NSP5 (rotavirus)

NSP5 (rotavirus)

NSP5 (nonstructural protein 5) encoded by genome segment 11 of group A rotaviruses. In virus-infected cells NSP5 accumulates in the viroplasms. NSP5 has been shown to be autophosphorylated.[1] Interaction of NSP5 with NSP2 was also demonstrated.[2] In rotavirus-infected cells, the non-structural proteins NSP5 and NSP2 localize in complexes called viroplasms, where replication and assembly occur and they can drive the formation of viroplasm-like structures in the absence of other rotaviral proteins and rotavirus replication.[3]

References

  1. ^ Afrikanova I, Miozzo MC, Giambiagi S, Burrone O (September 1996). "Phosphorylation generates different forms of rotavirus NSP5". The Journal of General Virology 77 (9): 2059–65. doi:10.1099/0022-1317-77-9-2059. PMID 8811003. 
  2. ^ Afrikanova I, Fabbretti E, Miozzo MC, Burrone OR (November 1998). "Rotavirus NSP5 phosphorylation is up-regulated by interaction with NSP2". The Journal of General Virology 79 (11): 2679–86. PMID 9820143. http://vir.sgmjournals.org/cgi/pmidlookup?view=long&pmid=9820143. 
  3. ^ Fabbretti E, Afrikanova I, Vascotto F, Burrone OR (February 1999). "Two non-structural rotavirus proteins, NSP2 and NSP5, form viroplasm-like structures in vivo". The Journal of General Virology 80 (2): 333–9. PMID 10073692. http://vir.sgmjournals.org/cgi/pmidlookup?view=long&pmid=10073692. 
v · Viral proteins (early and late)
DNA
HBsAg · HBcAg (HBeAg) · HBx · Hepatitis B virus DNA polymerase
EBNA-1 · EBNA-2 · EBNA-3 · LMP-1 · LMP-2 · EBER
RNA
VNPs: NSP1 · NSP2 · NSP4 · NSP5 · NSP6

capsid: matrix protein (M1 protein) · viral envelope (M2 protein)

glycoprotein: Influenza hemagglutinin · Neuraminidase
Parainfluenza
Parainfluenza hemagglutinin-neuraminidase
RSV
Respiratory syncytial virus G protein

VSPs: E1 · E2

VNPs: P7 · NS2 · NS3 · NS4 · NS5
RT

VSPs: gag · pol (Integrase, Reverse transcriptase, HIV-1 protease) · env (gp120, gp41)

VRAPs: transactivators (Tat, Rev, Vpr) · Nef · Vif · Vpu
Fusion protein

M: VIR

virs(prot)/clss

cutn/syst (hppv/hiva, infl/zost/zoon)/epon

drugJ(dnaa, rnaa, rtva, vacc)



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