NSP5 (rotavirus)

NSP5 (rotavirus)

NSP5 (nonstructural protein 5) encoded by genome segment 11 of group A rotaviruses. In virus-infected cells NSP5 accumulates in the viroplasms. NSP5 has been shown to be autophosphorylated.[1] Interaction of NSP5 with NSP2 was also demonstrated.[2] In rotavirus-infected cells, the non-structural proteins NSP5 and NSP2 localize in complexes called viroplasms, where replication and assembly occur and they can drive the formation of viroplasm-like structures in the absence of other rotaviral proteins and rotavirus replication.[3]

References

  1. ^ Afrikanova I, Miozzo MC, Giambiagi S, Burrone O (September 1996). "Phosphorylation generates different forms of rotavirus NSP5". The Journal of General Virology 77 (9): 2059–65. doi:10.1099/0022-1317-77-9-2059. PMID 8811003. 
  2. ^ Afrikanova I, Fabbretti E, Miozzo MC, Burrone OR (November 1998). "Rotavirus NSP5 phosphorylation is up-regulated by interaction with NSP2". The Journal of General Virology 79 (11): 2679–86. PMID 9820143. http://vir.sgmjournals.org/cgi/pmidlookup?view=long&pmid=9820143. 
  3. ^ Fabbretti E, Afrikanova I, Vascotto F, Burrone OR (February 1999). "Two non-structural rotavirus proteins, NSP2 and NSP5, form viroplasm-like structures in vivo". The Journal of General Virology 80 (2): 333–9. PMID 10073692. http://vir.sgmjournals.org/cgi/pmidlookup?view=long&pmid=10073692. 
v · Viral proteins (early and late)
DNA
HBsAg · HBcAg (HBeAg) · HBx · Hepatitis B virus DNA polymerase
EBNA-1 · EBNA-2 · EBNA-3 · LMP-1 · LMP-2 · EBER
RNA
VNPs: NSP1 · NSP2 · NSP4 · NSP5 · NSP6

capsid: matrix protein (M1 protein) · viral envelope (M2 protein)

glycoprotein: Influenza hemagglutinin · Neuraminidase
Parainfluenza
Parainfluenza hemagglutinin-neuraminidase
RSV
Respiratory syncytial virus G protein

VSPs: E1 · E2

VNPs: P7 · NS2 · NS3 · NS4 · NS5
RT

VSPs: gag · pol (Integrase, Reverse transcriptase, HIV-1 protease) · env (gp120, gp41)

VRAPs: transactivators (Tat, Rev, Vpr) · Nef · Vif · Vpu
Fusion protein

M: VIR

virs(prot)/clss

cutn/syst (hppv/hiva, infl/zost/zoon)/epon

drugJ(dnaa, rnaa, rtva, vacc)



Wikimedia Foundation. 2010.

Игры ⚽ Поможем написать реферат

Look at other dictionaries:

  • Rotavirus — Saltar a navegación, búsqueda ? Rotavirus Una micrografía electrónica de Rotavirus: obsérvese el aspecto de «rueda» del virión …   Wikipedia Español

  • Rotavirus — Taxobox name = Rotavirus status = status ref = image width = 180px image caption = Electron micrograph of Rotaviruses. The bar = 100 nm image2 width = image2 caption = virus group = iii familia = Reoviridae genus = Rotavirus species = A, B, C, D …   Wikipedia

  • NSP2 (rotavirus) — NSP2, is a rotavirus nonstructural RNA binding protein that accumulates in cytoplasmic inclusions (viroplasms) and is required for genome replication.[1] NSP2 is closely associated in vivo with the viral replicase.[2] The non structural protein… …   Wikipedia

  • NSP6 (rotavirus) — Gene 11 of Rotavirus encodes a nonstructural protein, NSP5 and also encodes NSP6, from an out of phase open reading frame.[1] In contrast to the other rotavirus non structural proteins, NSP6 was found to have a high rate of turnover, being… …   Wikipedia

  • NSP1 (rotavirus) — NSP1, the product of rotavirus gene 5, is an nonstructural RNA binding protein that contains a cysteine rich region and is a component of early replication intermediates. RNA folding predictions suggest that this region of the NSP1 mRNA can… …   Wikipedia

  • NSP6 (rotavirus) — El Gen 11 del rotavirus codifica una proteína estructural, NSP5 y también codifica NSP6, de un cabo de la fase de lectura abierta.[1] En contraste con los otros rotavirus con proteínas no estructurales, NSP6 se encontró que tenía un alto índice… …   Wikipedia Español

  • NSP4 (rotavirus) — The rotavirus nonstructural protein NSP4 was the first viral enterotoxin discovered. It induces diarrhea and causes Ca2+ dependent transepithelial secretion.[1] References ^ Dong, Y.; Zeng, CQ; Ball, JM; Estes, MK; Morris, AP (1997). The… …   Wikipedia

  • Viral nonstructural protein — In virology, a nonstructural protein is a protein encoded by a virus but it is not part of the viral particle.[1] See also NSP1 (rotavirus) NSP4 (rotavirus) NSP5 (rotavirus) NSP6 (virus) References ^ MeSH …   Wikipedia

  • Hepatitis B virus — For the disease, see Hepatitis B. Hepatitis B virus TEM micrograph showing hepatitis B viruses Virus classification Group …   Wikipedia

  • Structure and genome of HIV — The genome and proteins of HIV have been the subject of extensive research since the discovery of the virus in 1983.[1][2] The discovery of the virus itself was not until two years after the first major cases of AIDS associated illnesses were… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”