NSP4 (rotavirus)

NSP4 (rotavirus)

The rotavirus nonstructural protein NSP4 was the first viral enterotoxin discovered. It induces diarrhea and causes Ca2+-dependent transepithelial secretion.[1]

References

  1. ^ Dong, Y.; Zeng, CQ; Ball, JM; Estes, MK; Morris, AP (1997). "The rotavirus enterotoxin NSP4 mobilizes intracellular calcium in human intestinal cells by stimulating phospholipase C-mediated inositol 1,4,5-trisphosphate production". Proceedings of the National Academy of Sciences 94 (8): 3960–5. doi:10.1073/pnas.94.8.3960. PMC 20550. PMID 9108087. http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pmcentrez&artid=20550. 
v · Viral proteins (early and late)
DNA
HBsAg · HBcAg (HBeAg) · HBx · Hepatitis B virus DNA polymerase
EBNA-1 · EBNA-2 · EBNA-3 · LMP-1 · LMP-2 · EBER
RNA
VNPs: NSP1 · NSP2 · NSP4 · NSP5 · NSP6

capsid: matrix protein (M1 protein) · viral envelope (M2 protein)

glycoprotein: Influenza hemagglutinin · Neuraminidase
Parainfluenza
Parainfluenza hemagglutinin-neuraminidase
RSV
Respiratory syncytial virus G protein

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RT

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VRAPs: transactivators (Tat, Rev, Vpr) · Nef · Vif · Vpu
Fusion protein

M: VIR

virs(prot)/clss

cutn/syst (hppv/hiva, infl/zost/zoon)/epon

drugJ(dnaa, rnaa, rtva, vacc)

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  • NSP1 (rotavirus) — NSP1, the product of rotavirus gene 5, is an nonstructural RNA binding protein that contains a cysteine rich region and is a component of early replication intermediates. RNA folding predictions suggest that this region of the NSP1 mRNA can… …   Wikipedia

  • NSP5 (rotavirus) — NSP5 (nonstructural protein 5) encoded by genome segment 11 of group A rotaviruses. In virus infected cells NSP5 accumulates in the viroplasms. NSP5 has been shown to be autophosphorylated.[1] Interaction of NSP5 with NSP2 was also… …   Wikipedia

  • NSP2 (rotavirus) — NSP2, is a rotavirus nonstructural RNA binding protein that accumulates in cytoplasmic inclusions (viroplasms) and is required for genome replication.[1] NSP2 is closely associated in vivo with the viral replicase.[2] The non structural protein… …   Wikipedia

  • NSP6 (rotavirus) — Gene 11 of Rotavirus encodes a nonstructural protein, NSP5 and also encodes NSP6, from an out of phase open reading frame.[1] In contrast to the other rotavirus non structural proteins, NSP6 was found to have a high rate of turnover, being… …   Wikipedia

  • Viral nonstructural protein — In virology, a nonstructural protein is a protein encoded by a virus but it is not part of the viral particle.[1] See also NSP1 (rotavirus) NSP4 (rotavirus) NSP5 (rotavirus) NSP6 (virus) References ^ MeSH …   Wikipedia

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