Viroplasm

Viroplasm

A viroplasm is an inclusion body in a cell where viral replication/assembly occurs. They may be thought of as viral factories in the cell. Very little is understood about the mechanism of viroplasm formation. These appear electron-dense under the electron microscope, most likely due to high amounts of viral RNA in them.

Viroplasm where found in the cauliflower mosaic virus cite journal|title=Identification by immunoprecipitation of cauliflower mosaic virus in vitro major translation product with a specific serum against viroplasm protein.|journal=EMBO J|date=1982|first=C|last=Xiong|coauthors=S Muller, G Lebeurier, L Hirth|volume=1|issue=8|pages=971–976|id=16453427|url=http://view.ncbi.nlm.nih.gov/pubmed/16453427|accessdate=2007-11-02] , Rotavirus cite journal|title=Assembly of viroplasm and virus-like particles of rotavirus by a Semliki Forest virus replicon.|journal=Virology|date=1998- Mar- 15|first=M|last=Nilsson|coauthors=C H von Bonsdorff, K Weclewicz, J Cohen, L Svensson|volume=242|issue=2|pages=255–65|id=9514960 doi|10.1006/viro.1997.8987|url=http://view.ncbi.nlm.nih.gov/pubmed/9514960|accessdate=2007-11-02|doi=10.1006/viro.1997.8987] , vaccinia virus cite journal|title=Vaccinia virus A30L protein is required for association of viral membranes with dense viroplasm to form immature virions.|journal=Journal of virology|date=2001- Jul|first=P|last=Szajner|coauthors=A S Weisberg, E J Wolffe, B Moss|volume=75|issue=13|pages=5752–61|id=11390577 doi|10.1128/JVI.75.13.5752-5761.2001|url=http://view.ncbi.nlm.nih.gov/pubmed/11390577|accessdate=2007-11-02|doi=10.1128/JVI.75.13.5752-5761.2001] and Rice dwarf virus (RDV) cite journal|title=Pns4 of rice dwarf virus is a phosphoprotein, is localized around the viroplasm matrix, and forms minitubules.|journal=Archives of virology|date=2006- Sep|first=T|last=Wei|coauthors=A Kikuchi, N Suzuki, T Shimizu, K Hagiwara, H Chen, T Omura|volume=151|issue=9|pages=1701–12|id=16609816 doi|10.1007/s00705-006-0757-4|url=http://view.ncbi.nlm.nih.gov/pubmed/16609816|accessdate=2007-11-02|doi=10.1007/s00705-006-0757-4] /


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  • viroplasm — vi·ro·plasm (viґro plaz″əm) plaques of very fine granular substance that appear in cells before virions are observed and which correspond to the DNA material, as in poxvirus infections …   Medical dictionary

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