Chronic myelomonocytic leukemia

Chronic myelomonocytic leukemia
Chronic myelomonocytic leukemia
Classification and external resources
ICD-O: M9945/3
MeSH D015477

Chronic myelomonocytic leukemia (CMML) is a form of leukemia featuring monocytosis.[1]

The categorization of this disease has been controversial. Patients with CMML can present with various different clinical features, mimicking either myelodysplastic syndroms or myeloproliferative neoplasms depending upon a patient's specific presentation. Due to this controversy it was classified by the World Health Organization in a "myelodysplastic/myeloproliferative" category of medical conditions in the early 2000s.[2][3]

Some clinicians distinguish between myelodysplastic and myeloproliferative forms of CMML.[4]

See also

References

  1. ^ "Myelodysplastic/Myeloproliferative Diseases Treatment - National Cancer Institute". http://www.cancer.gov/cancertopics/pdq/treatment/mds-mpd/HealthProfessional/page3. 
  2. ^ Cortes J (2003). "CMML: a biologically distinct myeloproliferative disease". Curr. Hematol. Rep. 2 (3): 202–8. PMID 12901341. 
  3. ^ Elliott MA (2006). "Chronic neutrophilic leukemia and chronic myelomonocytic leukemia: WHO defined". Best Pract Res Clin Haematol 19 (3): 571–93. doi:10.1016/j.beha.2005.07.012. PMID 16781489. 
  4. ^ Voglová J, Chrobák L, Neuwirtová R, Malasková V, Straka L (2001). "Myelodysplastic and myeloproliferative type of chronic myelomonocytic leukemia--distinct subgroups or two stages of the same disease?". Leuk. Res. 25 (6): 493–9. doi:10.1016/S0145-2126(00)00159-4. PMID 11337023. http://linkinghub.elsevier.com/retrieve/pii/S0145-2126(00)00159-4. 
CFU-Baso
CFU-Eos
MEP
CFU-Meg
CFU-E
MD (Refractory anemia, Refractory anemia with excess of blasts, Chromosome 5q deletion syndrome, Sideroblastic anemia, Paroxysmal nocturnal hemoglobinuria, Refractory cytopenia with multilineage dysplasia)
CFU-Mast
Mastocytosis: Diffuse cutaneous mastocytosis · Erythrodermic mastocytosis · Generalized eruption of cutaneous mastocytosis (adult type) · Generalized eruption of cutaneous mastocytosis (childhood type) · Mast cell sarcoma · Solitary mastocytoma · Systemic mastocytosis · Xanthelasmoidal mastocytosis
Multiple/unknown

M: MYL

cell/phys (coag, heme, immu, gran), csfs

rbmg/mogr/tumr/hist, sysi/epon, btst

drug (B1/2/3+5+6), btst, trns

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