- HLA-DR2
HLA-DR2 (DR2) of the HLA-DR
serotype system, is a broad antigen serotype that is now preferentially covered byHLA-DR15 andHLA-DR16 serotype group. This serotype primarily recognizes gene products of the HLA-DRB1*15 and HLA-DRB1*16 allele groups.=Serology=
=Disease associations=DR2 serotypes are associated with
Goodpasture syndrome ,multiple sclerosis [cite journal | author = Stewart G, McLeod J, Basten A, Bashir H | title = HLA family studies and multiple sclerosis: A common gene, dominantly expressed. | journal = Hum Immunol | volume = 3 | issue = 1 | pages = 13–29 | year = 1981 | pmid = 7275697 | doi = 10.1016/0198-8859(81)90040-9] , andnarcolepsy , tuberculoid leprosy [cite journal | author = van Eden W, de Vries R, Mehra N, Vaidya M, D'Amaro J, van Rood J | title = HLA segregation of tuberculoid leprosy: confirmation of the DR2 marker. | journal = J Infect Dis | volume = 141 | issue = 6 | pages = 693–701 | year = 1980 | pmid = 6156220] (multi-drug resistent tuberculosis or leprosy),cite journal | author = Singh M, Balamurugan A, Katoch K, Sharma SK, Mehra NK | title = Immunogenetics of mycobacterial infections in the North Indian population | journal = Tissue Antigens | volume = 69 Suppl 1 | issue = | pages = 228–30 | year = 2007 | pmid = 17445206 | doi = 10.1111/j.1399-0039.2006.77311.x]Hashimoto's thyroiditis [cite journal | author = Azuma Y, Sakurami T, Ueno Y, Ohishi M, Saji H, Terasaki P, Park M | title = HLA-DR antigens in Japanese with Hashimoto's thyroiditis and Graves' disease. | journal = Endocrinol Jpn | volume = 29 | issue = 4 | pages = 423–7 | year = 1982 | pmid = 6961032] , ulcerative colitis(Japanese) [cite journal | author = Asakura H, Tsuchiya M, Aiso S, Watanabe M, Kobayashi K, Hibi T, Ando K, Takata H, Sekiguchi S | title = Association of the human lymphocyte-DR2 antigen with Japanese ulcerative colitis. | journal = Gastroenterology | volume = 82 | issue = 3 | pages = 413–8 | year = 1982 | pmid = 6947923] ,primary biliary cirrhosis and autoimmune hepatitis [cite journal | author = Miyamori H, Kato Y, Kobayashi K, Hattori N | title = HLA antigens in Japanese patients with primary biliary cirrhosis and autoimmune hepatitis. | journal = Digestion | volume = 26 | issue = 4 | pages = 213–7 | year = 1983 | pmid = 6409699] . DR2 is also found in all patients that test positive for anti-anti-Asn-RNA-synthetaes and chronic interstitial lung disease.cite journal | author = Hirakata M, Suwa A, Takada T, "et al" | title = Clinical and immunogenetic features of patients with autoantibodies to asparaginyl-transfer RNA synthetase | journal = Arthritis Rheum. | volume = 56 | issue = 4 | pages = 1295–303 | year = 2007 | pmid = 17393393 | doi = 10.1002/art.22506]=Genetic linkage=DR2 is linked to the
HLA-DR53 .=References=
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