- HLA-DR51
HLA-DR51 is a
HLA-DR serotype that recognizes the antigens encoded by the minor DR locusHLA-DRB5 .DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution.cite journal |author=Gorski J, Rollini P, Mach B |title=Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic |journal=Immunogenetics |volume=25 |issue=6 |pages=397–402 |year=1987 |pmid=3596674 |doi= |issn=] having diverged from DRB1 approximately 4 million years ago.cite journal | author = Gongora R, Figueroa F, Klein J | title = The HLA-DRB9 gene and the origin of HLA-DR haplotypes | journal = Hum. Immunol. | volume = 51 | issue = 1 | pages = 23–31 | year = 1996 | pmid = 8911994 | doi = ]
DRB5 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.
=Alleles=
DRB5* is subdivided into two allele groups, DRB5*01 and DRB5*02. B5*01 encodes 14 alleles and 11 isoforms. B5*02 encoded 4 alleles that can generate 4 isoforms. Only 3 of these have been surveyed by serotyping. There are numerous null genes at this locus.
DRB5*01 allele group
* 14 Alleles: 11 proteins, 2 Nulls
* DR51 Serotype: *0101, *0102
* Serotype unknown: *0103 to *0107, *0109, *0110 to *0113
* Nulls: *0108N, *0110NDRB5*02 allele group
* 4 Alleles: 4 proteins
* DR51 Serotype: *0202,
* Serotype unknown: *0203 to *0205=Associated diseases=
DR51 serotype is positively associated with The following HLA-DRB5 alleles are associated with disease:
DRB5*0101:DRB1*1501 Multiple sclerosis [cite journal | author = Sospedra M, Muraro P, Stefanová I, Zhao Y, Chung K, Li Y, Giulianotti M, Simon R, Mariuzza R, Pinilla C, Martin R | title = Redundancy in antigen-presenting function of the HLA-DR and -DQ molecules in the multiple sclerosis-associated HLA-DR2 haplotype. | journal = J Immunol | volume = 176 | issue = 3 | pages = 1951–61 | year = 2006 | pmid = 16424227] , leprosy [cite journal | author = Joko S, Numaga J, Kawashima H, Namisato M, Maeda H | title = Human leukocyte antigens in forms of leprosy among Japanese patients. | journal = Int J Lepr Other Mycobact Dis | volume = 68 | issue = 1 | pages = 49–56 | year = 2000 | pmid = 10834069]
DRB1 linkage
HLA-DRB5 (DR51)is linked to the following HLA-DR serotypes and DRB1 allele groups.
HLA-DR2
*HLA-DR15 - DRB1*15
*HLA-DR16 - DRB1*16=References=
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