ARHGEF4

Rho guanine nucleotide exchange factor (GEF) 4, also known as ARHGEF4, is a human gene.cite web | title = Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50649| accessdate = ]

PBB_Summary
section_title =
summary_text = Rho GTPases play a fundamental role in numerous cellular processes that are initiated by extracellular stimuli that work through G protein coupled receptors. The encoded protein may form complex with G proteins and stimulate Rho-dependent signals. This protein is similar to rat collybistin protein. Alternative splicing of this gene generates two transcript variants which encode different isoforms. Also there is possibility for the usage of multiple polyadenylation sites for this gene.cite web | title = Entrez Gene: ARHGEF4 Rho guanine nucleotide exchange factor (GEF) 4| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50649| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Nakajima D, Okazaki N, Yamakawa H, "et al." |title=Construction of expression-ready cDNA clones for KIAA genes: manual curation of 330 KIAA cDNA clones. |journal=DNA Res. |volume=9 |issue= 3 |pages= 99-106 |year= 2003 |pmid= 12168954 |doi=
*cite journal | author=Kuraguchi M, Wang XP, Bronson RT, "et al." |title=Adenomatous polyposis coli (APC) is required for normal development of skin and thymus. |journal=PLoS Genet. |volume=2 |issue= 9 |pages= e146 |year= 2006 |pmid= 17002498 |doi= 10.1371/journal.pgen.0020146
*cite journal | author=Watanabe T, Wang S, Noritake J, "et al." |title=Interaction with IQGAP1 links APC to Rac1, Cdc42, and actin filaments during cell polarization and migration. |journal=Dev. Cell |volume=7 |issue= 6 |pages= 871-83 |year= 2005 |pmid= 15572129 |doi= 10.1016/j.devcel.2004.10.017
*cite journal | author=Kawasaki Y, Sato R, Akiyama T |title=Mutated APC and Asef are involved in the migration of colorectal tumour cells. |journal=Nat. Cell Biol. |volume=5 |issue= 3 |pages= 211-5 |year= 2003 |pmid= 12598901 |doi= 10.1038/ncb937
*cite journal | author=Strausberg RL, Feingold EA, Grouse LH, "et al." |title=Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. |journal=Proc. Natl. Acad. Sci. U.S.A. |volume=99 |issue= 26 |pages= 16899-903 |year= 2003 |pmid= 12477932 |doi= 10.1073/pnas.242603899
*cite journal | author=Kawasaki Y, Senda T, Ishidate T, "et al." |title=Asef, a link between the tumor suppressor APC and G-protein signaling. |journal=Science |volume=289 |issue= 5482 |pages= 1194-7 |year= 2000 |pmid= 10947987 |doi=
*cite journal | author=Thiesen S, Kübart S, Ropers HH, Nothwang HG |title=Isolation of two novel human RhoGEFs, ARHGEF3 and ARHGEF4, in 3p13-21 and 2q22. |journal=Biochem. Biophys. Res. Commun. |volume=273 |issue= 1 |pages= 364-9 |year= 2000 |pmid= 10873612 |doi= 10.1006/bbrc.2000.2925
*cite journal | author=Kikuno R, Nagase T, Ishikawa K, "et al." |title=Prediction of the coding sequences of unidentified human genes. XIV. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. |journal=DNA Res. |volume=6 |issue= 3 |pages= 197-205 |year= 1999 |pmid= 10470851 |doi=

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = yes
update_citations = yes