- Calmodulin 1
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Calmodulin 1 (phosphorylase kinase, delta) 
PDB rendering based on 1a29.Available structures PDB 1AJI, 1CDL, 1CLL, 1CTR, 1IWQ, 1J7O, 1J7P, 1K90, 1K93, 1L7Z, 1LVC, 1NKF, 1PK0, 1S26, 1SK6, 1SW8, 1WRZ, 1XFU, 1XFV, 1XFW, 1XFX, 1XFY, 1XFZ, 1Y6W, 1YR5, 1YRT, 1YRU, 1ZOT, 1ZUZ, 2BE6, 2F3Y, 2F3Z, 2HF5, 2I08, 2JZI, 2K0E, 2K0F, 2K0J, 2K61, 2KNE, 2KUG, 2KUH, 2R28, 2V01, 2V02, 2VAY, 2W73, 2WEL, 2X0G, 3BYA, 3DVE, 3DVJ, 3DVK, 3DVM, 3EWT, 3EWV, 3G43, 3HR4, 3O77, 3O78, 3OXQ Identifiers Symbols CALM1; CALM2; CALM3; CALML2; CAMI; DD132; PHKD; caM External IDs OMIM: 114180 MGI: 88251 HomoloGene: 111276 GeneCards: CALM1 Gene EC number 2.7.11.19 Gene Ontology Sources: Amigo / QuickGO Orthologs Species Human Mouse Entrez 801 640703 Ensembl ENSG00000198668 ENSMUSG00000001175 UniProt P62158 P62204 RefSeq (mRNA) NM_001166106.1 NM_009790 RefSeq (protein) NP_001159578.1 NP_033920 Location (UCSC) Chr 14:
90.86 – 90.87 MbChr 12:
101.44 – 101.45 MbPubMed search [1] [2] Calmodulin 1 is a protein that in humans is encoded by the CALM1 gene.[1]
Contents
Function
Calmodulin 1 is the archetype of the family of calcium-modulated (calmodulin) proteins of which nearly 20 members have been found. They are identified by their occurrence in the cytosol or on membranes facing the cytosol and by a high affinity for calcium. Calmodulin contains 148 amino acids and has 4 calcium-binding motifs. Its functions include roles in growth and the cell cycle as well as in signal transduction and the synthesis and release of neurotransmitters.[2]
Interactions
Calmodulin 1 has been shown to interact with AKAP9,[3] TRPV1,[4] Androgen receptor,[5] IQGAP1[6][7] and PPEF1.[8]
References
- ^ Wawrzynczak EJ, Perham RN (August 1984). "Isolation and nucleotide sequence of a cDNA encoding human calmodulin". Biochem. Int. 9 (2): 177–85. PMID 6385987.
- ^ "Entrez Gene: CALM1 calmodulin 1 (phosphorylase kinase, delta)". http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=801.
- ^ Takahashi, Mikiko; Yamagiwa Akiko, Nishimura Tamako, Mukai Hideyuki, Ono Yoshitaka (Sep. 2002). "Centrosomal Proteins CG-NAP and Kendrin Provide Microtubule Nucleation Sites by Anchoring γ-Tubulin Ring Complex". Mol. Biol. Cell (United States) 13 (9): 3235–45. doi:10.1091/mbc.E02-02-0112. ISSN 1059-1524. PMC 124155. PMID 12221128. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=124155.
- ^ Numazaki, Mitsuko; Tominaga Tomoko, Takeuchi Kumiko, Murayama Namie, Toyooka Hidenori, Tominaga Makoto (Jun. 2003). "Structural determinant of TRPV1 desensitization interacts with calmodulin". Proc. Natl. Acad. Sci. U.S.A. (United States) 100 (13): 8002–6. doi:10.1073/pnas.1337252100. ISSN 0027-8424. PMC 164702. PMID 12808128. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=164702.
- ^ Cifuentes, Eugenia; Mataraza Jennifer M, Yoshida Barbara A, Menon Mani, Sacks David B, Barrack Evelyn R, Reddy G Prem-Veer (Jan. 2004). "Physical and functional interaction of androgen receptor with calmodulin in prostate cancer cells". Proc. Natl. Acad. Sci. U.S.A. (United States) 101 (2): 464–9. doi:10.1073/pnas.0307161101. ISSN 0027-8424. PMC 327170. PMID 14695896. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=327170.
- ^ Li, Zhigang; Sacks David B (Feb. 2003). "Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1". J. Biol. Chem. (United States) 278 (6): 4347–52. doi:10.1074/jbc.M208579200. ISSN 0021-9258. PMID 12446675.
- ^ Briggs, Michael W; Li Zhigang, Sacks David B (Mar. 2002). "IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin". J. Biol. Chem. (United States) 277 (9): 7453–65. doi:10.1074/jbc.M104315200. ISSN 0021-9258. PMID 11734550.
- ^ Kutuzov, Mikhail A; Solov'eva Olga V, Andreeva Alexandra V, Bennett Nelly (May. 2002). "Protein Ser/Thr phosphatases PPEF interact with calmodulin". Biochem. Biophys. Res. Commun. (United States) 293 (3): 1047–52. doi:10.1016/S0006-291X(02)00338-8. ISSN 0006-291X. PMID 12051765.
Further reading
- Zhang M, Yuan T (1999). "Molecular mechanisms of calmodulin's functional versatility". Biochem. Cell Biol. 76 (2–3): 313–23. doi:10.1139/bcb-76-2-3-313. PMID 9923700.
- Gusev NB (2002). "Some properties of caldesmon and calponin and the participation of these proteins in regulation of smooth muscle contraction and cytoskeleton formation". Biochemistry Mosc. 66 (10): 1112–21. doi:10.1023/A:1012480829618. PMID 11736632.
- Benaim G, Villalobo A (2002). "Phosphorylation of calmodulin. Functional implications". Eur. J. Biochem. 269 (15): 3619–31. doi:10.1046/j.1432-1033.2002.03038.x. PMID 12153558.
- Trudeau MC, Zagotta WN (2003). "Calcium/calmodulin modulation of olfactory and rod cyclic nucleotide-gated ion channels". J. Biol. Chem. 278 (21): 18705–8. doi:10.1074/jbc.R300001200. PMID 12626507.
PDB gallery 
1a29: CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:2 COMPLEX)
1ahr: CALMODULIN MUTANT WITH A TWO RESIDUE DELETION IN THE CENTRAL HELIX
1ak8: NMR SOLUTION STRUCTURE OF CERIUM-LOADED CALMODULIN AMINO-TERMINAL DOMAIN (CE2-TR1C), 23 STRUCTURES
1cdl: TARGET ENZYME RECOGNITION BY CALMODULIN: 2.4 ANGSTROMS STRUCTURE OF A CALMODULIN-PEPTIDE COMPLEX
1cdm: MODULATION OF CALMODULIN PLASTICITY IN MOLECULAR RECOGNITION ON THE BASIS OF X-RAY STRUCTURES
1cfc: CALCIUM-FREE CALMODULIN
1cfd: CALCIUM-FREE CALMODULIN
1cff: NMR SOLUTION STRUCTURE OF A COMPLEX OF CALMODULIN WITH A BINDING PEPTIDE OF THE CA2+-PUMP
1ckk: CALMODULIN/RAT CA2+/CALMODULIN DEPENDENT PROTEIN KINASE FRAGMENT
1cll: CALMODULIN STRUCTURE REFINED AT 1.7 ANGSTROMS RESOLUTION
1cm1: MOTIONS OF CALMODULIN-SINGLE-CONFORMER REFINEMENT
1cm4: MOTIONS OF CALMODULIN-FOUR-CONFORMER REFINEMENT
1cmf: NMR SOLUTION STRUCTURE OF APO CALMODULIN CARBOXY-TERMINAL DOMAIN
1cmg: NMR SOLUTION STRUCTURE OF CALCIUM-LOADED CALMODULIN CARBOXY-TERMINAL DOMAIN
1ctr: DRUG BINDING BY CALMODULIN: CRYSTAL STRUCTURE OF A CALMODULIN-TRIFLUOPERAZINE COMPLEX
1deg: THE LINKER OF DES-GLU84 CALMODULIN IS BENT AS SEEN IN THE CRYSTAL STRUCTURE
1dmo: CALMODULIN, NMR, 30 STRUCTURES
1f70: REFINED SOLUTION STRUCTURE OF CALMODULIN N-TERMINAL DOMAIN
1f71: REFINED SOLUTION STRUCTURE OF CALMODULIN C-TERMINAL DOMAIN
1fw4: CRYSTAL STRUCTURE OF E. COLI FRAGMENT TR2C FROM CALMODULIN TO 1.7 A RESOLUTION
1g4y: 1.60 A CRYSTAL STRUCTURE OF THE GATING DOMAIN FROM SMALL CONDUCTANCE POTASSIUM CHANNEL COMPLEXED WITH CALCIUM-CALMODULIN
1iq5: Calmodulin/nematode CA2+/Calmodulin dependent kinase kinase fragment
1iwq: Crystal Structure of MARCKS calmodulin binding domain peptide complexed with Ca2+/Calmodulin
1j7o: Solution structure of Calcium-calmodulin N-terminal domain
1j7p: Solution structure of Calcium calmodulin C-terminal domain
1k90: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
1k93: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin
1l7z: Crystal structure of Ca2+/Calmodulin complexed with myristoylated CAP-23/NAP-22 peptide
1lin: CALMODULIN COMPLEXED WITH TRIFLUOPERAZINE (1:4 COMPLEX)
1lvc: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin and 2' deoxy, 3' anthraniloyl ATP
1mux: SOLUTION NMR STRUCTURE OF CALMODULIN/W-7 COMPLEX: THE BASIS OF DIVERSITY IN MOLECULAR RECOGNITION, 30 STRUCTURES
1mxe: Structure of the Complex of Calmodulin with the Target Sequence of CaMKI
1niw: Crystal structure of endothelial nitric oxide synthase peptide bound to calmodulin
1nwd: Solution Structure of Ca2+/Calmodulin bound to the C-terminal Domain of Petunia Glutamate Decarboxylase
1ooj: Structural genomics of Caenorhabditis elegans : Calmodulin
1pk0: Crystal Structure of the EF3-CaM complexed with PMEApp
1prw: Crystal structure of bovine brain Ca++ calmodulin in a compact form
1qiv: CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD), 1:2 COMPLEX
1qiw: CALMODULIN COMPLEXED WITH N-(3,3,-DIPHENYLPROPYL)-N'-[1-R-(3,4-BIS-BUTOXYPHENYL)-ETHYL]-PROPYLENEDIAMINE (DPD)
1qs7: The 1.8 angstrom structure of calmodulin rs20 peptide complex
1qtx: THE 1.65 ANGSTROM STRUCTURE OF CALMODULIN RS20 PEPTIDE COMPLEX
1qx5: Crystal structure of apoCalmodulin
1qx7: Crystal structure of apoCaM bound to the gating domain of small conductance Ca2+-activated potassium channel
1s26: Structure of Anthrax Edema Factor-Calmodulin-alpha,beta-methyleneadenosine 5'-triphosphate Complex Reveals an Alternative Mode of ATP Binding to the Catalytic Site
1sk6: Crystal structure of the adenylyl cyclase domain of anthrax edema factor (EF) in complex with calmodulin, 3',5' cyclic AMP (cAMP), and pyrophosphate
1sw8: Solution structure of the N-terminal domain of Human N60D calmodulin refined with paramagnetism based strategy
1sy9: Structure of calmodulin complexed with a fragment of the olfactory CNG channel
1up5: CHICKEN CALMODULIN
1vrk: THE 1.9 ANGSTROM STRUCTURE OF E84K-CALMODULIN RS20 PEPTIDE COMPLEX
1wrz: Calmodulin complexed with a peptide from a human death-associated protein kinase
1x02: Solution structure of stereo array isotope labeled (SAIL) calmodulin
1xa5: Structure of Calmodulin in complex with KAR-2, a bis-indol alkaloid
1xfu: Crystal structure of anthrax edema factor (EF) truncation mutant, EF-delta 64 in complex with calmodulin
1xfv: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3' deoxy-ATP
1xfw: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and 3'5' cyclic AMP (cAMP)
1xfx: Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 10 millimolar exogenously added calcium chloride
1xfy: Crystal structure of anthrax edema factor (EF) in complex with calmodulin
1xfz: Crystal structure of anthrax edema factor (EF) in complex with calmodulin in the presence of 1 millimolar exogenously added calcium chloride
1y0v: Crystal structure of anthrax edema factor (EF) in complex with calmodulin and pyrophosphate
1y6w: Trapped intermediate of calmodulin
1yr5: 1.7-A structure of calmodulin bound to a peptide from DAP kinase
1yrt: Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin
1yru: Crystal Structure analysis of the adenylyl cyclaes catalytic domain of adenylyl cyclase toxin of Bordetella pertussis in presence of c-terminal calmodulin and 1mM calcium chloride
1zot: crystal structure analysis of the CyaA/C-Cam with PMEAPP
1zuz: Calmodulin in complex with a mutant peptide from human DRP-1 kinase
2bbm: SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR
2bbn: SOLUTION STRUCTURE OF A CALMODULIN-TARGET PEPTIDE COMPLEX BY MULTIDIMENSIONAL NMR
2bcx: Crystal structure of calmodulin in complex with a ryanodine receptor peptide
2be6: 2.0 A crystal structure of the CaV1.2 IQ domain-Ca/CaM complex
2bkh: MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2) CRYSTAL STRUCTURE
2bki: MYOSIN VI NUCLEOTIDE-FREE (MDINSERT2-IQ) CRYSTAL STRUCTURE
2col: Crystal structure analysis of CyaA/C-Cam with Pyrophosphate
2dfs: 3-D structure of Myosin-V inhibited state
2f2o: Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
2f2p: Structure of calmodulin bound to a calcineurin peptide: a new way of making an old binding mode
2f3y: Calmodulin/IQ domain complex
2f3z: Calmodulin/IQ-AA domain complex
2fot: Crystal structure of the complex between calmodulin and alphaII-spectrin
2hf5: The structure and function of a novel two-site calcium-binding fragment of calmodulin
2ix7: STRUCTURE OF APO-CALMODULIN BOUND TO UNCONVENTIONAL MYOSIN V
3cln: STRUCTURE OF CALMODULIN REFINED AT 2.2 ANGSTROMS RESOLUTION
4cln: STRUCTURE OF A RECOMBINANT CALMODULIN FROM DROSOPHILA MELANOGASTER REFINED AT 2.2-ANGSTROMS RESOLUTIONExternal links
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