Nitroquinoline-N-oxide reductase

Nitroquinoline-N-oxide reductase
nitroquinoline-N-oxide reductase
Identifiers
EC number 1.7.1.9
CAS number 37256-35-2
Databases
IntEnz IntEnz view
BRENDA BRENDA entry
ExPASy NiceZyme view
KEGG KEGG entry
MetaCyc metabolic pathway
PRIAM profile
PDB structures RCSB PDB PDBe PDBsum
Gene Ontology AmiGO / EGO

In enzymology, a nitroquinoline-N-oxide reductase (EC 1.7.1.9) is an enzyme that catalyzes the chemical reaction

4-(hydroxyamino)quinoline N-oxide + 2 NAD(P)+ + H2O \rightleftharpoons 4-nitroquinoline N-oxide + 2 NAD(P)H + 2 H+

The 4 substrates of this enzyme are 4-hydroxyaminoquinoline N-oxide, NAD+, NADP+, and H2O, whereas its 4 products are 4-nitroquinoline N-oxide, NADH, NADPH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on other nitrogenous compounds as donors with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 4-(hydroxyamino)quinoline N-oxide:NADP+ oxidoreductase. Other names in common use include 4-nitroquinoline 1-oxide reductase, 4NQO reductase, and NAD(P)H2:4-nitroquinoline-N-oxide oxidoreductase.

References

  • Toriyama N (1965). "[Metabolism of quinoline derivatives. On the reducing enzyme of 4-nitroquinoline-N-oxide]". Nichidai Igaku Zasshi 24: 423–432. 
  • Stanley JS, York JL, Benson AM (1992). "Nitroreductases and glutathione transferases that act on 4-nitroquinoline 1-oxide and their differential induction by butylated hydroxyanisole in mice". Cancer. Res. 52 (1): 58–63. PMID 1370076. 
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