HLA-DR5

HLA-DR5 (DR5) is a broad-antigen serotype that is further split into HLA-DR11 and HLA-DR12 antigen serotypes.

=Serology=

With the exception of a few DRB1* alleles the reactivity of DR5 is relatively poor.

=Disease associations=DR5 is associated with persistent generalized lymphadenopathy (PGL) [cite journal | author = Raffoux C, David V, Couderc L, Rabian C, Clauvel J, Seligmann M, Colombani J | title = HLA-A, B and DR antigen frequencies in patients with AIDS-related persistent generalized lymphadenopathy (PGL) and thrombocytopenia. | journal = Tissue Antigens | volume = 29 | issue = 1 | pages = 60–2 | year = 1987 | pmid = 3495904] and Kaposi sarcoma in AIDS [cite journal | author = Pollack M, Safai B, Myskowski P, Gold J, Pandey J, Dupont B | title = Frequencies of HLA and Gm immunogenetic markers in Kaposi's sarcoma. | journal = Tissue Antigens | volume = 21 | issue = 1 | pages = 1–8 | year = 1983 | pmid = 6601312] , juvenile rheumatoid arthritis [cite journal | author = Førre O, Dobloug J, Høyeraal H, Thorsby E | title = HLA antigens in juvenile arthritis. Genetic basis for the different subtypes. | journal = Arthritis Rheum | volume = 26 | issue = 1 | pages = 35–8 | year = 1983 | pmid = 6401993] [cite journal | author = Suciu-Foca N, Jacobs J, Godfrey M, Woodward K, Khan R, Reed E, Rohowsky C | title = HLA-DR5 in juvenile rheumatoid arthritis confined to few joints. | journal = Lancet | volume = 2 | issue = 8184 | pages = 40 | year = 1980 | pmid = 6104257] , pernicious anemia, Hashimoto's thyroiditis [cite journal | author = Farid N, Sampson L, Moens H, Barnard J | title = The association of goitrous autoimmune thyroiditis with HLA-DR5. | journal = Tissue Antigens | volume = 17 | issue = 3 | pages = 265–8 | year = 1981 | pmid = 6947505] [cite journal | author = Schleusener H, Schernthaner G, Mayr W, Kotulla P, Bogner U, Finke R, Meinhold H, Koppenhagen K, Wenzel K | title = HLA-DR3 and HLA-DR5 associated thyrotoxicosis--two different types of toxic diffuse goiter. | journal = J Clin Endocrinol Metab | volume = 56 | issue = 4 | pages = 781–5 | year = 1983 | pmid = 6131902] , mycosis fungoides [cite journal | author = Safai B, Myskowski P, Dupont B, Pollack M | title = Association of HLA-DR5 with mycosis fungoides. | journal = J Invest Dermatol | volume = 80 | issue = 5 | pages = 395–7 | year = 1983 | pmid = 6601679 | doi = 10.1111/1523-1747.ep12553615] , polyglandular deficiency syndrome [cite journal | author = Shapiro M, Zamir R, Weiss E, Radnay J, Shenkman L | title = The polyglandular deficiency syndrome: a new variant in Persian Jews. | journal = J Endocrinol Invest | volume = 10 | issue = 1 | pages = 1–7 | year = 1987 | pmid = 3496374] , systemic sclerosis [cite journal | author = Pereira S, Black C, Welsh K, Ansell B, Jayson M, Maddison P, Rowell N | title = Autoantibodies and immunogenetics in 30 patients with systemic sclerosis and their families. | journal = J Rheumatol | volume = 14 | issue = 4 | pages = 760–5 | year = 1987 | pmid = 3499513] [cite journal | author = Luderschmidt C, Scholz S, Mehlhaff E, König G, Albert E | title = Association of progressive systemic scleroderma to several HLA-B and HLA-DR alleles. | journal = Arch Dermatol | volume = 123 | issue = 9 | pages = 1188–91 | year = 1987 | pmid = 3498440 | doi = 10.1001/archderm.123.9.1188] , childhood epilepsy [cite journal | author = Minev M, Martinova F, Belopitova L | title = On the association of the HLA system with epilepsy in children. | journal = Epilepsia | volume = 28 | issue = 1 | pages = 74–6 | year = | pmid = 3098558 | doi = 10.1111/j.1528-1157.1987.tb03626.x] , early-onset alopecia areata [cite journal | author = Orecchia G, Belvedere M, Martinetti M, Capelli E, Rabbiosi G | title = Human leukocyte antigen region involvement in the genetic predisposition to alopecia areata. | journal = Dermatologica | volume = 175 | issue = 1 | pages = 10–4 | year = 1987 | pmid = 3497062] , short-ragweed Ra6 allergy [cite journal | author = Marsh D, Freidhoff L, Ehrlich-Kautzky E, Bias W, Roebber M | title = Immune responsiveness to Ambrosia artemisiifolia (short ragweed) pollen allergen Amb a VI (Ra6) is associated with HLA-DR5 in allergic humans. | journal = Immunogenetics | volume = 26 | issue = 4-5 | pages = 230–6 | year = 1987 | pmid = 3498688 | doi = 10.1007/BF00346517] , primary antiphospholipid syndrome [cite journal | author = Vargas-Alarcon G, Granados J, Bekker C, Alcocer-Varela J, Alarcón-Segovia D | title = Association of HLA-DR5 (possibly DRB1*1201) with the primary antiphospholipid syndrome in Mexican patients. | journal = Arthritis Rheum | volume = 38 | issue = 9 | pages = 1340–1 | year = 1995 | pmid = 7575732 | doi = 10.1002/art.1780380925] , and increased longevity in the Dutch [cite journal | author = Lagaay A, D'Amaro J, Ligthart G, Schreuder G, van Rood J, Hijmans W | title = Longevity and heredity in humans. Association with the human leucocyte antigen phenotype. | journal = Ann N Y Acad Sci | volume = 621 | issue = | pages = 78–89 | year = | pmid = 1859103]

=Genetic linkage=HLA-DR5 reactive gene products are linked to serology of HLA-DRB3 (HLA-DR52).

=References=