NSP2 (rotavirus)

NSP2 (rotavirus)

NSP2, is a rotavirus nonstructural RNA-binding protein that accumulates in cytoplasmic inclusions (viroplasms) and is required for genome replication.[1] NSP2 is closely associated in vivo with the viral replicase.[2] The non-structural protein NSP5 plays a role in the structure of viroplasms mediated by its interaction with NSP2.[3]

References

  1. ^ Kattoura MD, Chen X, Patton JT (August 1994). "The rotavirus RNA-binding protein NS35 (NSP2) forms 10S multimers and interacts with the viral RNA polymerase". Virology 202 (2): 803–813. doi:10.1006/viro.1994.1402. PMID 8030243. 
  2. ^ Aponte C, Poncet D, Cohen J (February 1996). "Recovery and characterization of a replicase complex in rotavirus-infected cells by using a monoclonal antibody against NSP2". Journal of Virology 70 (2): 985–91. PMC 189903. PMID 8551639. http://jvi.asm.org/cgi/pmidlookup?view=long&pmid=8551639. 
  3. ^ Fabbretti E, Afrikanova I, Vascotto F, Burrone OR (February 1999). "Two non-structural rotavirus proteins, NSP2 and NSP5, form viroplasm-like structures in vivo". The Journal of General Virology 80 (2): 333–9. PMID 10073692. http://vir.sgmjournals.org/cgi/pmidlookup?view=long&pmid=10073692. 
v · Viral proteins (early and late)
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capsid: matrix protein (M1 protein) · viral envelope (M2 protein)

glycoprotein: Influenza hemagglutinin · Neuraminidase
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Parainfluenza hemagglutinin-neuraminidase
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Respiratory syncytial virus G protein

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Fusion protein

M: VIR

virs(prot)/clss

cutn/syst (hppv/hiva, infl/zost/zoon)/epon

drugJ(dnaa, rnaa, rtva, vacc)

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