HLA-DR52

HLA-DR52

HLA-DR52 is an HLA-DR serotype that recognizes gene products of HLA-DRB3 locus. There are 3 allele groups that can produce 35 isoforms.

DRB3, DRB4, and DRB5 are minor DR beta encoding loci, they have been recognized as having distinct evolution.cite journal |author=Gorski J, Rollini P, Mach B |title=Structural comparison of the genes of two HLA-DR supertypic groups: the loci encoding DRw52 and DRw53 are not truly allelic |journal=Immunogenetics |volume=25 |issue=6 |pages=397–402 |year=1987 |pmid=3596674 |doi= |issn=] having diverged from DRB1 approximately 4 million years ago.cite journal | author = Gongora R, Figueroa F, Klein J | title = The HLA-DRB9 gene and the origin of HLA-DR haplotypes | journal = Hum. Immunol. | volume = 51 | issue = 1 | pages = 23–31 | year = 1996 | pmid = 8911994 | doi = ]

DRB3 locus is only apparent in a small subset of DR haplotypes, and most individuals lack DRB3.

=Alleles=

=Associated diseases=

DR52 serotype is positively associated with systemic sclerosis,cite journal | author = Kuwana M, Kaburaki J, Okano Y, Inoko H, Tsuji K | title = The HLA-DR and DQ genes control the autoimmune response to DNA topoisomerase I in systemic sclerosis (scleroderma) | journal = J. Clin. Invest. | volume = 92 | issue = 3 | pages = 1296–301 | year = 1993 | pmid = 7690776 | doi = ] inflammatory myopathies,cite journal | author = Garlepp MJ | title = Immunogenetics of inflammatory myopathies | journal = Baillière's clinical neurology | volume = 2 | issue = 3 | pages = 579–97 | year = 1993 | pmid = 8156144 | doi = ] inclusion body myositis,cite journal | author = Garlepp MJ, Laing B, Zilko PJ, Ollier W, Mastaglia FL | title = HLA associations with inclusion body myositis | journal = Clin. Exp. Immunol. | volume = 98 | issue = 1 | pages = 40–5 | year = 1994 | pmid = 7923882 | doi = ]

DRB3*01 is positively associated with sarcoidosis,cite journal | author = Ishihara M, Ishida T, Mizuki N, Inoko H, Ando H, Ohno S | title = Clinical features of sarcoidosis in relation to HLA distribution and HLA-DRB3 genotyping by PCR-RFLP | journal = The British journal of ophthalmology | volume = 79 | issue = 4 | pages = 322–5 | year = 1995 | pmid = 7742275 | doi = ] Grave's Disease, [cite journal | author = Smikie M, Pascoe R, Barton E, Morgan O, Christian N, Dowe G, Roye-Green K, Bailey V, James O | title = HLA-DRB3*0101 is associated with Graves' disease in Jamaicans. | journal = Clin Endocrinol (Oxf) | volume = 55 | issue = 6 | pages = 805–8 | year = 2001 | pmid = 11895223 | doi = 10.1046/j.1365-2265.2001.01414.x] cite journal | author = Chen Q, Huang W, She J, Baxter F, Volpe R, Maclaren N | title = HLA-DRB1*08, DRB1*03/DRB3*0101, and DRB3*0202 are susceptibility genes for Graves' disease in North American Caucasians, whereas DRB1*07 is protective. | journal = J Clin Endocrinol Metab | volume = 84 | issue = 9 | pages = 3182–6 | year = 1999 | pmid = 10487684 | doi = 10.1210/jc.84.9.3182] pulmonary sarcoidosis, [cite journal | author = Grunewald J, Berlin M, Olerup O, Eklund A | title = Lung T-helper cells expressing T-cell receptor AV2S3 associate with clinical features of pulmonary sarcoidosis. | journal = Am J Respir Crit Care Med | volume = 161 | issue = 3 Pt 1 | pages = 814–8 | year = 2000 | pmid = 10712327]

DRB3*0101:DRB1*0301 is linked to Lofgren's syndrome [cite journal | author = Bogunia-Kubik K, Tomeczko J, Suchnicki K, Lange A | title = HLA-DRB1*03, DRB1*11 or DRB1*12 and their respective DRB3 specificities in clinical variants of sarcoidosis. | journal = Tissue Antigens | volume = 57 | issue = 1 | pages = 87–90 | year = 2001 | pmid = 11169267 | doi = 10.1034/j.1399-0039.2001.057001087.x]

DRB3*0202 is also linked to Grave's disease, serum IgG antibodies to "Chlamydia pneumoniae" with essential hypertension, [cite journal | author = Zabay J, Marco J, Soler J, Contu L, Cappai L, Carcassi C, Gómez G, Mulet J, Munar M, Viader C | title = Association of HLA-DRB3*0202 and serum IgG antibodies to Chlamydia pneumoniae with essential hypertension in a highly homogeneous population from Majorca (Balearic Islands, Spain). | journal = J Hum Hypertens | volume = 19 | issue = 8 | pages = 615–22 | year = 2005 | pmid = 15905891 | doi = 10.1038/sj.jhh.1001872] , acute necrotizing encephalopathy [cite journal | author = Oh H, Kwon S, Kim C, Choe B, Ko C, Jung H, Suh J, Lee J | title = Molecular analysis of HLA class II-associated susceptibility to neuroinflammatory diseases in Korean children. | journal = J Korean Med Sci | volume = 19 | issue = 3 | pages = 426–30 | year = 2004 | pmid = 15201511]

DRB3*0301 is weakly associated with anti-cardiolipin antibodies in SLE [cite journal | author = Galeazzi M, Sebastiani G, Tincani A, et al. | title = HLA class II alleles associations of anticardiolipin and anti-beta2GPI antibodies in a large series of European patients with systemic lupus erythematosus. | journal = Lupus | volume = 9 | issue = 1 | pages = 47–55 | year = 2000 | pmid = 10715100 | doi = 10.1177/096120330000900109]

DRB3*0301:DRB1*1302 may be associated with Crohn's diseaes [cite journal | author = Cariappa A, Sands B, Forcione D, et al. | title = Analysis of MHC class II DP, DQ and DR alleles in Crohn's disease. | journal = Gut | volume = 43 | issue = 2 | pages = 210–5 | year = 1998 | pmid = 10189846]

DRB1 linkage

HLA-DRB3 is linked to the following HLA-DR serotypes and DRB1 allele groups.

HLA-DR3 - DRB1*03

HLA-DR5 -
* HLA-DR11 - DRB1*11
* HLA-DR12 - DRB1*12

HLA-DR6 -
* HLA-DR13 - DRB1*13
* HLA-DR14 - DRB1*14

=References=


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