Nitric-oxide reductase

Nitric-oxide reductase
nitric oxide reductase
Identifiers
EC number 1.7.99.7
CAS number 37256-43-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a nitric-oxide reductase (EC 1.7.99.7) is an enzyme that catalyzes the chemical reaction

2 nitric oxide + electron donor \rightleftharpoons nitrous oxide + oxidized electron donor + H2O

The 2 substrates of this enzyme are nitric oxide and electron donor, whereas its three products are nitrous oxide, oxidized electron donor/acceptor, and H2O.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with other acceptors. The systematic name of this enzyme class is nitrous-oxide:acceptor oxidoreductase (NO-forming). Other names in common use include nitrogen oxide reductase, and nitrous-oxide:(acceptor) oxidoreductase (NO-forming). This enzyme participates in nitrogen metabolism and in the microbial defense against nitric oxide toxicity.

Structural studies

As of late 2007, 8 structures have been solved for this class of enzymes, with PDB accession codes 1EHE, 1F24, 1F25, 1F26, 1JFB, 1JFC, 1ULW, and 1XQD.

References