical reaction
- 2 nitric oxide + electron donor
nitrous oxide + oxidized electron donor + H2O
The 2 substrates of this enzyme are nitric oxide and electron donor, whereas its three products are nitrous oxide, oxidized electron donor/acceptor, and H2O.
This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with other acceptors. The systematic name of this enzyme class is nitrous-oxide:acceptor oxidoreductase (NO-forming). Other names in common use include nitrogen oxide reductase, and nitrous-oxide:(acceptor) oxidoreductase (NO-forming). This enzyme participates in nitrogen metabolism and in the microbial defense against nitric oxide toxicity.
Structural studies
As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1EHE, 1F24, 1F25, 1F26, 1JFB, 1JFC, 1ULW, and 1XQD.
References
- Heiss B, Frunzke K, Zumft WG (1989). "Formation of the N-N bond from nitric oxide by a membrane-bound cytochrome bc complex of nitrate-respiring (denitrifying) Pseudomonas stutzeri". J. Bacteriol. 171 (6): 3288–97. PMC 210048. PMID 2542222. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=210048.
- Gardner AM, Helmick RA, Gardner PR (2002). "Flavorubredoxin, an inducible catalyst for nitric oxide reduction and detoxification in Escherichia coli". J. Biol. Chem. 277 (10): 8172–77. doi:10.1074/jbc.M110471200. PMID 11751865.
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