HLA-DRB1

HLA-DRB1

Major histocompatibility complex, class II, DR beta 1, also known as HLA-DRB1, is a human gene.cite web | title = Entrez Gene: HLA-DRB1 major histocompatibility complex, class II, DR beta 1| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene&Cmd=ShowDetailView&TermToSearch=3123| accessdate = ] DRB1 encodes the the most prevalent beta subunit of HLA-DR.

Function

The protein encoded by this gene belongs to the HLA class II beta chain paralogues. The class II molecule is a heterodimer consisting of an alpha (DRA) and a beta chain (DRB), both anchored in the membrane. It plays a central role in the immune system by presenting peptides derived from extracellular proteins. Class II molecules are expressed in antigen presenting cells (APC: B lymphocytes, dendritic cells, macrophages).

Gene struture and polymorphisms

The beta chain is approximately 26-28 kDa. It is encoded by 6 exons, exon one encodes the leader peptide, exons 2 and 3 encode the two extracellular domains, exon 4 encodes the transmembrane domain and exon 5 encodes the cytoplasmic tail. Within the DR molecule the beta chain contains all the polymorphisms specifying the peptide binding specificities. Hundreds of DRB1 alleles have been described and typing for these polymorphisms is routinely done for bone marrow and kidney transplantation.

Gene expression

DRB1 is expressed at a level five times higher than its paralogues DRB3, DRB4 and DRB5. DRB1 is present in all individuals. Allelic variants of DRB1 are linked with either none or one of the genes DRB3, DRB4 and DRB5. There are 4 related pseudogenes: DRB2, DRB6, DRB7, DRB8 and DRB9.

ee also

* HLA-DR

References

Further reading

PBB_Further_reading
citations =
*cite journal | author=Turesson C, Matteson EL |title=Genetics of rheumatoid arthritis. |journal=Mayo Clin. Proc. |volume=81 |issue= 1 |pages= 94–101 |year= 2006 |pmid= 16438485 |doi=
*cite journal | author=Ahmad T, Marshall SE, Jewell D |title=Genetics of inflammatory bowel disease: the role of the HLA complex. |journal=World J. Gastroenterol. |volume=12 |issue= 23 |pages= 3628–35 |year= 2006 |pmid= 16773677 |doi=
*cite journal | author=Schmidt H, Williamson D, Ashley-Koch A |title=HLA-DR15 haplotype and multiple sclerosis: a HuGE review. |journal=Am. J. Epidemiol. |volume=165 |issue= 10 |pages= 1097–109 |year= 2007 |pmid= 17329717 |doi= 10.1093/aje/kwk118

PBB_Controls
update_page = yes
require_manual_inspection = no
update_protein_box = yes
update_summary = no
update_citations = yes


Wikimedia Foundation. 2010.

Игры ⚽ Поможем сделать НИР

Look at other dictionaries:

  • HLA-DQ8 — (MHC Class II, DQ cell surface antigen) Rendering of HLA DQ8 with immundoinant insulin peptide in the binding pocket. Cis haplotype Haplotype …   Wikipedia

  • HLA-DR52 — is an HLA DR serotype that recognizes gene products of HLA DRB3 locus. There are 3 allele groups that can produce 35 isoforms.DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution.cite… …   Wikipedia

  • HLA-DR53 — is an HLA DR serotype that recognizes gene products of HLA DRB4 locus. There are 13 alleles at this locus that encode 7 proteins.DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution.cite… …   Wikipedia

  • HLA-DR2 — (DR2) of the HLA DR serotype system, is a broad antigen serotype that is now preferentially covered by HLA DR15 and HLA DR16 serotype group. This serotype primarily recognizes gene products of the HLA DRB1*15 and HLA DRB1*16 allele groups.… …   Wikipedia

  • HLA-DR6 — (DR6) is a broad antigen serotype that is further split into HLA DR13 and HLA DR14 antigen serotypes.erologyDR6 serological reactivity is relatively poor compared to other serological tests for DR antigens. Compare to DQ2 or DR7.Disease… …   Wikipedia

  • HLA-DR14 — HLA DR13 is genetically linked to HLA DR52cite journal |author=Song EY, Park H, Roh EY, Park MH |title=HLA DRB1 and DRB3 allele frequencies and haplotypic associations in Koreans |journal=Hum. Immunol. |volume=65 |issue=3 |pages=270–6 |year=2004… …   Wikipedia

  • HLA-DR13 — is genetically linked to DR52cite journal |author=Song EY, Park H, Roh EY, Park MH |title=HLA DRB1 and DRB3 allele frequencies and haplotypic associations in Koreans |journal=Hum. Immunol. |volume=65 |issue=3 |pages=270–6 |year=2004… …   Wikipedia

  • HLA-DR12 — is genetically linked to DR52cite journal |author=Song EY, Park H, Roh EY, Park MH |title=HLA DRB1 and DRB3 allele frequencies and haplotypic associations in Koreans |journal=Hum. Immunol. |volume=65 |issue=3 |pages=270–6 |year=2004… …   Wikipedia

  • HLA A1-B8-DR3-DQ2 — Mgh haplotype = HLA A1 B8 DR3 DQ2 image source = HLA region on chromosome 6 chromosome = 6 location = 6p21.3 variable = alias = Super B8 , AH8.1 , ancestral MHC 8.1 othertype = Serotype loci1name = Class I loci1rows = 3 gene1name = HLA A gene1var …   Wikipedia

  • HLA-DRB5 — Major histocompatibility complex, class II, DR beta 5, also known as HLA DRB5, is a human gene.cite web | title = Entrez Gene: HLA DRB5 major histocompatibility complex, class II, DR beta 5| url = http://www.ncbi.nlm.nih.gov/sites/entrez?Db=gene… …   Wikipedia

Share the article and excerpts

Direct link
… Do a right-click on the link above
and select “Copy Link”