IQGAP1

IQ motif containing GTPase activating protein 1, also known as IQGAP1, is a human gene.cite web | title = Entrez Gene: IQGAP1 IQ motif containing GTPase activating protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8826| accessdate = ]

PBB_Summary
section_title =
summary_text = This gene encodes a member of the IQGAP family. The protein contains four IQ domains, one calponin homology domain, one Ras-GAP domain and one WW domain. It interacts with components of the cytoskeleton, with cell adhesion molecules, and with several signaling molecules to regulate cell morphology and motility. Expression of the protein is upregulated by gene amplification in two gastric cancer cell lines.cite web | title = Entrez Gene: IQGAP1 IQ motif containing GTPase activating protein 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=8826| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Tirnauer JS |title=A new cytoskeletal connection for APC: linked to actin through IQGAP. |journal=Dev. Cell |volume=7 |issue= 6 |pages= 778–80 |year= 2005 |pmid= 15572120 |doi= 10.1016/j.devcel.2004.11.012
*cite journal | author=Nomura N, Nagase T, Miyajima N, "et al." |title=Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1. |journal=DNA Res. |volume=1 |issue= 5 |pages= 223–9 |year= 1995 |pmid= 7584044 |doi=
*cite journal | author=Weissbach L, Settleman J, Kalady MF, "et al." |title=Identification of a human rasGAP-related protein containing calmodulin-binding motifs. |journal=J. Biol. Chem. |volume=269 |issue= 32 |pages= 20517–21 |year= 1994 |pmid= 8051149 |doi=
*cite journal | author=Hart MJ, Callow MG, Souza B, Polakis P |title=IQGAP1, a calmodulin-binding protein with a rasGAP-related domain, is a potential effector for cdc42Hs. |journal=EMBO J. |volume=15 |issue= 12 |pages= 2997–3005 |year= 1996 |pmid= 8670801 |doi=
*cite journal | author=McCallum SJ, Wu WJ, Cerione RA |title=Identification of a putative effector for Cdc42Hs with high sequence similarity to the RasGAP-related protein IQGAP1 and a Cdc42Hs binding partner with similarity to IQGAP2. |journal=J. Biol. Chem. |volume=271 |issue= 36 |pages= 21732–7 |year= 1996 |pmid= 8702968 |doi=
*cite journal | author=Brill S, Li S, Lyman CW, "et al." |title=The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. |journal=Mol. Cell. Biol. |volume=16 |issue= 9 |pages= 4869–78 |year= 1996 |pmid= 8756646 |doi=
*cite journal | author=Kuroda S, Fukata M, Kobayashi K, "et al." |title=Identification of IQGAP as a putative target for the small GTPases, Cdc42 and Rac1. |journal=J. Biol. Chem. |volume=271 |issue= 38 |pages= 23363–7 |year= 1996 |pmid= 8798539 |doi=
*cite journal | author=Joyal JL, Annan RS, Ho YD, "et al." |title=Calmodulin modulates the interaction between IQGAP1 and Cdc42. Identification of IQGAP1 by nanoelectrospray tandem mass spectrometry. |journal=J. Biol. Chem. |volume=272 |issue= 24 |pages= 15419–25 |year= 1997 |pmid= 9182573 |doi=
*cite journal | author=Bashour AM, Fullerton AT, Hart MJ, Bloom GS |title=IQGAP1, a Rac- and Cdc42-binding protein, directly binds and cross-links microfilaments. |journal=J. Cell Biol. |volume=137 |issue= 7 |pages= 1555–66 |year= 1997 |pmid= 9199170 |doi=
*cite journal | author=McCallum SJ, Erickson JW, Cerione RA |title=Characterization of the association of the actin-binding protein, IQGAP, and activated Cdc42 with Golgi membranes. |journal=J. Biol. Chem. |volume=273 |issue= 35 |pages= 22537–44 |year= 1998 |pmid= 9712880 |doi=
*cite journal | author=Li Z, Kim SH, Higgins JM, "et al." |title=IQGAP1 and calmodulin modulate E-cadherin function. |journal=J. Biol. Chem. |volume=274 |issue= 53 |pages= 37885–92 |year= 2000 |pmid= 10608854 |doi=
*cite journal | author=Berryman M, Bretscher A |title=Identification of a novel member of the chloride intracellular channel gene family (CLIC5) that associates with the actin cytoskeleton of placental microvilli. |journal=Mol. Biol. Cell |volume=11 |issue= 5 |pages= 1509–21 |year= 2000 |pmid= 10793131 |doi=
*cite journal | author=Sugimoto N, Imoto I, Fukuda Y, "et al." |title=IQGAP1, a negative regulator of cell-cell adhesion, is upregulated by gene amplification at 15q26 in gastric cancer cell lines HSC39 and 40A. |journal=J. Hum. Genet. |volume=46 |issue= 1 |pages= 21–5 |year= 2001 |pmid= 11289714 |doi=
*cite journal | author=Briggs MW, Li Z, Sacks DB |title=IQGAP1-mediated stimulation of transcriptional co-activation by beta-catenin is modulated by calmodulin. |journal=J. Biol. Chem. |volume=277 |issue= 9 |pages= 7453–65 |year= 2002 |pmid= 11734550 |doi= 10.1074/jbc.M104315200
*cite journal | author=Nabeshima K, Shimao Y, Inoue T, Koono M |title=Immunohistochemical analysis of IQGAP1 expression in human colorectal carcinomas: its overexpression in carcinomas and association with invasion fronts. |journal=Cancer Lett. |volume=176 |issue= 1 |pages= 101–9 |year= 2002 |pmid= 11790459 |doi=
*cite journal | author=Mateer SC, McDaniel AE, Nicolas V, "et al." |title=The mechanism for regulation of the F-actin binding activity of IQGAP1 by calcium/calmodulin. |journal=J. Biol. Chem. |volume=277 |issue= 14 |pages= 12324–33 |year= 2002 |pmid= 11809768 |doi= 10.1074/jbc.M109535200
*cite journal | author=Swart-Mataraza JM, Li Z, Sacks DB |title=IQGAP1 is a component of Cdc42 signaling to the cytoskeleton. |journal=J. Biol. Chem. |volume=277 |issue= 27 |pages= 24753–63 |year= 2002 |pmid= 11948177 |doi= 10.1074/jbc.M111165200
*cite journal | author=Fukata M, Watanabe T, Noritake J, "et al." |title=Rac1 and Cdc42 capture microtubules through IQGAP1 and CLIP-170. |journal=Cell |volume=109 |issue= 7 |pages= 873–85 |year= 2002 |pmid= 12110184 |doi=
*cite journal | author=Mbele GO, Deloulme JC, Gentil BJ, "et al." |title=The zinc- and calcium-binding S100B interacts and co-localizes with IQGAP1 during dynamic rearrangement of cell membranes. |journal=J. Biol. Chem. |volume=277 |issue= 51 |pages= 49998–50007 |year= 2003 |pmid= 12377780 |doi= 10.1074/jbc.M205363200
*cite journal | author=Li Z, Sacks DB |title=Elucidation of the interaction of calmodulin with the IQ motifs of IQGAP1. |journal=J. Biol. Chem. |volume=278 |issue= 6 |pages= 4347–52 |year= 2003 |pmid= 12446675 |doi= 10.1074/jbc.M208579200

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