RDH8

RDH8

Retinol dehydrogenase 8 (all-trans), also known as RDH8, is a human gene.cite web | title = Entrez Gene: RDH8 retinol dehydrogenase 8 (all-trans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50700| accessdate = ]

PBB_Summary
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summary_text = All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH (Rattner et al., 2000). It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of photoreceptors; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin (Rando, 2001). This is a rate-limiting step in the visual cycle (Saari et al., 1998). [supplied by OMIM] cite web | title = Entrez Gene: RDH8 retinol dehydrogenase 8 (all-trans)| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=50700| accessdate = ]

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Rando RR |title=The biochemistry of the visual cycle. |journal=Chem. Rev. |volume=101 |issue= 7 |pages= 1881-96 |year= 2001 |pmid= 11710234 |doi=
*cite journal | author=Maeda A, Maeda T, Imanishi Y, "et al." |title=Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo. |journal=J. Biol. Chem. |volume=280 |issue= 19 |pages= 18822-32 |year= 2005 |pmid= 15755727 |doi= 10.1074/jbc.M501757200
*cite journal | author=Perrault I, Hanein S, Gerber S, "et al." |title=Retinal dehydrogenase 12 (RDH12) mutations in leber congenital amaurosis. |journal=Am. J. Hum. Genet. |volume=75 |issue= 4 |pages= 639-46 |year= 2004 |pmid= 15322982 |doi= 10.1086/424889
*cite journal | author=Luo W, Marsh-Armstrong N, Rattner A, Nathans J |title=An outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase. |journal=J. Neurosci. |volume=24 |issue= 11 |pages= 2623-32 |year= 2004 |pmid= 15028754 |doi= 10.1523/JNEUROSCI.5302-03.2004
*cite journal | author=Ota T, Suzuki Y, Nishikawa T, "et al." |title=Complete sequencing and characterization of 21,243 full-length human cDNAs. |journal=Nat. Genet. |volume=36 |issue= 1 |pages= 40-5 |year= 2004 |pmid= 14702039 |doi= 10.1038/ng1285
*cite journal | author=Haeseleer F, Jang GF, Imanishi Y, "et al." |title=Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina. |journal=J. Biol. Chem. |volume=277 |issue= 47 |pages= 45537-46 |year= 2003 |pmid= 12226107 |doi= 10.1074/jbc.M208882200
*cite journal | author=Rattner A, Smallwood PM, Nathans J |title=Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol. |journal=J. Biol. Chem. |volume=275 |issue= 15 |pages= 11034-43 |year= 2000 |pmid= 10753906 |doi=
*cite journal | author=Saari JC, Garwin GG, Van Hooser JP, Palczewski K |title=Reduction of all-trans-retinal limits regeneration of visual pigment in mice. |journal=Vision Res. |volume=38 |issue= 10 |pages= 1325-33 |year= 1998 |pmid= 9667000 |doi=

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